The connection between endometriosis and secondary dysmenorrhea

Begum IA; Ismat Ara Begum

doi:10.1016/j.jri.2025.104425

The connection between endometriosis and secondary dysmenorrhea

Begum IA, Ismat Ara Begum

Journal of Reproductive Immunology · 2025 · vol. 168 , pp. 104425 · doi:10.1016/j.jri.2025.104425 · PMID:39823689 · W4406166072

review OA: closed CC0 ⤵ 1 in-corpus citation

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This paper examines the relationship between endometriosis and secondary dysmenorrhea.

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Abstract

Endometriosis (EMS) is a prevalent gynecological condition characterized by the presence of endometrial tissue outside the uterus, often leading to secondary dysmenorrhea (SD), chronic pelvic pain and infertility. This review explores the intricate connection between EMS- associated pain and SD, focusing on the pathophysiological mechanisms underlying dysmenorrhea in EMS. Key contributors to pain include inflammation, aberrant immune responses, neurogenic inflammation, peritoneal irritation, peripheral sensitization, central sensitization and cross-organ sensitization. Understanding the pain pathways in EMS highlights the complexity of symptom manifestation and underscores the necessity for a multidisciplinary approach to management. Clinical manifestations, including chronic pelvic pain, dyspareunia, infertility, gastrointestinal and bladder symptoms, fatigue and malaise, are discussed, emphasizing the diverse impact of EMS on women's health. Various treatment modalities, ranging from pharmacological interventions to surgical and complementary approaches, are outlined to provide comprehensive management strategies for EMS-related menstrual pain/SD. This review aims to enhance understanding and facilitate the effective management of EMS-associated SD, ultimately improving the quality of life for affected individuals.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_pain

MeSH descriptors

Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

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Analysis of the levonorgestrel-releasing intrauterine system in women with endometriosis via openalex
Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review) via openalex
An Overview and Management of Painful Menstrual Disorder (Dysmenorrhea): A Narrative Literature Review via openalex
Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis via openalex
An update for endometriosis management: a position statement via openalex
Aromatase inhibitors in the pharmacotherapy of endometriosis via openalex
A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date via openalex
Autonomic nervous system and inflammation interaction in endometriosis-associated pain via openalex
Bladder endometriosis: a summary of current evidence via openalex
Catamenial pneumothorax recurrence due to endometriosis via openalex
Chronic Pelvic Pain via openalex
Co-expression of activating and inhibitory receptors on peritoneal fluid NK cells in women with endometriosis via openalex
Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis via openalex
Diagnosis and management of endometriosis via openalex
Dysmenorrhea via openalex
Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents via openalex
Dysmenorrhea in adolescents via openalex
Dyspareunia via openalex
Efficacy of Cognitive Behavioral Therapy in treating women with endometriosis and chronic pelvic pain: A randomized trial via openalex
Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis via openalex
Emerging strategies for the treatment of endometriosis via openalex
Emotional dysregulation in women with endometriosis with cyclical and non-cyclical chronic pelvic pain via openalex
Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients via openalex
Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms via openalex
Endometriosis: Evaluation and Treatment via openalex
Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread via openalex
Endometriosis-Related Chronic Pelvic Pain via openalex
Evaluation and Management of Endometriosis in the Adolescent via openalex
Gastrointestinal symptoms among endometriosis patients—A case-cohort study via openalex
GnRH agonists in the treatment of symptomatic endometriosis: a review via openalex
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis via openalex
Holistic Approaches in Endometriosis - as an Effective Method of Supporting Traditional Treatment: A Systematic Search and Narrative Review via openalex
Holistic approaches to living well with endometriosis via openalex
Hormonal contraception in women with endometriosis: a systematic review via openalex
“I just want to stay here and sleep forever”: South African patients’ lived experiences of chronic fatigue in endometriosis via openalex
Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis via openalex
Laparoscopic surgery for endometriosis via openalex
Learning to cope with the reality of endometriosis: A mixed-methods analysis of psychological therapy in women with endometriosis via openalex
Bowel Endometriosis: Current Perspectives on Diagnosis and Treatment via openalex
Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model via openalex
Research on central sensitization of endometriosis-associated pain: a systematic review of the literature via openalex
Mechanisms of peripheral sensitization in endometriosis patients with peritoneal lesions and acyclical pain via openalex
Medical Management of Endometriosis in Patients with Chronic Pelvic Pain via openalex
Mindfulness intervention effect on endometriosis-related pain dimensions and its mediator role on stress and vitality: a path analysis approach via openalex
Neurogenic Inflammation in the Context of Endometriosis—What Do We Know? via openalex
Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex
Neuroproliferative dyspareunia in endometriosis and vestibulodynia via openalex
New concepts on the etiology of endometriosis via openalex
Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex
Nonsurgical mouse model of endometriosis-associated pain that responds to clinically active drugs via openalex
Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents via openalex
Organ cross-sensitization mechanisms in chronic diseases related to the genitourinary tract via openalex
Pain Management for Women with Endometriosis via openalex
Patients’ perspectives of endometriosis-related fatigue: qualitative interviews via openalex
Peripheral and central neuroplasticity in a mouse model of endometriosis via openalex
Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes via openalex
Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes via openalex
Pharmacological Management of Endometriosis-related Pain: The Expert Opinion via openalex
PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis via openalex
Premenstrual spotting of ≥2 days is strongly associated with histologically confirmed endometriosis in women with infertility via openalex
Presence of endometriosis and chronic overlapping pain conditions negatively impacts the pain experience in women with chronic pelvic-abdominal pain: A cross-sectional survey via openalex
Prevalence of symptoms consistent with a diagnosis of vulvodynia: population-based estimates from 2 geographic regions via openalex
Primary Dysmenorrhea: Assessment and Treatment via openalex
Progesterone receptor ligands for the treatment of endometriosis via openalex
Rich innervation of deep infiltrating endometriosis via openalex
Role of neuropeptides in patients with endometriosis: a literature review via openalex
Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis via openalex
Stressful experiences impact clinical symptoms in people with endometriosis via openalex
Surgical Treatment of Endometriosis via openalex
Targeting Oxidative Stress Involved in Endometriosis and Its Pain via openalex
The Association Between Gastrointestinal Symptoms and Transvaginal Ultrasound Findings in Women Referred for Endometriosis Evaluation: A Prospective Pilot Study via openalex
The Burden of Endometriosis on Women’s Lifespan: A Narrative Overview on Quality of Life and Psychosocial Wellbeing via openalex
The clinical anatomy of dyspareunia: A review via openalex
The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis via openalex
The Importance of Diet in the Treatment of Endometriosis via openalex
The influence of endometriosis-related symptoms on work life and work ability: a study of Danish endometriosis patients in employment via openalex
The interplay between systemic inflammatory factors and endometriosis: A bidirectional mendelian randomization study via openalex
The Known, the Unknown and the Future of the Pathophysiology of Endometriosis via openalex
The Main Theories on the Pathogenesis of Endometriosis via openalex
The Menstrual Endometrium: From Physiology to Future Treatments via openalex
The Pathological Role of miRNAs in Endometriosis via openalex
The prevalence of endometriosis in unexplained infertility: a systematic review via openalex
The role of fibrosis in endometriosis: a systematic review via openalex
THE ROLE OF LAPAROSCOPIC SURGERY VS MEDICATION IN IMPROVING FERTILITY IN PATIENTS WITH SUSPECTED ENDOMETRIOSIS via openalex
The Role of NF-κB in Endometrial Diseases in Humans and Animals: A Review via openalex
The role of peripheral nerve signaling in endometriosis via openalex
Update on the management of endometriosis-associated pain in France via openalex
Virtual Mindfulness-Based Therapy for the Management of Endometriosis Chronic Pelvic Pain: A Novel Delivery Platform to Increase Access to Care via openalex
Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives via openalex
Widespread myofascial dysfunction and sensitisation in women with endometriosis‐associated chronic pelvic pain: A cross‐sectional study via openalex
W4353062096 via openalex
W4318392266 via openalex
W4283660296 via openalex
W4280621395 via openalex
W4387955385 via openalex
W4249317513 via openalex
W4224879826 via openalex
W4390570763 via openalex
W4220835311 via openalex

Cited by (1)

Endometriosis-The scapegoat for pelvic pain? 2025

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License: CC0 · commercial use OK

[1] ACOG Committee Opinion No. 760: Dysmenorrhea and Endometriosis in the Adolescent via openalex

[2] Analysis of the levonorgestrel-releasing intrauterine system in women with endometriosis via openalex

[3] Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review) via openalex

[4] An Overview and Management of Painful Menstrual Disorder (Dysmenorrhea): A Narrative Literature Review via openalex

[5] Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis via openalex

[6] An update for endometriosis management: a position statement via openalex

[7] Aromatase inhibitors in the pharmacotherapy of endometriosis via openalex

[8] A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date via openalex

[9] Autonomic nervous system and inflammation interaction in endometriosis-associated pain via openalex

[10] Bladder endometriosis: a summary of current evidence via openalex

[11] Catamenial pneumothorax recurrence due to endometriosis via openalex

[12] Chronic Pelvic Pain via openalex

[13] Co-expression of activating and inhibitory receptors on peritoneal fluid NK cells in women with endometriosis via openalex

[14] Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis via openalex

[15] Diagnosis and management of endometriosis via openalex

[16] Dysmenorrhea via openalex

[17] Dysmenorrhea, Endometriosis and Chronic Pelvic Pain in Adolescents via openalex

[18] Dysmenorrhea in adolescents via openalex

[19] Dyspareunia via openalex

[20] Efficacy of Cognitive Behavioral Therapy in treating women with endometriosis and chronic pelvic pain: A randomized trial via openalex

[21] Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis via openalex

[22] Emerging strategies for the treatment of endometriosis via openalex

[23] Emotional dysregulation in women with endometriosis with cyclical and non-cyclical chronic pelvic pain via openalex

[24] Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients via openalex

[25] Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms via openalex

[26] Endometriosis: Evaluation and Treatment via openalex

[27] Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread via openalex

[28] Endometriosis-Related Chronic Pelvic Pain via openalex

[29] Evaluation and Management of Endometriosis in the Adolescent via openalex

[30] Gastrointestinal symptoms among endometriosis patients—A case-cohort study via openalex

[31] GnRH agonists in the treatment of symptomatic endometriosis: a review via openalex

[32] Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis via openalex

[33] Holistic Approaches in Endometriosis - as an Effective Method of Supporting Traditional Treatment: A Systematic Search and Narrative Review via openalex

[34] Holistic approaches to living well with endometriosis via openalex

[35] Hormonal contraception in women with endometriosis: a systematic review via openalex

[36] “I just want to stay here and sleep forever”: South African patients’ lived experiences of chronic fatigue in endometriosis via openalex

[37] Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis via openalex

[38] Laparoscopic surgery for endometriosis via openalex

[39] Learning to cope with the reality of endometriosis: A mixed-methods analysis of psychological therapy in women with endometriosis via openalex

[40] <p>Bowel Endometriosis: Current Perspectives on Diagnosis and Treatment</p> via openalex

[41] <p>Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model</p> via openalex

[42] <p>Research on central sensitization of endometriosis-associated pain: a systematic review of the literature</p> via openalex

[43] Mechanisms of peripheral sensitization in endometriosis patients with peritoneal lesions and acyclical pain via openalex

[44] Medical Management of Endometriosis in Patients with Chronic Pelvic Pain via openalex

[45] Mindfulness intervention effect on endometriosis-related pain dimensions and its mediator role on stress and vitality: a path analysis approach via openalex

[46] Neurogenic Inflammation in the Context of Endometriosis—What Do We Know? via openalex

[47] Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex

[48] Neuroproliferative dyspareunia in endometriosis and vestibulodynia via openalex

[49] New concepts on the etiology of endometriosis via openalex

[50] Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis via openalex

[51] Nonsurgical mouse model of endometriosis-associated pain that responds to clinically active drugs via openalex

[52] Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents via openalex

[53] Organ cross-sensitization mechanisms in chronic diseases related to the genitourinary tract via openalex

[54] Pain Management for Women with Endometriosis via openalex

[55] Patients’ perspectives of endometriosis-related fatigue: qualitative interviews via openalex

[56] Peripheral and central neuroplasticity in a mouse model of endometriosis via openalex

[57] Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes via openalex

[58] Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes via openalex

[59] Pharmacological Management of Endometriosis-related Pain: The Expert Opinion via openalex

[60] PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis via openalex

[61] Premenstrual spotting of ≥2 days is strongly associated with histologically confirmed endometriosis in women with infertility via openalex

[62] Presence of endometriosis and chronic overlapping pain conditions negatively impacts the pain experience in women with chronic pelvic-abdominal pain: A cross-sectional survey via openalex

[63] Prevalence of symptoms consistent with a diagnosis of vulvodynia: population-based estimates from 2 geographic regions via openalex

[64] Primary Dysmenorrhea: Assessment and Treatment via openalex

[65] Progesterone receptor ligands for the treatment of endometriosis via openalex

[66] Rich innervation of deep infiltrating endometriosis via openalex

[67] Role of neuropeptides in patients with endometriosis: a literature review via openalex

[68] Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis via openalex

[69] Stressful experiences impact clinical symptoms in people with endometriosis via openalex

[70] Surgical Treatment of Endometriosis via openalex

[71] Targeting Oxidative Stress Involved in Endometriosis and Its Pain via openalex

[72] The Association Between Gastrointestinal Symptoms and Transvaginal Ultrasound Findings in Women Referred for Endometriosis Evaluation: A Prospective Pilot Study via openalex

[73] The Burden of Endometriosis on Women’s Lifespan: A Narrative Overview on Quality of Life and Psychosocial Wellbeing via openalex

[74] The clinical anatomy of dyspareunia: A review via openalex

[75] The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis via openalex

[76] The Importance of Diet in the Treatment of Endometriosis via openalex

[77] The influence of endometriosis-related symptoms on work life and work ability: a study of Danish endometriosis patients in employment via openalex

[78] The interplay between systemic inflammatory factors and endometriosis: A bidirectional mendelian randomization study via openalex

[79] The Known, the Unknown and the Future of the Pathophysiology of Endometriosis via openalex

[80] The Main Theories on the Pathogenesis of Endometriosis via openalex

[81] The Menstrual Endometrium: From Physiology to Future Treatments via openalex

[82] The Pathological Role of miRNAs in Endometriosis via openalex

[83] The prevalence of endometriosis in unexplained infertility: a systematic review via openalex

[84] The role of fibrosis in endometriosis: a systematic review via openalex

[85] THE ROLE OF LAPAROSCOPIC SURGERY VS MEDICATION IN IMPROVING FERTILITY IN PATIENTS WITH SUSPECTED ENDOMETRIOSIS via openalex

[86] The Role of NF-κB in Endometrial Diseases in Humans and Animals: A Review via openalex

[87] The role of peripheral nerve signaling in endometriosis via openalex

[88] Update on the management of endometriosis-associated pain in France via openalex

[89] Virtual Mindfulness-Based Therapy for the Management of Endometriosis Chronic Pelvic Pain: A Novel Delivery Platform to Increase Access to Care via openalex

[90] Vitamin D, reproductive disorders and assisted reproduction: evidences and perspectives via openalex

[91] Widespread myofascial dysfunction and sensitisation in women with endometriosis‐associated chronic pelvic pain: A cross‐sectional study via openalex

[92] W4353062096 via openalex

[93] W4318392266 via openalex

[94] W4283660296 via openalex

[95] W4280621395 via openalex

[96] W4387955385 via openalex

[97] W4249317513 via openalex

[98] W4224879826 via openalex

[99] W4390570763 via openalex

[100] W4220835311 via openalex