Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis.

Hai Zhu, Yi Wang, Yibo He, Weifeng Yu
American journal of translational research · 2022 · vol. 14(5) , pp. 3066–3078 · PMID:35702089 · W4285740367
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Macrophage polarization and increased TRPV1/TRPA1 heteromers were observed in endometriosis tissues, and inflammation-induced polarization in mice promoted ectopic endometrial cell migration and heteromer formation.

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Abstract

. Macrophage polarization and TRPV1/TRPA1 heteromers in endometriosis tissue of patients were assayed, and was further investigated in endometriosis mice by co-culturing macrophages derived from mice in different groups with human endometrium cells. Our results indicated that macrophage polarization, as CD86 and CD206 positive macrophages, were accompanied by TRPV1/TRPA1 heteromers in endometriosis tissues of patients with pain. Inflammatory factors in peritoneal lavage fluid and serum of mice were correlated with TRPV1/TRPA1 expression in endometriosis tissues of mice as well as macrophage polarization which tended to be consistent with TRPV1/TRPA1 heteromers in endometriosis tissue. Moreover, macrophage polarization in enterocoelia induced ectopic endometrial cells migration with the increase in TRPV1/TRPA1 heteromers. Our results suggest that endometriosis-induced celiac inflammation might mediate macrophage polarization along with the increase of TRPV1/TRPA1 heteromers, which may play a key role in endometriosis pain.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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