Use of Cannabis for Self-Management of Chronic Pelvic Pain
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This survey found that 23% of women with chronic pelvic pain regularly use cannabis for symptom management, with most reporting improvement despite common side effects.
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Abstract
Background: Chronic pelvic pain (CPP) affects up to 15% of women in the United States. The endocannabinoid system is a potential pharmacological target for pelvic pain as cannabinoid receptors are highly expressed in the uterus and other nonreproductive tissues. We hypothesize that cannabis use is common for self-management of CPP, and our primary objective was to determine the prevalence of cannabis use in this population. Materials and Methods: A cross-sectional survey of women with pelvic and perineal pain, dyspareunia, or endometriosis was performed between March and August 2019. Subjects were recruited in an outpatient gynecology office. An anonymous, confidential, electronic survey was performed using a tablet. Statistical analysis was performed using JMP (SAS, Cary, NC). Results: A total of 240 patients were approached, with 113 responses (47.1% response rate). There were 26 patients who used cannabis (23%). The majority used at least once per week (n = 18, 72%). Most users (n = 24, 96%) reported improvement in symptoms, including pain, cramping, muscle spasms, anxiety, depression, sleep disturbances, libido, and irritability. Over one-third (35%) stated that cannabis use decreased the number of phone calls or messages sent to their provider, and 39% reported decreased number of clinical visits. Side effects, including dry mouth, sleepiness, and feeling “high,” were reported by 84% (n = 21). Conclusions: Almost one-quarter of patients with CPP report regular use of cannabis as an adjunct to their prescribed therapy. Although side effects are common, most users report improvement in symptoms. Our study highlights the potential of cannabis as a therapeutic option for patients with CPP.
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Cited by (20)
- Project Twenty21 Australia: A Case Study of the Treatment of Chronic Pelvic Pain Due To Endometriosis with Cannabidiol Oil 2025
- Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis 2025
- Health-related decision-making experiences of people with endometriosis: a qualitative analysis 2025
- Investigational drugs for the treatment of dysmenorrhea 2024
- Holistic approaches to living well with endometriosis 2024
- Perceived challenges in treatment decision-making for endometriosis: healthcare professional perspectives 2024
- Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain among Women with Endometriosis 2024
- Holistic approaches to living well with endometriosis 2024
- Natural compounds for endometriosis and related chronic pelvic pain: A review 2024
- Evaluating the Current Evidence for the Efficacy of Cannabis in Symptom Management of Endometriosis-Associated Pain 2024
- The Place of Cannabinoids in the Treatment of Gynecological Pain 2023
- Therapeutic use of cannabidiol in endometriosis: literature review 2023
- Evaluation and Medical Management of Chronic Pelvic Pain 2023
- Identifying Required Data Elements for Designing A Mobile-Based Application for Self-Care of Women Living with Endometriosis 2023
- Making a joint decision: Cannabis as a potential substitute for opioids in obstetrics and gynecology 2022
- Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis 2022
- Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications 2022
- Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis 2022
- Nonsurgical management of adenomyosis: an overview of current evidence 2022
- Cannabidiol for the Management of Endometriosis and Chronic Pelvic Pain 2021
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- europepmc
- last seen: 2026-08-26T06:08:41.316361+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:21:30.380497+00:00
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