Project Twenty21 Australia: A Case Study of the Treatment of Chronic Pelvic Pain Due To Endometriosis with Cannabidiol Oil

In: Journal of Medical Clinical Case Reports · 2025 · doi:10.47485/2767-5416.1119 · W4412360999
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This case study followed a participant in Project Twenty21 Australia who experienced significant improvement in chronic pelvic pain due to endometriosis after three months of treatment with low-THC CBD oil, along with alleviation of depression and insomnia.

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Abstract

Project Twenty21 Australia was an open label, prospective observational cohort study investigating the effectiveness of medicinal cannabis in alleviating chronic pain, anxiety, PTSD and multiple sclerosis. Participants completed validated questionnaires at baseline then three-monthly (up to 12 months) to assess pain, sleep, mood, quality of life and perceived impression of change. This case study describes a 23-year-old woman who was a participant in Project Twenty21 Australia who presented with chronic pelvic pain due to endometriosis, with comorbidities of anxiety, depression and insomnia. She was prescribed a full spectrum cannabidiol (CBD) oil with a very low amount of tetrahydrocannabinol (THC). At three months follow-up, her pelvic pain had substantially improved. CBD was also able to alleviate some of her other comorbidities including poor sleep and depression and was not associated with any adverse effects. CBD oil, with low THC, may represent a therapeutic option for women with chronic pelvic pain associated with endometriosis, where other therapies have failed.

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Condition tags

endometriosischronic_pelvic_pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (67)

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