American journal of translational research

OBJECTIVE: The analgesic efficacy and safety of transversus abdominis plane block (TAPB) and thoracic paravertebral block (TPVB) were compared following laparoscopic total hysterectomy (LTH), and whether their treatment effects differ by fr…

BACKGROUND: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic, autoimmune inflammatory diseases. Although overlapping clinical and genetic features have been reported, the presence of a direct causal relationship…

OBJECTIVE: To investigate the clinical significance of miR-30d-5p and transforming growth factor-β (TGF-β)/Smad2 pathway expression levels in polycystic ovary syndrome (PCOS) patients. METHODS: A total of 82 PCOS patients undergoing their …

OBJECTIVE: To investigate the efficacy of goserelin (GOS) combined with laparoscopic surgery (LS) in the treatment of endometriosis (EMS), and its effects on ovarian function and oxidative stress (OS). METHODS: A total of 208 patients with…

OBJECTIVE: To identify risk factors for recurrence after hysteroscopic endometrial polypectomy, with particular emphasis on postoperative pathological features (endometrial hyperplastic changes) and potential protective role of medical ther…

OBJECTIVES: The expression of GSDMD and GSDME in ovarian cancerous tissues, adjacent tissues, and cancer cell lines remain poorly characterized. The contribution of pyroptosis to the synergistic therapeutic effects of PI3K-AKT-mTOR inhibito…

OBJECTIVES: Adenomyosis severely impairs fertility and quality of life. This study investigated the pathophysiologic role of cell division cycle 42 (CDC42) in adenomyosis by profiling its expression, identifying its binding partners, and pe…

OBJECTIVE: By using the propensity score matching (PSM) method, this study compared the pregnancy outcomes of two ovulation induction regimens, clomiphene citrate (CC) and letrozole (LE), in intrauterine insemination (IUI) cycles. It aimed …

OBJECTIVE: To evaluate the predictive value of deep myometrial invasion (DMI) for lymph node metastasis (LNM) in low-grade endometrioid carcinoma (LGEC) and its implications for surgical decision-making. METHODS: A retrospective cohort stu…

Endometriosis (EMS) is an estrogen-dependent chronic gynecologic condition that affects approximately 10%-15% of women of childbearing age. Long non-coding RNA SRA (lncRNA SRA) was the first identified non-coding RNA that possesses dual fun…

OBJECTIVE: The aim of this study is to explore the relationship between the levels of anti-Müllerian hormone (AMH) and metabolic and reproductive outcomes across different polycystic ovary syndrome (PCOS) phenotypes. METHODS: In this retro…

OBJECTIVE: This work aimed to evaluate the clinical value of serumanti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and transvaginal ultrasound (TVU) parameters in the diagnosis of ovarian reserve f…

Traditional view holds that the uterus is a sterile environment. However, with the increased development of molecular biology technologies, this classical theory has been re-examined. Increasing evidence shows that a low-biomass, uniquely s…

OBJECTIVE: To systematically evaluate the effects of acupuncture and moxibustion on pain relief, inflammatory biomarkers, and reproductive outcomes in patients with chronic pelvic inflammatory disease (CPID). METHOD: A systematic search wa…

OBJECTIVE: To assess the efficacy of Cai's Gynecology Chronic Pelvic Formula combined with acupuncture in managing chronic pelvic pain (CPP) secondary to pelvic inflammatory disease (PID) sequelae, and its effect on recurrence. METHODS: A …

OBJECTIVE: While physical activity (PA) patterns are epidemiologically linked to gynecologic pathologies, establishing causality remains uncertain. This Mendelian randomization (MR) study evaluated causal relationships between PA phenotypes…

BACKGROUND: Uterine fibroids present significant obstetric challenges, particularly in late pregnancy. This study compared the outcomes of cesarean section combined with myomectomy (CS+M) versus cesarean section followed by elective myomect…

OBJECTIVE: To investigate the correlation between preoperative pathologic characteristics and the risk of postoperative recurrence in endometriosis (EMs) patients, and to develop a clinical predictive model. METHODS: A retrospective analys…

OBJECTIVE: To explore the regulatory function and mechanism of CXCL14 in endometriosis. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine the expression of CXCL14 in eutopic and ectopic endometrial str…

OBJECTIVE: To evaluate the combined effects of Leuprorelin and Mirena on endocrine profiles, emotional well-being, quality of life, and endometrial receptivity (ER) in patients with adenomyosis. METHODS: This is a retrospective cohort stud…

OBJECTIVE: To explore the single and combined therapeutic effects of warm silver needle acupuncture and myofascial trigger point (MTrP) intervention on chronic pelvic pain (CPP). METHODS: CPP patients underwent treatment with warm silver n…

OBJECTIVE: To systematically evaluate the efficacy and safety of Chinese herbal medicine (CHM) for endometriosis-associated pain (EAP). METHODS: Randomized controlled trials (RCTs) were retrieved from PubMed, Embase, and Cochrane Library u…

OBJECTIVE: To evaluate the efficacy of transvaginal erbium laser therapy in the treatment of Vaginal Relaxation Syndrome (VRS) and its effects on key indicators of vaginal health. METHODS: This retrospective study analyzed clinical data fr…

OBJECTIVES: This study aimed to evaluate the effectiveness and feasibility of electroacupuncture (EA) in improving gastrointestinal peristalsis after laparoscopic surgery. METHODS: This was a single-center, two-arm, prospective randomized …

OBJECTIVES: To evaluate the impact of autologous platelet-rich plasma (PRP) intrauterine perfusion on endometrial receptivity and pregnancy outcomes in patients with implantation failure. METHODS: This retrospective cohort study included p…