Endometriosis and gestational diabetes mellitus risk: a systematic review and meta-analysis

Faustino R Pérez-López, Pérez-López FR, Faustino R. Pérez‐López, Martínez-Domínguez SJ, Samuel J. Martínez‐Domínguez, Samuel J Martínez-Domínguez, Andrea Viñas, Viñas A, Raquel Pérez-Tambo, Pérez-Tambo R, Lafita A, Alberto Lafita-López, Alberto Lafita, Héctor Lajusticia, Peter Chedraui, Chedraui P, Health Outcomes and Systematic Analyses (HOUSSAY) Project, for the Health Outcomes and Systematic Analyses (HOUSSAY) Project
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 34(5) , pp. 363–369 · doi:10.1080/09513590.2017.1397115 · PMID:29105527 · W2767883560
review OA: green CC0 ⤵ 18 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This systematic review and meta-analysis of 12 studies found no significant association between endometriosis and the risk of gestational diabetes mellitus.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective: To perform a systematic review and meta-analysis regarding endometriosis and the risk of gestational diabetes mellitus (GDM).Methods: We carried out a search of the following databases: Medline, Embase, Web of Science, Cochrane Library, Scopus, Scielo, Clinicaltrials.gov, the UK Clinical Trials Gateway, and the Australian New Zealand Clinical Trials Registry, from inception through April 28 2017, without language restrictions, in order to evaluate the effect of endometriosis over GDM risk, in women with and without endometriosis. Odds ratios (ORs) and their 95% confidence intervals (CIs) or mean differences (MDs) were calculated as effects. Methodological quality of evidence was assessed with the Newcastle–Ottawa Scale, and heterogeneity among studies with the I2 statistic. Random-effects models were used for meta-analyses, and publication bias was assessed with Egger’s test.Results: We identified 12 studies (10 cohort and two case control studies) with a total of 48,762 pregnancies, including 3,461 with endometriosis. Endometriosis had no significant effect on GDM risk (OR =1.14; 95% CI: 0.86, 1.51; p = .35, I2 = 56%, Egger’s test p = .45). Secondary outcomes (gestational age at delivery, birthweight, and Neonatal Intensive Care Unit admission) were statistically similar in women with and without endometriosis.Conclusions: Better-designed studies are needed to confirm our results.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Diabetes, Gestational Endometriosis Diabetes, Gestational Endometriosis Female Humans Pregnancy Risk

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (18)

Source provenance

europepmc
last seen: 2026-10-07T06:10:45.703000+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:07.505861+00:00
License: CC0 · commercial use OK