Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility

Anne Katerine Omland, Anne K Omland, Thomas Åbyholm, Thomas Abyholm, Peter Fedorcsák, Péter Fedorcsák, Gudvor Ertzeid, Nan Birgitte Oldereid, Nan B Oldereid, Sverre Bjercke, Tom Tanbo
Human Reproduction · 2005 · vol. 20(3) , pp. 722–727 · doi:10.1093/humrep/deh664 · PMID:15591078 · W2095796001
article OA: bronze CC0 ⤵ 63 in-corpus citations
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Pregnancy outcomes including live birth and abortion rates were superior for unexplained infertility compared to endometriosis-associated and tubal factor infertility after IVF/ICSI.

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Abstract

BACKGROUND: This study was undertaken in order to compare pregnancy outcome after IVF and ICSI in unexplained and endometriosis-associated infertility using tubal factor infertility as controls. METHODS: This was a retrospective cohort study of early IVF/ICSI pregnancies verified by serum hCG measurement, comparing the subsequent outcome in unexplained (n = 274) and minimal endometriosis-associated (n = 212) with tubal factor (n = 540) infertility as controls. From January 1990 to December 2002, 1026 conception cycles after treatment with IVF or ICSI complied with the inclusion criteria. RESULTS: Live birth rate, twin birth rate after transfer of two embryos and abortion rate prior to 6 weeks of gestation were superior for the unexplained (78.8, 23.5 and 11.7%) compared to endometriosis-associated (66.0, 15.0 and 19.3%) and tubal factor (66.7, 18.1 and 18.0%) infertility groups (P < 0.05). Compared to the endometriosis-associated, the unexplained infertility group attained a higher pregnancy rate after the first treatment cycle (P < 0.05). CONCLUSIONS: The overall better outcome for the unexplained infertility group with respect to live birth rate, twin birth rate and early abortion rate compared to the minimal peritoneal endometriosis-associated and tubal factor infertility groups might be a guide to select diagnostic groups for single embryo transfer and be useful in patient counselling.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Fallopian Tube Diseases Fertilization in Vitro Infertility, Female Pregnancy Outcome Sperm Injections, Intracytoplasmic Abortion, Spontaneous Abortion, Spontaneous Adult Birth Rate Cohort Studies Endometriosis Fallopian Tube Diseases Female Humans Incidence Infertility, Female Pregnancy Retrospective Studies Twins

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