Research Progress on the Mechanism of Tra-ditional Chinese Medicine in Treating Infer-tility Associated with Endometriosis

In: Traditional Chinese Medicine · 2023 · vol. 12(08) , pp. 2149–2154 · doi:10.12677/tcm.2023.128321 · W4415980730
OA: closed CC0 ⤵ 1 in-corpus citation
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-07-18 ⓘ

This paper reviews research progress on the mechanisms by which traditional Chinese medicine treats infertility associated with endometriosis, highlighting its unique advantages.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-27 · read from full text ⓘ

This review article examines the mechanisms by which traditional Chinese medicine treats infertility associated with endometriosis, noting that half of all endometriosis patients experience this condition. The authors synthesize existing literature to highlight how herbal formulations and acupuncture address multiple pathological targets, including immune inflammation, oxidative stress, and vascularization, while offering a safe profile with minimal side effects. The paper details specific clinical observations and experimental studies demonstrating improvements in oocyte quality, endometrial receptivity, and hormonal balance following treatment. This paper is centrally about endometriosis — specifically focusing on the use of traditional Chinese medicine to manage infertility resulting from the disease.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 6,338 characters · extracted from oa-doi-fallback · click to expand
中药治疗子宫内膜异位症性不孕的研究进展 Research Progress on the Mechanism of Tra-ditional Chinese Medicine in Treating Infer-tility Associated with Endometriosis Research Progress on the Mechanism of Tra-ditional Chinese Medicine in Treating Infer-tility Associated with Endometriosis DOI: 10.12677/TCM.2023.128321, PDF, 被引量 科研立项经费支持 作者: 侯梦卉, 马 静*, 李 莹:天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 关键词: 子宫内膜异位症;不孕;中药;Endometriosis; Infertility; Traditional Chinese Medicine 作者: 侯梦卉, 马 静*, 李 莹:天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 关键词: 子宫内膜异位症;不孕;中药;Endometriosis; Infertility; Traditional Chinese Medicine 摘要: 不孕是子宫内膜异位症最重要的不良影响之一,50%的子宫内膜异位症患者会经历不孕,40%~50%的不孕女性患有子宫内膜异位症。中药以其多途径多靶点,安全无副作用的特点,在治疗子宫内膜异位症中发挥独特优势。本文旨在对中药治疗子宫内膜异位症性不孕的研究进展进行综述,以期为今后的临床研究提供更多参考。 Abstract: Infertility is one of the most important adverse effects of endometriosis. 50% of patients with en-dometriosis will experience infertility, and 40~50% of infertile women will have endometriosis. Traditional Chinese medicine plays a unique role in the treatment of endometriosis with its charac-teristics of multiple approaches, multiple targets, safety and no side effects. The purpose of this ar-ticle is to review the research progress of TCM in the treatment of endometriosis infertility and pro-vide reference for future research. 文章引用:侯梦卉, 马静, 李莹. 中药治疗子宫内膜异位症性不孕的研究进展[J]. 中医学, 2023, 12(8): 2149-2154. https://doi.org/10.12677/TCM.2023.128321 | [1] | 杜娟, 林丽娜, 丛慧芳. 子宫内膜异位症性不孕中医病机治法探析[J]. 长春中医药大学学报, 2021, 37(5): 960-963. | | [2] | Terzic, M., Aimagambetova, G., Kunz, J., Bapayeva, G., Aitbayeva, B., Terzic, S. and Laganà, A.S. (2021) Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives. Interna-tional Journal of Molecular Sciences, 22, Article 9274. [Google Scholar] [CrossRef] [PubMed] | | [3] | de Ziegler, D., Pirtea, P., Carbonnel, M., et al. (2019) Assisted Reproduction in Endometriosis. Best Practice & Research Clinical En-docrinology & Metabolism, 33, 47-59. [Google Scholar] [CrossRef] [PubMed] | | [4] | Evans, M.B. and Decher-ney, A.H. (2017) Fertility and Endometriosis. Clinical Obstetrics and Gynecology, 60, 497-502. [Google Scholar] [CrossRef] | | [5] | Filip, L., Duică, F., Prădatu, A., et al. (2020) Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina, 56, Article 460. [Google Scholar] [CrossRef] [PubMed] | | [6] | Chen, M., He, Y., Zhang, P., et al. (2016) Comparison of Uterine Receptivity between Fertile and Unexplained Infertile Women by Assessment of Endometrial and Subendome-trial Perfusion Using Contrast-Enhanced Ultrasound: Which Index Is Better—Peak Intensity or Area under the Curve? Ultrasound in Medicine and Biology, 42, 654-663. [Google Scholar] [CrossRef] [PubMed] | | [7] | Tomassetti, C., Meuleman, C., Pexsters, A., et al. (2006) Endometriosis, Recurrent Miscarriage and Implantation Failure: Is There an Immunological Link? Reproductive BioMedi-cine Online, 13, 58-64. [Google Scholar] [CrossRef] | | [8] | Omland, A.K., Abyholm, T., Fedorcsák, P., et al. (2005) Pregnancy Outcome after IVF and ICSI in Unexplained, Endometriosis-Associated and Tubal Factor Infertility. Human Reproduction, 20, 722-727. [Google Scholar] [CrossRef] [PubMed] | | [9] | Broi, M., Ferriani, R.A. and Navarro, P.A. (2019) Ethiopathogenic Mechanisms of Endometriosis-Related Infertility. JBRA Assisted Reproduction, 23, 273-280. [Google Scholar] [CrossRef] [PubMed] | | [10] | 宋景艳, 孙振高, 张兴兴, 等. 基于卵母细胞质量探讨子宫内膜异位症导致不孕的机制[J]. 中国性科学, 2018, 27(2): 115-117. | | [11] | 李妞妞, 郭广玲, 王铁延. 子宫内膜异位症与免疫炎症、氧化应激及血管生成的相关性研究[J]. 标记免疫分析与临床, 2018, 25(4): 468-471. | | [12] | 黄飞翔, 丁渊, 应菊娅. 补肾化瘀汤灌肠治疗卵巢型子宫内膜异位症的临床观察[J]. 上海中医药杂志, 2019, 53(12): 52-55. | | [13] | 陈霞, 邬素珍. 邬素珍教授治疗子宫内膜异位症经验总结[J]. 四川中医, 2019, 37(7): 3-5. | | [14] | 叶丽妮, 邝梓君, 王宣尹, 等. 罗氏内异方治疗子宫内膜异位症的研究进展[J]. 广州中医药大学学报, 2021, 38(5): 1067-1071. | | [15] | 王瑞霞, 俞超芹, 俞瑾, 等. 内异方对子宫内膜异位症生殖内分泌调节的实验研究[J]. 南京中医药大学学报, 2005, 21(4): 231-233. | | [16] | 李燕芳. 益肾活血汤加减治疗对子宫内膜异位症合并不孕症患者临床疗效的影响[J]. 实用妇科内分泌电子杂志, 2019, 6(33): 35, 37. | | [17] | 周炳秀, 孙亚男, 刘引串, 等. 桂枝茯苓胶囊对轻型子宫内膜异位不孕症患者血瘀症状、体征及血液流变学的影响[J]. 中医临床研究, 2019, 11(10): 71-73. | | [18] | 孙博, 赵春波, 邵含, 等. 痛愈舒颗粒治疗子宫内膜异位症性不孕[J]. 长春中医药大学学报, 2017, 33(1): 105-108. | | [19] | 林晶, 赵珊琼. 滋肾凉血调周法对子宫内膜异位症合并不孕腹腔镜术后患者TNF-α、IL-8水平影响的临床研究[J]. 中国现代医生, 2017, 55(5): 105-107, 111. | | [20] | 姜晶, 杜菲菲, 王佳楣, 等. 五子四物加减方治疗肾虚血瘀型子宫内膜异位症致不孕症的效果及对子宫内膜容受性影响[J]. 四川中医, 2021, 39(10): 161-164. | | [21] | 具春花, 陈玲. 补肾活血方对内异症伴不孕患者子宫内膜的影响[J]. 辽宁中医杂志, 2008, 35(5): 722-723. | | [22] | 姜华颖. 基于准靶向代谢组学探讨补肾祛瘀中药对子宫内膜异位症相关不孕症的作用机制[D]: [硕士学位论文]. 济南: 山东中医药大学, 2019. | | [23] | 刘艳巧, 刘润侠. 中药内异消对大鼠子宫内膜异位症血管生成因子的影响[J]. 西安交通大学学报(医学版), 2003, 24(5): 502-504. | | [24] | 李安吉. 子宫内膜异位症相关性不孕症卵母细胞质量受损机制及内异方干预作用研究[D]: [博士学位论文]. 上海: 上海中医药大学, 2019. | | [25] | 钟高堂. 补肾活血汤在多囊卵巢综合征促排卵中的疗效[J]. 医学综述, 2012, 18(2): 306-307. | | [26] | 陈丹. 中医综合治疗子宫内膜异位症不孕的临床研究[J]. 中医临床研究, 2014(14): 64-65. | | [27] | 邱海明. 温经化癥汤治疗寒凝血瘀型子宫内膜异位症所致不孕症的临床研究[D]: [硕士学位论文]. 济南: 山东中医药大学, 2018. | | [28] | 刘新军, 张振卿, 郜青霞. 中西医结合治疗子宫内膜异位症性不孕症临床观察[J]. 中国中医药信息杂志, 2007, 14(10): 58-59. | | [29] | 苏燕燕. GnRHa联合桂枝茯苓胶囊对卵巢巧克力囊肿腹腔镜剥除术后康复及卵巢功能和妊娠结局的影响[J]. 现代中西医结合杂志, 2018, 27(8): 843-846. | | [30] | 周莉, 葛军, 梁莹, 等. 疏肝化瘀方对体外受精-胚胎移植周期妊娠结局及GDF-9的影响[J]. 中国优生与遗传杂志, 2015, 23(10): 114-115, 120. | | [31] | 连方, 李晓娜. 丹莪妇康煎膏提高子宫内膜异位症体外受精——胚胎移植患者卵细胞质量及GDF-9表达的研究[J]. 中国中西医结合杂志, 2013, 33(9): 1179-1182. | | [32] | 沈颖. 滋肾凉血调周法对子宫内膜异位症合并不孕患者子宫内膜容受性的影响[D]: [硕士学位论文]. 杭州: 浙江中医药大学, 2016. | | [33] | 庄梦斐, 张婷婷, 孙兆贵, 等. 清热化瘀法对子宫内膜异位症大鼠血管生成和炎症相关因子表达的影响[J]. 中华中医药杂志, 2016, 31(5): 1595-1599. | | [34] | 林静, 王志美, 徐洋, 等. 活血化瘀汤联合孕三烯酮治疗子宫内膜异位症的疗效观察[J]. 陕西中医, 2017, 38(11): 1546-1547. | | [35] | 杨桂云, 刘红林. 补肾活血方对子宫内膜异位症不孕腹腔液微环境改善作用的实验研究[J]. 中医药学刊, 2003, 21(1): 57-59. | | [36] | 刘莉芬. 补肾散结解毒汤对子宫内膜异位症伴黄体功能不全性不孕症的影响[J]. 按摩与康复医学, 2019, 10(3): 29-30. | | [37] | 蒋会芹. 丹赤饮治疗子宫内膜异位症相关不孕症随机平行对照研究[J]. 实用中医内科杂志, 2015, 29(4): 38-40. | | [38] | 谢蓬蓬. 罗氏内异方联合腹腔镜手术对轻型子宫内膜异位症不孕患者血清Th1/Th2的影响[D]: [硕士学位论文]. 广州: 广州中医药大学, 2009. | | [39] | 施锦梅, 朱茵. 补肾活血化瘀中药联合腹腔镜手术对子宫内膜异位症不孕患者性激素、氧化应激及生育情况的影响[J]. 中国妇幼保健, 2019, 34(24): 5740-5742. | | [40] | 杨玲. 腹腔镜联合活血化瘀汤治疗轻型子宫内膜异位症不孕患者疗效观察及对氧化应激状态的影响[J]. 新中医, 2016, 48(5): 177-179. | | [41] | 胡兴焕, 邹伟. 腹腔镜手术联合温肾活血中药治疗子宫内膜异位症疗效及对血清Th1/Th2、氧化应激水平的影响[J]. 现代中西医结合杂志, 2016, 25(9): 3208-3211. | | [42] | 杨学芳, 周菊英. 活血化瘀汤联合腹腔镜治疗轻型子宫内膜异位症不孕患者的疗效及对趋化因子和氧化应激因子的影响[J]. 湖北中医杂志, 2016, 38(7): 4-6. |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (8)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-10-14T06:23:58.021457+00:00
License: CC0 · commercial use OK