Eye to the Future in Adenomyosis Research

Halvorson LM, Lisa M. Halvorson, Giudice LC, Linda C. Giudice, Elizabeth A. Stewart, Stewart EA
Seminars in reproductive medicine · 2020 · vol. 38(02/03) , pp. 197–200 · doi:10.1055/s-0040-1721503 · PMID:33307559 · W3111013684
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This article summarizes current perspectives on future directions for basic, translational, and clinical research into adenomyosis, a poorly understood gynecologic disorder with significant morbidity.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This article is a narrative review summarizing the current state and future directions of basic, translational, and clinical research on adenomyosis, a disorder associated with dysmenorrhea, pelvic pain, heavy menstrual bleeding, infertility, and adverse pregnancy outcomes. Across epidemiology, risk factors, pathogenesis, pathophysiology, diagnosis, and treatment, it highlights substantial knowledge gaps and synthesizes recent concepts drawn from prior studies and research priorities. A stated limitation is that the paper summarizes “current thoughts” across many domains rather than presenting new original data. This paper is centrally about adenomyosis research — it outlines future directions spanning mechanisms, diagnosis, and treatment.

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Abstract

Adenomyosis is a poorly understood and clinically underappreciated gynecologic disorder associated with substantial morbidity including dysmenorrhea, pelvic pain, heavy menstrual bleeding, infertility, and poor pregnancy outcomes. Substantial gaps persist in our understanding of essentially all aspects of this disorder - epidemiology, risk factors, pathogenesis, pathophysiology, diagnosis, and treatment. In this article, we summarize current thoughts on future directions in basic, translational, and clinical adenomyosis research.
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Abstract

Adenomyosis is a poorly understood and clinically underappreciated gynecologic disorder associated with substantial morbidity including dysmenorrhea, pelvic pain, heavy menstrual bleeding, infertility, and poor pregnancy outcomes. Substantial gaps persist in our understanding of essentially all aspects of this disorder – epidemiology, risk factors, pathogenesis, pathophysiology, diagnosis, and treatment. In this article, we summarize current thoughts on future directions in basic, translational, and clinical adenomyosis research. Publication History Article published online: 11 December 2020 © 2020. Thieme. All rights reserved. Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA -

References

- 1 Taylor HS, Giudice LC, Lessey BA. et al. Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. N Engl J Med 2017; 377 (01) 28-40 - 2 Rogers PA, Adamson GD, Al-Jefout M. et al; WES/WERF Consortium for Research Priorities in Endometriosis. Research Priorities for Endometriosis. Reprod Sci 2017; 24 (02) 202-226 - 3 Stewart EA, Lytle BL, Thomas L, Wegienka GR, Jacoby V, Diamond MP. et al. The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design. Am J Obstet Gynecol 2018; 219 (01) 95e1-95e10 - 4 Vannuccini S, Petraglia F. Recent advances in understanding and managing adenomyosis. F1000 Res 2019; 8: 8 - 5 Zhai J, Vannuccini S, Petraglia F, Giudice L. Adenomyosis: mechanisms and pathogenesis. Semin Reprod Med 2020; 38: 129-143 - 6 Yeh CC, Su FH, Tzeng CR, Muo CH, Wang WC. Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. PLoS One 2018; 13 (03) e0194011 - 7 Guo S, Li Z, Yan L, Sun Y, Feng Y. GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Des Devel Ther 2018; 12: 1621-1631 - 8 Razavi M, Maleki-Hajiagha A, Sepidarkish M, Rouholamin S, Almasi-Hashiani A, Rezaeinejad M. Systematic review and meta-analysis of adverse pregnancy outcomes after uterine adenomyosis. Int J Gynaecol Obstet 2019; 145 (02) 149-157 - 9 Habiba M, Pluchino N, Petignat P, Bianchi P, Brosens IA, Benagiano G. Adenomyosis and Endometrial Cancer: Literature Review. Gynecol Obstet Invest 2018; 83 (04) 313-328 - 10 Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand 2010; 89 (11) 1374-1384 - 11 Loring M, Chen T, Isaacson K. Symptoms of adenomyosis and overlapping diseases. Semin Reprod Med 2020; 38: 144-152 - 12 O'Shea A, Figueiredo G, Lee S. Imaging diagnosis of adenomyosis. Semin Reprod Med 2020; 38: 119-128 - 13 Acar S, Millar E, Mitkova M, Mitkov V. Value of ultrasound shear wave elastography in the diagnosis of adenomyosis. Ultrasound 2016; 24 (04) 205-213 - 14 Antero MF, Ayhan A, Segars J, Shih I. Pathology and pathogenesis of adenomyosis. Semin Reprod Med 2020; 38: 108-118 - 15 Herndon CN, Aghajanova L, Balayan S. et al. Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis. Reprod Sci 2016; 23 (10) 1289-1303 - 16 Munro MG. Classification and Reporting Systems for Adenomyosis. J Minim Invasive Gynecol 2020; 27 (02) 296-308 - 17 Tsang JYS, Tse GM. Molecular Classification of Breast Cancer. Adv Anat Pathol 2020; 27 (01) 27-35 - 18 Marquardt R, Jeong JW, Asgerally T, Fazleabas A. Animal models of adenomyosis. Semin Reprod Med 2020; 38: 170-180 - 19 Gnecco J, Brown A, Kan E. et al. Physiomimetic models of adenomyosis. Semin Reprod Med 2020; 38: 181-198 - 20 Cope AG, Ainsworth AJ, MD Stewart EA. Current and future medical therapies for adenomyosis. Semin Reprod Med 2020; 38: 153-158 - 21 Chen J, Porter AE, Kho K. Current and future surgical and interventional management options for adenomyosis. Semin Reprod Med 2020; 38: 159-169

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Condition tags

adenomyosisdysmenorrheainfertility

MeSH descriptors

Adenomyosis Research Adenomyosis Adenomyosis Animals Disease Models, Animal Female Humans Pregnancy Research

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

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