Adenomyosis and Endometrial Cancer: Literature Review

Marwan Habiba, Nicola Pluchino, Patrick Petignat, Paola Bianchi, Ivo A Brosens, Ivo Brosens, Giuseppe Benagiano
Gynecologic and obstetric investigation · 2018 · vol. 83(4) , pp. 313–328 · doi:10.1159/000487320 · PMID:29874641 · W2805756485
review OA: closed CC0 ⤵ 37 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This literature review examines the relationship between adenomyosis and endometrial cancer, exploring disease origin, risk, invasiveness, prognosis, and potential interactions between the two conditions.

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Abstract

To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrial Neoplasms Adenomyosis Adenomyosis Endometrial Neoplasms Endometrial Neoplasms Endometrium Endometrium Female Humans Middle Aged Myometrium Myometrium Prognosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (99)

Cited by (37)

Source provenance

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License: CC0 · commercial use OK