Adenomyosis and Endometrial Cancer: Literature Review

Marwan Habiba, Habiba M, Nicola Pluchino, Patrick Petignat, Bianchi P, Paola Bianchi, Ivo A Brosens, Brosens IA, Ivo Brosens, Benagiano G, Giuseppe Benagiano
Gynecologic and obstetric investigation · 2018 · vol. 83(4) , pp. 313–328 · doi:10.1159/000487320 · PMID:29874641 · W2805756485
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This literature review examines the relationship between adenomyosis and endometrial cancer, exploring disease origin, risk, invasiveness, prognosis, and potential interactions between the two conditions.

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This literature review examines the potential association between adenomyosis and the development of endometrial cancer by synthesizing existing clinical and pathological data. The authors analyze whether adenomyosis acts as an independent risk factor or a confounding variable in patients diagnosed with endometrial neoplasms, highlighting shared hormonal drivers such as estrogen exposure. While some studies suggest a correlation due to overlapping symptoms and histological features, the paper notes that definitive causal links remain difficult to establish due to limited large-scale longitudinal evidence. This paper is centrally about endometriosis and adenomyosis research — specifically evaluating the pathological relationship between adenomyosis and endometrial cancer.

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Abstract

To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.
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Adenomyosis and Endometrial Cancer: Literature Review Published inGynecologic and Obstetric Investigation, vol. 83, no. 4, p. 313-328 Publication date2018 Abstract Keywords - Adenomyosis/complications/pathology - Endometrial Neoplasms/etiology/pathology - Endometrium/pathology - Female - Humans - Middle Aged - Myometrium/pathology - Prognosis Affiliation entities Research groups Citation (ISO format) HABIBA, Marwan et al. Adenomyosis and Endometrial Cancer: Literature Review. In: Gynecologic and Obstetric Investigation, 2018, vol. 83, n° 4, p. 313–328. doi: 10.1159/000487320 Main files (1) Article (Published version) Identifiers - PID : unige:111649 - DOI : 10.1159/000487320 - PMID : 29874641 Journal ISSN0378-7346

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrial Neoplasms Adenomyosis Adenomyosis Endometrial Neoplasms Endometrial Neoplasms Endometrium Endometrium Female Humans Middle Aged Myometrium Myometrium Prognosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (99)

Cited by (37)

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