Clear Cell Adenocarcinoma Arising From Adenomyosis

Kenichi Hirabayashi, Masanori Yasuda, Yasuda M, Hiroshi Kajiwara, Kajiwara H, Nakamura N, Naoya Nakamura, Sato S, Shigeru Sato, Yoshihiro Nishijima, Nishijima Y, Mikio Mikami, R. Yoshiyuki Osamura, Robert Yoshiyuki Osamura, Osamura RY
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2009 · vol. 28(3) , pp. 262–266 · doi:10.1097/pgp.0b013e31818e101f · PMID:19620944 · W2041100234
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This case report describes a 73-year-old woman with a clear cell adenocarcinoma arising from adenomyosis, presenting as an intramyometrial tumor with elevated CA125.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-18 · read from full text ⓘ

This case report describes a 73-year-old postmenopausal woman presenting with fever, weight loss, and elevated CA125 levels who was ultimately diagnosed with clear cell adenocarcinoma arising from adenomyosis. Histological examination of the resected uterus revealed an intramyometrial tumor showing transitions between benign adenomyotic epithelium and both noninvasive and invasive carcinoma, confirmed by hepatocyte nuclear factor-1β immunohistochemistry. The authors note that this is only the second English-language document describing such a malignancy and emphasize that malignant transformation within adenomyosis should be considered in differential diagnoses for patients with high tumor markers and intramyometrial masses. This paper is centrally about adenomyosis — specifically documenting a rare case of clear cell adenocarcinoma developing from adenomyotic tissue.

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Abstract

A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA, and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1beta supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.
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Clear Cell Adenocarcinoma Arising From Adenomyosis - Kenichi Hirabayashi - Masanori Yasuda - Hiroshi Kajiwara - Naoya Nakamura - Shigeru Sato - Yoshihiro Nishijima - Mikio Mikami - Robert Yoshiyuki Osamura A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA, and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1β supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Uterine Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Aged CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Female Humans Immunohistochemistry Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

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