Clear Cell Adenocarcinoma Arising From Adenomyosis

Kenichi Hirabayashi, Masanori Yasuda, Hiroshi Kajiwara, Naoya Nakamura, Shigeru Sato, Yoshihiro Nishijima, Mikio Mikami, Robert Yoshiyuki Osamura, R. Yoshiyuki Osamura
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2009 · vol. 28(3) , pp. 262–266 · doi:10.1097/pgp.0b013e31818e101f · PMID:19620944 · W2041100234
article OA: closed CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes a 73-year-old woman with a clear cell adenocarcinoma arising from adenomyosis, presenting as an intramyometrial tumor with elevated CA125.

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Abstract

A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA, and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1beta supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Uterine Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Aged CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Female Humans Immunohistochemistry Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (16)

Source provenance

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