Clear cell adenocarcinoma arising from adenomyotic cyst: A case report and literature review
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This case report describes a rare clear cell adenocarcinoma arising from a uterine adenomyotic cyst in a 40-year-old woman and reviews diagnostic features for this entity.
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Abstract
Ovaries are the primary sites of cancerous disease that is derived from endometriosis. Uterine cancer originating from endometriosis is very rare. The most frequent histological subtype of cancer derived from endometriosis is endometrioid adenocarcinoma, a subtype of clear cell carcinoma which is exceedingly rare. We report a case of a 40-year-old Japanese woman with a six year history of uterine leiomyoma. The patient was clinically and radiologically suspected to have degenerative uterine myoma with a possible malignant association and underwent a transabdominal total hysterectomy. Histopathological examination of the specimens revealed clear cell adenocarcinoma arising from the adenomyotic cyst. A literature review of clear cell adenocarcinomas arising from uterine adenomyotic cysts (cystic adenomyosis), emphasizes the clinically and radiologically important features of this very rare entity. Clear cell carcinoma association should be suspected in patients who are under follow-up for uterine myomas and present with cystic uterine changes with solid component on magnetic resonance imaging or computed tomography scans.
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References (13)
- Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
- Clear Cell Adenocarcinoma Arising From Adenomyosis via openalex
- Clear cell adenocarcinoma arising from adenomyosis mimicking leiomyoma: A case report via openalex
- Clear cell adenocarcinoma arising from a giant cystic adenomyosis: A case report with immunohistochemical analysis of laminin-5 gamma2 chain and p53 overexpression via openalex
- Endometrial adenocarcinoma with variable-level myometrial involvement limited to adenomyosis: A clinicopathologic study of 23 cases via openalex
- Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex
- Loss of ARID1A Expression Is an Early Molecular Event in Tumor Progression From Ovarian Endometriotic Cyst to Clear Cell and Endometrioid Carcinoma via openalex
- Ovarian cancer risk associated with varying causes of infertility via openalex
- Pathogenesis and malignant transformation of adenomyosis (Review) via openalex
- [Primary clear cell carcinoma arising in cystic adenomyosis of the uterus--a case report]. via openalex
- W2043128771 via openalex
- W1984029678 via openalex
- W2164168667 via openalex
Cited by (22)
- A case of undifferentiated carcinoma arising from adenomyosis 2026
- Unveiling a Genetic Link Between Adenomyosis and Carcinogenesis via Whole-Exome Sequencing: Could NTN1-Mediated Epithelial Mesenchymal Transition Be a Shared Mechanism? 2026
- Adenomyosis as a prognostic factor in ovarian cancer: a retrospective study 2025
- Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report 2024
- Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression 2024
- Carcinosarcoma of the uterus, derived from subserous cystic adenomyosis, presenting as an acute abdomen: A case report and review of the literature 2023
- Mucinous carcinoma originating from uterine adenomyosis: a case report 2023
- Adenomyosis and Its Possible Malignancy: A Review of the Literature 2023
- Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review 2023
- Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary - pulmonary type (SCOOPT): a case report and literature review 2022
- Ultrasound-Guided Transvaginal Aspiration and Sclerotherapy for Uterine Cystic Adenomyosis: Case Report and Literature Review 2022
- Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary-pulmonary type (SCCOPT): a case report and literature review 2022
- Uterine clear cell carcinoma arising from cystic adenomyosis: a case report 2021
- Pathology and Pathogenesis of Adenomyosis 2020
- The clinicopathological characteristics and survival outcomes of endometrial carcinoma coexisting with or arising in adenomyosis: A pilot study 2020
- Subserosal adenomyotic cysts and peritoneal inclusion cysts – Unusual differential diagnoses of multicystic pelvic masses: A review of two cases 2020
- Clear Cell Adenocarcinoma Originated from Adenomyosis 2019
- Malignant transformation of adenomyosis: literature review and meta-analysis 2018
- Ultrasound diagnosis of endometriosis and adenomyosis: State of the art 2018
- Adenomyosis and Endometrial Cancer: Literature Review 2018
- Cystic Adenomyosis 2018
- Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases 2016
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- europepmc
- last seen: 2026-06-22T06:15:23.361955+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:17:33.600579+00:00
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