Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer

Koji Matsuo, Sigita S Cahoon, Marc Gualtieri, M. Gualtieri, Christopher A Scannell, Carrie E Jung, Tadao Takano, Richard J Paulson, Laila I Muderspach, Lynda D Roman
Annals of surgical oncology · 2014 · vol. 21(13) , pp. 4246–4255 · doi:10.1245/s10434-014-3880-6 · PMID:25001096 · W2071408660
article OA: closed CC0 ⤵ 27 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Adenomyosis in endometrial cancer patients was associated with lower tumor grade, earlier stage, and better disease-free and overall survival outcomes.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective study evaluated stage I–IV endometrial cancer patients undergoing hysterectomy-based surgical staging (n=571) and women with endometrial hyperplasia undergoing hysterectomy (n=213), comparing clinicopathologic factors and survival outcomes by the presence or absence of adenomyosis. Among endometrial cancer cases, adenomyosis was present in 47.5% and was associated with less aggressive features, including lower tumor grade, earlier stage, and lower likelihood of deep myometrial and cervical invasion; in survival analyses, endometrial cancer coexisting with adenomyosis showed better disease-free and overall survival after hysterectomy, and adenomyosis remained an independent prognostic factor for decreased recurrence risk in multivariate models. A key limitation is the retrospective design and the observation-level nature of associations, which cannot establish causality. Relevance to endometriosis and/or adenomyosis: the paper is centrally about adenomyosis in relation to endometrial cancer progression and survival, directly addressing uterine adenomyosis as a modifier of tumor behavior.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrial Neoplasms Endometrial Neoplasms Myometrium Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenomyosis Adenomyosis Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Disease Progression Endometrial Neoplasms

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europepmc
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License: CC0 · commercial use OK