Correlation between Adenomyosis and Endometrial cancer: 6-year experience of a single center.

D Zouzoulas, O D Zouzoulas, D Tsolakidis, Dimitrios Tsolakidis, I Efstratiou, Ioannis Efstratiou, Stavroula Pervana, S Pervana, E Pazarli, G Grimbizis, Grigoris Grimbizis
Facts, views & vision in ObGyn · 2018 · vol. 10(3) , pp. 147–152 · PMID:31191849 · PMC6548412 · W2990648765
article OA: gold CC0 ⤵ 12 in-corpus citations
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This study of 229 endometrial cancer patients found that 28% also had adenomyosis, and 11% of those with both showed malignant transformation in the adenomyotic tissue.

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Abstract

INTRODUCTION: Adenomyosis often co-exists in the pathological specimens after surgery for endometrial cancer. The aim of this study is to describe the clinicopathological and oncological characteristics of these patients and further investigate the possibility of malignant transformation in the adenomyotic tissue. METHODS: We retrospectively reviewed the medical records of all patients that underwent hysterectomy for endometrial cancer (January 2012 - December 2017). The pathological reports were studied and when adenomyosis was present, the pathological slides were reviewed in order to discover any malignant change in the adenomyotic tissue. The clinicopathological characteristics and oncological results were described. RESULTS: Out of 229 cases of endometrial cancer, 64 (28%) patients had concurrently endometrial cancer and adenomyosis. Among these 64 patients, 7 (11%) had malignant transformation of adenomyosis. The mean age of patients suffering from both endometrial cancer and adenomyosis was 63.2 years old and 57 (89%) of these patients, had early endometrial cancer. Concerning the patients with malignant transformation of adenomyosis, their mean age was 65 years old with no premenopausal case. DISCUSSION: Adenomyosis has been described in the last decades, but its malignant transformation into endometrial cancer is not fully undercovered. Further investigation is needed in order to clarify the pathologic progression of adenomyotic lesions to endometrial cancer.

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adenomyosis

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