Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium?

Musa F, Fernanda Musa, Melissa K Frey, Im HB, H Beatrice Im, Hyoung‐June Im, Chekmareva M, Marina Chekmareva, Lora H Ellenson, Ellenson LH, Kevin Holcomb, Holcomb K
American journal of obstetrics and gynecology · 2012 · vol. 207(5) , pp. 417.e1–417.e6 · doi:10.1016/j.ajog.2012.06.051 · PMID:22840974 · W2088540400
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This study investigated whether adenomyosis and lymphovascular space invasion influence lymph node metastasis in patients diagnosed with endometrioid adenocarcinoma of the endometrium.

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Abstract

ObjectiveWe sought to determine the prevalence of adenomyosis and assess its effect on lymph node status in endometrioid adenocarcinoma of the endometrium (EAC).Study designHysterectomy specimens from a single institution were reviewed for the presence of adenomyosis, lymphovascular space invasion (LVSI), tumor grade, histology, and lymph node status. Standard statistical analysis was used to compare variables.ResultsAdenomyosis was present in 42% of total and 66% of malignant hysterectomy specimens (P = .009). Adenomyosis was most commonly associated with EAC histology (P = .023). LVSI was found to be an independent predictor of lymph node metastasis in EAC patients without adenomyosis, but not in those with coexisting adenomyosis (odds ratio, 58.7; P = .03; and odds ratio, 4.98; P = .15; respectively).ConclusionAdenomyosis was associated with a lower risk of lymph node metastasis in EAC patients with LVSI. Further studies are needed to investigate the role of adenomyosis in lymphatic tumor infiltration.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Carcinoma, Endometrioid Endometrial Neoplasms Adenomyosis Adenomyosis Adenomyosis Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Female Humans Hysterectomy Lymphatic Metastasis Lymph Node Excision Middle Aged Neoplasm Invasiveness

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