Endometrial Tissue in Myometrial Vessels not Associated with Menstruation
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Endometrial tissue within myometrial vessels was observed in 14 women with extensive adenomyosis, suggesting a possible origin from perivascular cells rather than menstruation.
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Abstract
The presence of endometrial tissue in myometrial vessels has been described in the literature primarily in association with the menstrual period. We reviewed 277 hysterectomy specimens to assess the frequency of endometrial tissue in myometrial vessels in the uteri of nonmenstruating women. Intravascular endometrial tissue was observed in 14 cases, all of which showed extensive adenomyosis usually present in multiple foci. None of the uteri without adenomyosis showed intravascular endometrial tissue. In foci of adenomyosis, the intimate relationship of endometrial tissue and vessels might be explained by the possible origin of endometrial tissue from uncommitted perivascular cells, a possibility that is supported by our failure to demonstrate a connection between the foci of adenomyosis and endometrium in serial sections. When the uncommitted perivascular cells proliferate, they may impinge on endothelially intact vascular lumina and later become intraluminal. Pathologists should be aware of this phenomenon associated with adenomyosis to avoid interpreting the cells within vessels as being neoplastic.
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Cited by (36)
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- Adenomiosis: diagnóstico 2023
- RETROSPECTIVE ANALYSIS OF CHANGING TRENDS IN PRESENTATION AND MANAGEMENT OF ADENOMYOSIS 2022
- Coexistence of uterine adenomyosis is not associated with a better prognosis in endometrioid-type endometrial cancer 2020
- Faculty Opinions recommendation of The impact of adenomyosis on women's fertility. 2019
- Uterine intravascular adenomyomatosis: a bizarre hybrid lesion? 2018
- Benign Diseases of the Endometrium 2018
- Cystic Adenomyosis 2018
- Endometriosis origin from primordial germ cells 2017
- The Effect of Adenomyosis in Myometrial Invasion and Overall Survival in Endometrial Cancer 2017
- The Pathophysiology of Adenomyosis 2015
- Effects of Levonorgestrel-Releasing Intrauterine System on Lymphangiogenesis of Adenomyosis 2015
- The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis 2015
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Diagnóstico de la adenomiosis 2014
- Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium? 2012
- The pathophysiology of uterine adenomyosis: an update 2012
- Intravascular Endometrium Mimicking Vascular Invasion 2011
- Pseudoneoplastic lesions of the female genital tract. 2010
- Vascular Involvement in Adenomyosis: Report of a Large Series of a Common Phenomenon With Observations on the Pathogenesis of Adenomyosis 2010
- Mesenchymal uterine tumors, other than pure smooth muscle neoplasms, and adenomyosis 2009
- Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis 2009
- Adénomyose 2007
- Hormone-dependent gynaecological disorders: a pathophysiological perspective for appropriate treatment 2007
- Laparoscopic excision of uterine adenomyomas 2007
- Myometrial hyperplasia in pediatric, adolescent, and young adult uteri 2003
- Letter to the Editor 2003
- 10.1016/s0246-1064(21)43899-5 2000
- 10.1016/s0246-1064(13)59690-3 2000
- Aggressive endometriosis: report of a case 2000
- An effective minimally invasive method of treating adenomyosis by interstitial laser photocoagulation with the KTP laser 1997
- Intravascular endometrial tissue in an ovary of a patient with abnormal endometrial histology 1994
- Case Report INTRAVASCULAR ENDOMETRIAL TISSUE IN AN OVARY OF A PATIENT WITH ABNORMAL ENDOMETRIAL HISTOLOGY 1994
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