Adenomyosis and Endometrial Carcinoma

In: Uterine Adenomyosis · 2015 · pp. 153–161 · doi:10.1007/978-3-319-13012-5_10 · W2298111494
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This paper reviews the debated link between adenomyosis and endometrial cancer, noting cases of cancer within ectopic endometrium and the diagnostic challenges.

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This chapter examines whether adenomyosis predisposes to endometrial cancer, given its proposed links to hyper-estrogenism and increased “invasiveness,” while also noting that early, non-invasive diagnosis is difficult. It summarizes that research is hindered by challenges in determining whether cancer arises in eutopic versus ectopic endometrium, including the rarity of reports describing cancer identified solely in ectopic endometrium within the myometrium. The chapter reports that cancer present within adenomyosis does not appear to adversely affect prognosis, while emphasizing caution due to the limited number of published studies. This paper is centrally about endometriosis and adenomyosis — specifically, it focuses on adenomyosis and its debated relationship to endometrial carcinoma, with endometriosis mentioned in the broader context of hormone-dependent uterine conditions.

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Abstract

Although adenomyosis has been linked to hyper-estrogenism and with increased endometrial “invasiveness”, whether adenomyosis predisposes to endometrial cancer remains a matter of debate. Literature contains few case reports of cancer identified solely in the ectopic endometrium within the myometrium. The origin of cancer detected in both eutopic and ectopic endometrium is difficult to determine and research in this area remains hampered because of the difficulty of early and non-invasive diagnosis. The presence of cancer within adenomyosis does not seem to adversely affect prognosis, but caution should be exercised because of the limited number of published studies. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Springer, Cham. https://doi.org/10.1007/978-3-319-13012-5_10 Download citation DOI: https://doi.org/10.1007/978-3-319-13012-5_10 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-13011-8 Online ISBN: 978-3-319-13012-5 eBook Packages: MedicineMedicine (R0)

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