P53 Expression in Adenomyosis in Endometrial Carcinoma Patients
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This study investigated the expression levels of p53 protein within adenomyotic tissue collected from patients diagnosed with endometrial carcinoma.
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Abstract
Histopathologic changes ranging from simple cystic hyperplasia to carcinoma in situ may be observed in adenomyotic foci in patients with endometrial carcinoma. These changes can be an area of concern and physicians should be aware of their clinicopathologic significance. We studied a total of 94 patients, including endometrial carcinoma with (28 patients) and without adenomyosis (56 patients), and control group of adenomyosis cases (10 patients) without endometrial carcinoma. The histopathological changes in adenomyosis in patients with endometrial carcinoma varied from endometrial glands resembling the basal endometrium (13 of 28) through simple hyperplasia (8 of 28) to complex atypical hyperplasia, resembling carcinoma in situ (7 of 28). Formalinfixed paraffin-embedded tissues from 55 patients (45 endometrial carcinomas and 10 control adenomyosis) were stained with monoclonal antibodies against P53. P53 positivity was not detected in adenomyosis cases without endometrial carcinoma but was present in 7 of the endometrial carcinoma-related cases. P53 positivity was found in 14 of 45 endometrial carcinomas studied. In all of the adenomyosis-positive cases, the endometrium was also positive. In conclusion, adenomyosis with a range of hyperplastic to atypical changes is not uncommon in adenocarcinoma patients. Our findings regarding P53 positivity in adenomyosis are consistent with the hypothesis that hyperplastic and atypical changes in adenomyosis might be due to a carcinogenic field effect in the vicinity of endometrial carcinoma rather than by direct invasion.
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References (3)
- Carcinoma developing in areas of adenomyosis. via openalex
- The incidence of endometriosis interna in 120 cases of carcinoma of the endometrium via openalex
- W242819591 via openalex
Cited by (19)
- Expressão das proteínas reguladoras da biogênese dos miRNAs em lesões de adenomiose 2022
- Report of the National Cancer Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development–sponsored workshop: gynecology and women’s health–benign conditions and cancer 2020
- Adenomyosis As a Confounder to Accurate Endometrial Cancer Staging 2019
- Effects of Ovarian Pathologies and Uterine Inflammations on Adenomyosis in Bitches 2018
- Adenomyosis and Endometrial Cancer: Literature Review 2018
- Adenomyosis and Endometrial Carcinoma 2015
- Ovarian endometriosis as a premalignant condition: epidemiological, histological and molecular evidence 2012
- Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium? 2012
- Is adenomyosis associated with the risk of endometrial cancer? 2012
- Syndrome douloureux pelvien chronique de l'adénomyose utérine : critères diagnostiques et traitement conservateur Chronic pelvic pain syndrome due to uterine adenomyosis: diagnostic criteria and conservative treatment 2011
- Syndrome douloureux pelvien chronique de l’adénomyose utérine: critères diagnostiques et traitement conservateur 2010
- Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion 2007
- Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report 2007
- Adenomyosis is Associated With Myometrial Invasion by FIGO 1 Endometrial Adenocarcinoma 2007
- Immunohistochemical Expression of p53, MDM2, and p21Wafi Oncoproteins in Endometriomas But Not Adenomyosis 2005
- Adénocarcinome endométrioïde résultant de foyers d’adénomyose 2004
- Two kinds of endometrial neoplasia arising from different origins in the uterine corpus: comparison of p53 expression and sex steroid receptor status 2002
- Endometrioid adenocarcinoma arising from adenomyosis: Report and immunohistochemical analysis of an unusual case 2001
- Surgical and medical treatment of adenomyosis 1998
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