Immunohistochemical Expression of p53, MDM2, and p21Wafi Oncoproteins in Endometriomas But Not Adenomyosis

Anastasia G. Goumenou, Goumenou A, Anastasia Goumenou, Ioannis Panayiotides, Panayiotides I, Ioannis G. Panayiotides, Neal G Mahutte, Neal Mahutte, Mahutte NG, Ioannis Matalliotakis, Matalliotakis I, Yvoni Fragouli, Fragouli Y, Aydın Arıcı, Aydin Arici, Arici A
Journal of the Society for Gynecologic Investigation · 2005 · vol. 12(4) , pp. 263–266 · doi:10.1016/j.jsgi.2005.01.028 · PMID:15866118 · W1979579093
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This study investigated the expression of p53, MDM2, and p21Waf1 oncoproteins in endometriomas and adenomyosis, finding differential expression patterns between the two conditions.

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Abstract

Objectivep53, MDM2, and p21Waf1 are oncoproteins that regulate the cell cycle. The purpose of this study was to examine the distribution of p53, MDM2, and p21Waf1 oncoprotein expression in endometriomas and in adenomyosis.MethodsTissue samples from 25 women with pathologically confirmed endometriomas and 31 women with pathologically confirmed adenomyosis were analyzed. Expression of p53, MDM2, and p21Waf1 oncoproteins was assessed by immunohistochemical nuclear staining.Resultsp53, MDM2, and p21Waf1 expression were detected in 20%, 60%, and 80% of endometrioma tissue samples, respectively. All endometrioma tissue samples expressing p53 also tested positive for both MDM2 and p21Waf1. MDM2 expression was significantly higher in the proliferative than in the secretory phase of the cycle. In contrast, all 31 adenomyosis tissue samples were negative for p53, MDM2, and p21Waf1 expression.ConclusionThe expression of p53, MDM2, and p21Waf1 suggests a role for these oncoproteins in the regulation of endometrioma cell growth, but not in adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Cyclin-Dependent Kinase Inhibitor p21 Endometriosis Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 Adult Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Endometriosis Endometriosis Female Gene Expression Profiling Humans Immunohistochemistry Middle Aged Proto-Oncogene Proteins c-mdm2 Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 Tumor Suppressor Protein p53

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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