Adenomyosis As a Confounder to Accurate Endometrial Cancer Staging

Mahmoud A. Khalifa, Khalifa MA, Atri M, Mostafa Atri, Molly E Klein, Klein ME, Molly Klein, Ghatak S, Sayak Ghatak, Murugan P, Paari Murugan
Seminars in ultrasound, CT, and MR · 2019 · vol. 40(4) , pp. 358–363 · doi:10.1053/j.sult.2019.04.004 · PMID:31375175 · W2937947226
review OA: closed CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This paper investigates adenomyosis as a potential confounding factor that can lead to inaccurate staging of endometrial cancer.

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Abstract

The coexistence of endometrial adenocarcinoma and adenomyosis in the same uterus is a common phenomenon. In many of such affected patients foci of adenomyosis could also be colonized by adenocarcinoma. The various permutations arising from these scenarios pose preoperative imaging and postoperative pathologic staging challenges. This article aims to raise awareness of these staging issues and lists some of the relevant practical approaches. Adenomyosis reduces the accuracy of magnetic resonance imaging in assessing the depth of invasion as it reduces the contrast between the endometrial cancer adenomyosis-involved myometrium. The article also offers an alternate argument for staging cancers where myoinvasion is found deep in the myometrium, arising from cancer-positive adenomyotic foci when the surface tumor is either limited to the endometrium or to the inner half of myometrium.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Endometrial Neoplasms Endometrial Neoplasms Magnetic Resonance Imaging Adenomyosis Endometrial Neoplasms Endometrium Endometrium Endometrium Female Humans Magnetic Resonance Imaging Neoplasm Staging

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (50)

Cited by (17)

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License: CC0 · commercial use OK