Endometrial Clear Cell Carcinoma with Leiomyoma and Adenomyosis in a Postmenopausal Lady - A Case Report with Review

Pranita Mohanty, Anima Hota, Ajit S. Mohapatra, Tulasi Govardhan
In: Archives of Medicine and Health Sciences · 2022 · vol. 10(1) , pp. 109–111 · doi:10.4103/amhs.amhs_224_21 · W4285107219
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This case report describes a postmenopausal woman with endometrial clear cell carcinoma, uterine leiomyomas, and adenomyosis, investigating the potential clinicopathological correlation and prognostic significance of this rare coexistence.

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Abstract

Endometrial cancer (EC) is the 6 th most common cancer in women and endometrial clear cell carcinoma (CCC) comprised 2% of it. The association of uterine leiomyoma (UL) and adenomyosis (AM) with endometrioid variant of EC is well established, especially in postmenopausal women. Although the pathogenesis is still debatable, their presence with CCC is extremely uncommon. Moreover, the relation between CCC, AM, and UL is not yet validated because of limited data. Here, we report such a case of CCA associated with leiomyoma and AM in a 58-year-old postmenopausal Indian woman who presented with complaints of vaginal bleeding and watery discharge. She underwent hysterectomy and histopathology revealed CCC with multiple ULs and foci of AM, but there was no evidence of tumor transitioning from adenomyotic foci. This case study was aimed to evaluate if there really exists any clinicopathological correlation, tumor progression, and prognostic significance or simply this was a coexistence of all three entities.

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adenomyosis

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