Does coexistence of endometrial cancer and adenomyosis affect survival outcomes? A retrospective cohort study

Latife Gözde Buyuksahin, Azize Cemre ÖZTÜRK, Vakkaş Korkmaz, Şadıman Kıykaç Altınbaş, Yaprak Engin Üstün, O Houri, Y Gil, O Gemer, L Helpman, Z Vaknin, O Lavie, B Pecorino, A Lagan, V Chiantera, M Ferrara, Di Stefano, A, Di Donna, M, A Lindfors, H Heshar, C Adok, K Sundfeldt, P Dahm-Khler, K Matsuo, S Matsuzaki, D Nusbaum, H Machida, Y Nagase, B Grubbs, C Chapron, S Vannuccini, P Santulli, M Abro, F Carmona, I Fraser, M Hermens, A Van Altena, I Velthuis, Dcm Van De Laar, J Bulten, Haam Van Vliet, M Bourdon, L Marcellin, C Maignien, L Maitrot-Mantelet, C Bordonne, X Li, X Liu, S Guo, M Van Der Aa, A Siebers, K Hanley, S Dustin, M Stoler, K Atkins, C Bergeron, F Amant, A Ferenczy, I Rowlands, C Nagle, A Spurdle, P Webb, M An, H Duan, Y Zhang, M Szubert, E Kozirog, J Wilczynski, A Yilmaz, H Cokmez, A Gulbahar, J Da Silva, M Andres, Apk Leite, Mtna Gomes, J Neto, E Baracat, C Palena, D Hamilton, R Fernando, K Aslan, M Sar, H Yaln, Yaln, Z Cylan, B zdal, gder, H Doru, A zsoy, B akmak, Deliba, A Arici, K Upson, S Missmer, S Bulun, S Yildiz, M Adli, J Wei, K Khan, A Fujishita, T Mori, N Pan, W Zhang, Y Wang, Y Ge, H Wei, H Hu, H Li, Y He, M Maeda, S Cahoon, C Scannell, J Garcia-Sayre, L Roman, S Johnatty, Cjr Stewart, D Smith, A Nguyen, O' Dwyer, J, O 'mara, T, J Yun, L Jong-Min, Y Seung, A Taneichi, H Fujiwara, Y Takahashi, Y Takei, S Machida, Y Saga, A Raffone, A Travaglino, D Raimondo, M Maletta, P Salucci, A Santoro, A Murphy, H Campo, J Kim, F Musa, M Frey, H Im, M Chekmareva, L Ellenson, K Holcomb, M Gualtieri, C Jung, T Takano, M Koshiyama, T Okamoto, M Ueta, X Mao, W Zheng, W Mao, S Boonlak, A Aue-Aungkul, C Kietpeerakool, P Kleebkaow, B Chumworathayi, S Luanratanakorn
In: European Journal of Gynaecological Oncology · 2023 · doi:10.22514/ejgo.2023.112 · W4390240397
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the coexistence of adenomyosis with endometrial cancer did not significantly impact overall survival or disease-free survival in patients undergoing hysterectomy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This retrospective cohort study examined whether coexistence of adenomyosis in pathology specimens modifies survival outcomes among women treated for endometrial carcinoma at a tertiary center between 2010 and 2016. Of 370 patients with endometrial carcinoma who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, adenomyosis was present in 76 and absent in 287 after pathology review, and overall survival and disease-free survival were compared using mortality and time-to-death metrics. Mortality rates (9.2% vs 12.9%) and mean time from diagnosis to death (29.3 vs 44.6 months) did not differ significantly, and adenomyosis was not associated with overall survival (p=0.434) or disease-free survival (p=0.146). The authors’ main limitation is the retrospective, single-center design with the relatively small adenomyosis subgroup. This paper is centrally about adenomyosis in endometrial cancer and evaluates how adenomyosis coexistence affects survival outcomes.

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Abstract

The aim of this study is to investigate cancer survival parameters in patients with a combination of adenomyosis and endometrial carcinoma in pathological specimens. This is a retrospective cohort study conducted in a tertiary health center. Between January 2010 and December 2016, a total of 370 patients with a diagnosis of endometrial carcinoma who had undergone at least total abdominal hysterectomy and bilateral salpingoopherectomy. After excluding the patients from the pathology after reviewing the reports, 76 patients with adenomyosis were included in the study group and 287 patients without adenomyosis were included in the control group. The mean age of all patients was 63.6 ± 8.2 years. The mortality rate was 9.2% in patients with adenomyosis and 12.9% in patients without adenomyosis (p = 0.382). Overall, the mean time from diagnosis to death was 41.8 ± 24.7 months, which did not differ between patients with adenomyosis (29.3 ± 18 months) and without adenomyosis (44.6 ± 25.4 months, (p = 0.117). The presence of adenomyosis did not significantly affect overall survival (p = 0.434) or disease-free survival (p = 0.146). Median disease-free survival was 119 months in patients without adenomyosis and 120 months in patients with adenomyosis. None of the factors we studied affected survival in patients with adenomyosis. In our study, the presence of adenomyosis was found in 20.9% of patients who underwent hysterectomy for endometrial cancer, and this association had neither a positive nor a negative impact on disease prognosis, i.e., mortality rate, disease-free survival and overall survival.

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