Adenomyosis and coexisting gynecologic pathologies: How often do they coexist?

Hale Göksever Çelik, İpek Betül Özçivit Erkan, Ipek Betul Ozcivit Erkan, Elif Goknur Topcu, Elif Göknur Topçu, Isik Sozen, Işık Sözen, Nermin Gunduz, Nermin Gündüz, Cansu Turker Saricoban, Sennur Ilvan, Şennur İlvan, Fuat Demirkıran, Fuat Demirkiran, Engin Oral
International Journal of Gynecology & Obstetrics · 2025 · vol. 171(2) , pp. 728–735 · doi:10.1002/ijgo.70261 · PMID:40448421 · W4410922942
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⚙ AI-generated summary by claude@2026-06, 2026-06-04 ⓘ

This study evaluated 1455 hysterectomy specimens and found adenomyosis frequently coexists with myoma uteri, cancer, and endometrial polyps, with myomas being most common overall.

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Abstract

OBJECTIVE: To evaluate the presence of gynecologic pathologies accompanying adenomyosis among the hysterectomy specimens performed for various gynecologic indications. METHODS: This multicenter retrospective cohort study included women who underwent hysterectomy for various gynecologic indications and were diagnosed with adenomyosis at tertiary care centers. Eligible women were classified into two groups based on histopathologic results: Group 1-patients with only adenomyosis (n = 102) and Group 2-patients with adenomyosis and other gynecologic pathologies (n = 1353). Demographic and clinical characteristics, ultrasound examinations, and pathology reports were collected from medical records, and differences between the groups were assessed regarding clinical and demographic data, preoperative evaluations, and surgical characteristics. RESULTS: A total of 1455 patients were included. The adenomyosis-only group was significantly older than the group with other gynecologic pathologies. The most common coexisting condition was myoma uteri, found in 586 patients (43.3%), followed by cancer and endometrial polyp. Myoma uteri was the most common comorbidity in premenopausal women, but cancer was more prevalent in postmenopausal patients. The mean endometrial thickness was less in the adenomyosis-only group (6.5 ± 4.7 versus 8.0 ± 7.1 mm, P = 0.032). Adenomyosis was more frequent in patients with menstrual irregularities compared with pelvic pain and postmenopausal bleeding. Conversely, cancer was significantly more common in patients with postmenopausal bleeding. Overall, 351 (24.1%) patients were diagnosed with cancer, with endometrial cancer being the most common (n = 218, 62.1%). CONCLUSIONS: Our findings suggest that adenomyosis is frequently associated with conditions such as myoma uteri, endometrial polyps, and endometrial cancer.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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