Adenomyosis and accompanying gynecological pathologies

Mine Genç, Genc M, Mine Genc, Genc B, Berhan Genc, Berhan Genç, Hakan Cengiz, Cengiz H
Archives of gynecology and obstetrics · 2014 · vol. 291(4) , pp. 877–881 · doi:10.1007/s00404-014-3498-8 · PMID:25280573 · W1979809392
article OA: closed CC0 ⤵ 33 in-corpus citations
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-12 ⓘ

This retrospective study found adenomyosis is positively correlated with leiomyoma, previous abortions, previous pregnancies, and normal BMI, but not with smoking, normal/cesarean delivery, hyperplasia, or ovarian endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This retrospective study analyzed 945 women who underwent hysterectomy between 2005 and 2013, classifying 327 as having histopathologically confirmed adenomyosis and 618 without adenomyosis, to assess potential risk factors and relationships with accompanying gynecological pathologies and clinical characteristics. Adenomyosis showed significant positive correlations with the presence of leiomyoma, history of previous abortion and previous pregnancy, and a normal body mass index; it was not significantly associated with smoking, normal delivery, cesarean delivery, endometrial hyperplasia, or ovarian endometriosis. The authors conclude that multiparity with these factors may increase adenomyosis risk and that adenomyosis could be one cause of unexplained recurrent spontaneous abortion. This paper is centrally about adenomyosis — specifically its risk factors and associations with other gynecological pathologies (including lack of association with ovarian endometriosis in their cohort).

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

ObjectiveThe aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics.Materials and methodThis study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus.ResultsThere was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595).ConclusionWomen who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy.
Full text 5,468 characters · extracted from oa-doi-fallback · 5 sections · click to expand

Abstract

Objective The aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics.

Materials

and method This study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus.

Results

There was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595).

Conclusion

Women who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy. Similar content being viewed by others

References

Zaloudek C, Hendrickson MR (2002) Mesenchymal tumors of the uterus. In: Kurman RJ (ed) Blausteins’ pathology of the female genital tract, 5th edn. Springer, New York, pp 561–573 Rabinovici J, Inbar Y, Eylon SC, Schiff E, Hananel A, Freundlich D (2006) Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod 21(5):1255–1259 Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG (1997) Risk factors for adenomyosis. Hum Reprod 12(6):1275–1279 Bergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB (2001) Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod 16(11):2418–2421 Karaer O, Oruç S, Koyuncu FM (2004) Aromatase inhibitors: possible future applications. Acta Obstet Gynecol Scand 83(8):699–706 Bulun SE (2009) Endometriosis. N Engl J Med 360(3):268–279 Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P (2009) Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol 143(2):103–106 Bergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521 Ferenczy A (1998) Pathophysiology of adenomyosis. Hum Reprod Update 4(4):312–322 Kumar V, Cotran R, Robbins SL (1992) Basic Pathology, 5th edn. W.B. Saunders, Philadelphia, pp 615–616 Yeniel O, Cirpan T, Ulukus M, Ozbal A, Gundem G, Ozsener S, Zekioglu O, Yilmaz H (2007) Adenomyosis: prevalence, risk factors, symptoms and clinical findings. Clin Exp Obstet Gynecol. 34(3):163–167 Saleh SS, Fram K (2012) Histopathology diagnosis in women who underwent a hysterectomy for a benign condition. Arch Gynecol Obstet 285(5):1339–1343 Levgur M, Abadi MA, Tucker A (2000) Adenomyosis: symptoms, histology, and pregnancy terminations. Obstet Gynecol 95(5):688–691 Templeman C, Marshall SF, Ursin G, Horn-Ross PL, Clarke CA, Allen M, Deapen D, Ziogas A, Reynolds P, Cress R, Anton-Culver H, West D, Ross RK, Bernstein L (2008) Adenomyosis and endometriosis in the California Teachers Study. Fertil Steril 90(2):415–424 Martínez-Conejero JA, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simón C, Horcajadas JA, Pellicer A (2011) Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril 96(4):943–950 Jaslow CR (2014) Uterine factors. Obstet Gynecol Clin North Am 41(1):57–86 Yan L, Ding L, Tang R, Chen ZJ (2014) Effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection outcomes in infertile women: a retrospective cohort study. Gynecol Obstet Invest 77(1):14–18 Shrestha A (2012) Risk factors for adenomyosis. J Nepal Health Res Counc. 10(22):229–233 Vercellini P, Vigano P, Somigliana E, Daguati R, Abbiati A, Fedele I (2006) Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol 20:465–477 Donnez J (2012) Endometriosis: enigmatic in the pathogenesis and controversial in its therapy. Fertil Steril 98(3):509–510 Novellas S, Chassang M, Delotte J, Toullalan O, Chevallier A, Bouaziz J, Chevallier P (2011) MRI characteristics of the uterine junctional zone: from normal to the diagnosis of adenomyosis. AJR Am J Roentgenol 196(5):1206–1213 Morelli M, Rocca ML, Venturella R, Mocciaro R, Zullo F (2013) Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study. Gynecol Endocrinol 29(4):305–308 Conflict of interest This notice is to document that there is no conflict of interest. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Genc, M., Genc, B. & Cengiz, H. Adenomyosis and accompanying gynecological pathologies. Arch Gynecol Obstet 291, 877–881 (2015). https://doi.org/10.1007/s00404-014-3498-8 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-014-3498-8

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometrial Hyperplasia Endometriosis Hysterectomy Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Adenomyosis Adenomyosis Adult Case-Control Studies Cesarean Section Endometrial Hyperplasia Endometrial Hyperplasia Endometriosis Endometriosis Female Humans Leiomyoma Leiomyoma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (35)

Source provenance

europepmc
last seen: 2026-09-27T09:11:36.575535+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:15.805398+00:00
License: CC0 · commercial use OK