Uterine Artery Embolization for Symptomatic Adenomyosis: 7-Year Clinical Follow-up Using UFS-Qol Questionnaire

Annefleur M de Bruijn, Marieke Smink, Wouter J K Hehenkamp, Robbert J Nijenhuis, Albert J Smeets, Focco P. Boekkooi, Focco Boekkooi, Paul Reuwer, Paul J H M Reuwer, Willem Jan van Rooij, Willem J Van Rooij, Paul N M Lohle
Cardiovascular and interventional radiology · 2017 · vol. 40(9) , pp. 1344–1350 · doi:10.1007/s00270-017-1686-1 · PMID:28516272 · PMC5541078 · W2614932180
article OA: gold CC0 ⤵ 39 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Seven years after uterine artery embolization for symptomatic adenomyosis, health-related quality of life and symptom severity scores remained stable and improved, with 72% of patients satisfied and 82% avoiding hysterectomy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective cohort study from one hospital evaluated health-related quality of life and symptom severity 7 years after uterine artery embolization (UAE) in 29 women with MRI-confirmed symptomatic adenomyosis, either pure adenomyosis or adenomyosis with concurrent fibroids, using the UFS-QOL questionnaire. At 7 years (mean follow-up 95 months) HRQOL and symptom severity scores that had improved by 3 months remained broadly stable through follow-up, and 5 of 28 women (18%) underwent secondary hysterectomy; satisfaction was reported as at least fairly satisfied by 72% of patients. A key caveat is the modest sample size and questionnaire attrition (83% returned questionnaires, with additional outcomes collected by telephone), plus the paper notes group differences in baseline symptom severity. Relevance to endometriosis: the paper is centrally about adenomyosis (UAE outcomes assessed with UFS-QOL), which is closely related but does not explicitly focus on endometriosis.

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Abstract

PURPOSE: The purpose of this study was to assess clinical outcomes 7 years after uterine artery embolization (UAE) in the treatment of symptomatic adenomyosis. MATERIALS AND METHODS: In this prospective cohort study, one specialized hospital in the Netherlands recruited patients with symptomatic adenomyosis or adenomyosis in combination with fibroids for UAE. The 7-year post-intervention outcomes were health-related quality of life (HRQOL), symptom severity scores (SSS), satisfaction, menopause and re-interventions. RESULTS: Twenty-nine patients with adenomyosis (15 with fibroids) were treated with UAE between September 2006 and January 2010. The 7-year questionnaire was mailed in November 2016. The mean follow-up was 95 months (SD 9.0) at a mean age of 50 (SD 5.4). Questionnaires were returned by 24/29 patients (83%). The remaining five patients were contacted through telephone. One of these patients was untraceable. Seven years after treatment 5 of 28 patients (18%) underwent a secondary hysterectomy. The HRQOL and SSS scores as measured by UFS-QOL at 3 months after UAE showed significant improvement of -57 points (score: 15) and +40 points (score: 91), respectively. These scores remained comparable stable up unto 7 years. The SSS showed a significant difference of 17 points (0-100) in favor of the adenomyosis in combination with fibroids group (p = 0.020). Menopause was reported by 10/28 patients (36%). Twenty-one of 29 (72%) patients declared to be at least fairly satisfied about UAE. CONCLUSIONS: After 7 years of follow-up, in 82% of UAE-treated patients with symptomatic adenomyosis a hysterectomy was avoided.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Quality of Life Surveys and Questionnaires Uterine Artery Embolization Adenomyosis Adenomyosis Adenomyosis Adult Cohort Studies Female Follow-Up Studies Humans Hysterectomy Leiomyoma Leiomyoma Leiomyoma Leiomyoma Middle Aged Netherlands Prospective Studies

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