Asherman syndrome in adenomyosis treated with uterine artery embolization: incidence predictive factors

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This retrospective study of 195 adenomyosis patients found a 12.82% incidence of Asherman syndrome after uterine artery embolization, with low vascularity identified as a significant risk factor.

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This retrospective study evaluated 195 women with adenomyosis who underwent uterine artery embolization between 2009 and 2016, recording preoperative and intraoperative potential risk factors and monitoring for Asherman syndrome over 0–15 months. The incidence of Asherman syndrome events after UAE was 12.82% (25/195). Univariate and multivariate logistic regression identified low vascularity of the adenomyosis at the time of UAE as significantly associated with increased AS risk (P = 0.019). The authors’ limitation is that the analysis was retrospective, based on recorded risk factors, with follow-up limited to the stated monitoring window. This paper is centrally about adenomyosis — it analyzes incidence predictive factors for Asherman syndrome after uterine artery embolization, focusing specifically on lesion vascularity in adenomyosis.

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Abstract

PurposeTo investigate Asherman syndrome (AS) related to potential factors during uterine artery embolization (UAE) treatment of adenomyosis.Materials and methodsThis is a retrospective analysis of 195 women with adenomyosis who underwent UAE treatment from 2009 to 2016. All preoperative and intraoperative risk-related potential factors of AS were recorded. And AS events were carefully monitored during follow-up (range, 0-15 months). Potential risk-related factors of AS events were determined via univariate and multivariate logistic regression analyses.ResultsThe rate of AS events after UAE for adenomyosis was 12.82% (25/195). The univariate and multivariate analyses revealed the association of low vascularity with a significant risk for AS (P = 0.019).ConclusionPatients with low vascularity of adenomyosis at the time of UAE are more likely to have AS. And adenomyosis patients with low vascularity should be carefully selected to undergo UAE treatment.
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Abstract

Purpose To investigate Asherman syndrome (AS) related to potential factors during uterine artery embolization (UAE) treatment of adenomyosis.

Materials and methods

This is a retrospective analysis of 195 women with adenomyosis who underwent UAE treatment from 2009 to 2016. All preoperative and intraoperative risk-related potential factors of AS were recorded. And AS events were carefully monitored during follow-up (range, 0–15 months). Potential risk-related factors of AS events were determined via univariate and multivariate logistic regression analyses.

Results

The rate of AS events after UAE for adenomyosis was 12.82% (25/195). The univariate and multivariate analyses revealed the association of low vascularity with a significant risk for AS (P = 0.019).

Conclusion

Patients with low vascularity of adenomyosis at the time of UAE are more likely to have AS. And adenomyosis patients with low vascularity should be carefully selected to undergo UAE treatment. Similar content being viewed by others

References

Kim MD, Kim S, Kim NK, Lee MH, Ahn EH, Kim HJ, Cho JH, Cha SH (2012) Long-term results of uterine artery embolization for symptomatic adenomyosis. AJR Am J Roentgenol 188:176 Smeets AJ, Nijenhuis RJ, Boekkooi PF, Vervest HA, van Rooij WJ, Lohle PN (2012) Long-term follow-up of uterine artery embolization for symptomatic adenomyosis. Cardiovasc Intervent Radiol 35:815–819 Bratby MJ, Walker WJ (2009) Uterine artery embolisation for symptomatic adenomyosis-mid-term results. Eur J Radiol 70:128–132 Pelage JP, Jacob D, Fazel A, Namur J, Laurent A, Rymer R, Le Dref O (2005) Midterm results of uterine artery embolization for symptomatic adenomyosis: initial experience. Radiology 234:948–953 Tropeano G, Amoroso S, Di Stasi C et al (2014) Incidence and predictive factors for complications after uterine leiomyoma embolization. Hum Reprod 29:1918–1924 Moss JG, Cooper KG, Khaund A et al (2011) Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5-year results. Int J Obstet Gynaecol 118:936–944 Holub Z, Mara M, Kuzel D et al (2008) Pregnancy outcomes after uterine artery occlusion: prospective multicentric study. Fertil Steril 90(5):0–1891 Mara M, Kubinova K, Maskova J (2012) Uterine artery embolization versus laparoscopic uterine artery occlusion: the outcomes of a prospective nonrandomized clinical trial. Cardiovasc Int Radiol 35(5):1041–1052 Goldberg J, Pereira L, Berghella V et al (2004) Pregnancy outcomes after treatment for fibromyomata: uterine artery embolization versus laparoscopic myomectomy. Am J Obstet Gynecol 191(1):18–21 Walker WJ, Mcdowell SJ (2006) Pregnancy after uterine artery embolization for leiomyomata: a series of 56 completed pregnancies. Am J Obstet Gynecol 195(5):1266–1271 De Bruijn AM, Smink M, Lohle PNM et al (2017) Uterine artery embolization for the treatment of adenomyosis: a systematic review and meta-analysis. J Vasc Int Radiol 28(12):1629–1642 Song D, Liu Y, Xiao Y, Li TC, Zhou F, Xia E (2014) A matched cohort study comparing the outcome of intrauterine adhesiolysis for asherman syndrome after uterine artery embolization or surgical trauma. J Minim Invasive Gynecol 21:1022–1028 Spies JB, Spector A, Roth AR et al (2002) Complications after uterine artery embolization for leiomyomas. Obstet Gynecol 100(5):873–880 Ahmad A, Qadan L, Hassan N et al (2002) Uterine artery embolization for treatment of uterine fibroids: effect on ovarian function in younger women. J Vasc Interv Radiol 13(10):1017–1020 Lanciego C, Diazplaza I, Ciampi JuanJosé et al (2012) Utero-ovarian Anastomoses and Their Influence on Uterine Fibroid Embolization. J Vasc Int Radiol 23(5):595–601 Rashid S, Khaund A, Murray LS et al (2010) The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids. Bjog An Int J Obstet Gynaecol 117(8):985–989 Mara M, Fucikova Z, Kuzel D et al (2007) Hysteroscopy after uterine fibroid embolization in women of fertile age. Obstet Gynaecol Res 33:316–324 Mara M, Horak P, Kubinova K et al (2012) Hysteroscopy after uterine fibroid embolization: evaluation of intrauterine findings in 127 patients. Obstet Gynaecol Res 38:823–831 Chen CL, Xu YJ, Liu P et al (2013) Characteristics of vascular supply to uterine leiomyoma: an analysis of digital subtraction angiography imaging in 518 cases. Eur Radiol 23(3):774–779 Yixin T, Chunlin C, Hui D et al (2016) Low vascularity predicts favourable outcomes in leiomyoma patients treated with uterine artery embolization. Eur Radiol 26(10):1–9 Zhou J, He L, Liu P et al (2016) Outcomes in adenomyosis treated with uterine artery embolization are associated with lesion vascularity: a long-term follow-up study of 252 cases. PLoS ONE 11(11):e0165610 Listed NA (1988) The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, müllerian anomalies and intrauterine adhesions. Fertil Steril 49(6):944 Guo SW (2018) Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? Hum Reprod Update 24:1–22 Lohle PNM, Higué D (2019) Uterine artery embolisation in women with symptomatic adenomyosis. Presse Med 48:435–439 de Bruijn AM, Smink M, Hehenkamp WJK et al (2017) Uterine artery embolization for symptomatic adenomyosis: 7-year clinical follow-up using UFS-Qol questionnaire. Cardiovasc Intervent Radiol 40:1344–1350 Dessouky R, Gamil SA, Nada MG et al (2019) Management of uterine adenomyosis: current trends and uterine artery embolization as a potential alternative to hysterectomy. Insights Imaging 10:48 Isonishi S, Coleman RL, Hirama M et al (2008) Analysis of prognostic factors for patients with leiomyoma treated with uterine arterial embolization. Am J Obstet Gynecol 198(3):270e1–270e6 Kim MD, Lee M, Jung DC et al (2012) Limited efficacy of uterine artery embolization for cervical leiomyomas. J Vasc Interv Radiol 23(2):236–240 Zhou S, Yi T, Liu R et al (2012) Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics Mcp 11:3929–3936 Kitamura Y, Allison SJ, Jha RC, Spies JB, Flick PA, Ascher SM (2006) MRI of adenomyosis: changes with uterine artery embolization. AJR Am J Roentgenol 186:855–864 Park Y, Man DK, Jung DC et al (2015) Can measurement of apparent diffusion coefficient before treatment predict the response to uterine artery embolization for adenomyosis? Eur Radiol 25:1303–1309 Jung DC, Kim MD, Oh YT, Won JY, Lee DY (2012) Prediction of early response to uterine arterial embolisation of adenomyosis:value of T2 signal intensity ratio of adenomyosis. Eur Radiol 22:2044–2049 Lee CC, Reardon MA, Ball BZ et al (2015) The predictive value of magnetic resonance imaging in evaluating intracranial arteriovenous malformation obliteration after stereotactic radiosurgery. J Neurosurg 123:136–144 Dundr P, Mára M, Masková J, Fucíková Z, Povỳsil C, Tvrdík D (2006) Pathological findings of uterine leiomyomas and adenomyosis following uterine artery embolization. Pathol Res Pract 202:721–729 Discepola F, Valenti DA, Reinhold C (2007) Analysis of arterial blood vessels surrounding the myoma: relevance to myomectomy. Obstet Gynecol 110:1301–1303 Speir E, Shekhani H, Peters G (2017) Temporary anorgasmia following uterine artery embolization for symptomatic uterine fibroids. Cardiovasc Intervent Radiol 40:1–4 Bilhim T, Pisco JM (2010) The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of the post-embolization symptoms after uterine artery embolization. Pharmaceuticals 3:1729–1738 Zheng R, Zeng D, Wan TT et al (2018) Predisposing factors for predicting the therapeutic response of adenomyosis after uterine artery embolization: serum CA125 levels and accompanying endometriosis. Diagn Interv Radiol 24:364–371 Chen Y, Liu L, Luo Y, Chen M, Huan Y, Fang R (2016) Prevalence and impact of chronic endometritis in patients with intrauterine adhesions:a prospective cohort study. J Minim Invasive Gynecol 24:74–79 Dalton VK, Saunders NA, Harris LH, Williams JA, Lebovic DI (2006) Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure. Fertil Steril 85:1823(e1–3) Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. Consent for publication Consent for publication was obtained for every individual person’s data included in the study. Ethical approval All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975. Informed consent Informed consent was obtained from all individual participants included in the study. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Wang, Y., Lyu, W., Xu, W. et al. Asherman syndrome in adenomyosis treated with uterine artery embolization: incidence predictive factors. Radiol med 125, 437–443 (2020). https://doi.org/10.1007/s11547-020-01136-8 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s11547-020-01136-8

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Gynatresia Uterine Artery Embolization Adenomyosis Adenomyosis Adult Analysis of Variance Angiography, Digital Subtraction Endometrium Endometrium Female Follow-Up Studies Gynatresia Humans Middle Aged Organ Size Retrospective Studies Risk Factors Syndrome Uterine Artery Embolization

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