Uterine Artery Embolization to Treat Uterine Adenomyosis with or without Uterine Leiomyomata: Results of Symptom Control and Health-Related Quality of Life 40 Months after Treatment

V Froeling, Vera Froeling, Christian Scheurig‐Muenkler, C Scheurig-Muenkler, Bernd Hamm, B Hamm, T J Kroencke, Thomas Kroencke
Cardiovascular and interventional radiology · 2011 · vol. 35(3) , pp. 523–529 · doi:10.1007/s00270-011-0254-3 · PMID:21850565 · W2102487778
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Uterine artery embolization provided long-term symptomatic control and improved quality of life for women with adenomyosis, particularly when leiomyomata predominated.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study evaluated long-term outcomes 40 months after uterine artery embolization (UAE) in 40 women aged 39–56 with symptomatic uterine adenomyosis confirmed by magnetic resonance imaging, with or without concomitant uterine leiomyomata. Clinical response was assessed using self-perceived symptom changes, and residual symptom severity and health-related quality of life (HRQOL) were measured, with clinical failure defined as no symptomatic improvement or the need for a second invasive therapy after UAE. UAE achieved symptomatic control in 29 (72.5%) women; 11 underwent hysterectomy or dilatation and curettage for therapy failure, and there was no significant difference between pure adenomyosis versus combined adenomyosis with leiomyomata overall. HRQOL increased and symptom severity decreased after UAE, with the least improvement in women with pure adenomyosis, and the paper relates to endometriosis and adenomyosis research because it focuses on adenomyosis treatment outcomes after UAE.

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Abstract

Purpose To evaluate the clinical outcome for uterine adenomyosis with or without uterine leiomyomata 40 months after uterine artery embolization (UAE).

Methods

Forty women aged 39–56 years (median 46 years) with symptomatic uterine adenomyosis and magnetic resonance imaging findings of uterine adenomyosis with or without combined uterine leiomyomata underwent UAE. Self-perceived changes in clinical symptoms were assessed, and residual symptom severity and health-related quality of life (HRQOL) after UAE were evaluated. Clinical failure was defined as no symptomatic improvement or second invasive therapy after UAE. Results were stratified by the extent of uterine adenomyosis at baseline magnetic resonance imaging.

Results

Patients were followed for a median of 40 months (range 5–102 months). UAE led to symptomatic control after UAE in 29 (72.5%) of 40 patients while 11 women underwent hysterectomy (n = 10) or dilatation and curettage (n = 1) for therapy failure. No significant difference between women with pure uterine adenoymosis and women with uterine adenomyosis combined with uterine leiomyomata was observed. Best results were shown for UAE in uterine adenomyosis with uterine leiomyomata predominance as opposed to predominant uterine adenomyosis with minor fibroid disease (clinical failure 0% vs. 31.5%, P = 0.058). Throughout the study group, HRQOL score values increased and symptom severity scores decreased after UAE. Least improvement was noted for women with pure adenomyosis.

Conclusions

UAE is clinically effective in the long term in most women with uterine adenomyosis. Symptomatic control and HRQOL were highest in patients with combined disease of uterine adenomyosis but leiomyomata predominance. Similar content being viewed by others

References

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Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Embolization, Therapeutic Endometriosis Quality of Life Adult Chi-Square Distribution Dilatation and Curettage Embolization, Therapeutic Endometriosis Endometriosis Female Humans Hysterectomy Kaplan-Meier Estimate Leiomyoma Leiomyoma Leiomyoma Magnetic Resonance Imaging Microspheres Middle Aged Polyvinyl Alcohol

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