Current Trends and Future Strategies on Diagnosis and Management of Adenomyosis: An Updated Review

In: Current Womens Health Reviews · 2024 · vol. 21(3) · doi:10.2174/0115734048265172231018071749 · W4392854432
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This review discusses current and future management strategies for adenomyosis, a benign condition requiring lifelong care, focusing on medical and minimally invasive surgical treatments.

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This updated review compiles information on the diagnosis and management of adenomyosis, outlining how clinicians may address abnormal uterine bleeding, dysmenorrhea, dyspareunia, and infertility using medication or surgical options, with treatment choice influenced by age, reproductive status, and clinical indicators. It describes adenomyosis as benign endometrial tissue invading the myometrium and notes that it is typically diagnosed in women aged 30–50 and more often after childbirth, while emphasizing uterine-sparing strategies such as hormonal/pain management, hysteroscopic resection or ablation, conservative surgery, and high-intensity focused ultrasound, as well as growing use of uterine artery embolization. A major caveat stated in the review is that there is no medication approved specifically for adenomyosis, so the review focuses on existing and future medical procedures rather than established drug indications. Relevance to endometriosis: the paper explicitly cites a study on “Adenomyosis and endometriosis” and discusses their association via an MRI study, though the paper’s main focus is an updated overview of adenomyosis diagnosis and treatment strategies.

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Abstract

: This aim of the study was to gather information for use in the present and future management of the adenomyosis condition. Adenomyosis is a benign gynecological condition that needs to be managed for the rest of one's life with either medication or surgical treatment. It is also associated with abnormal uterine bleeding, dysmenorrhea, dyspareunia, and infertility. The choice a woman makes will be influenced by her age, reproductive status, and clinical indicators. The primary goals of this study were to gain knowledge on adenomyosis and to review potential treatment possibilities. According to this review, adenomyosis can be treated in a number of ways, including through medical attention utilizing least-invasive techniques a surgical operation that is performed with minimally invasive techniques. Focused ultrasound with high intensity (HIFU) for hysteroscopic ablation and resection Embolishing the uterine artery (UAE). Adenomyosis is a benign gynecological illness that necessitates a lifelong care strategy by medication or surgical therapy and is accompanied by abnormal uterine hemorrhage, dysmenorrhea, dyspareunia, and infertility. The option a woman chooses will depend on her age, reproductive status, and clinical signs. Since there is currently no medication approved for the treatment of adenomyosis, the present review will focus on existing and future medical procedures for the condition. The uterus is impacted by the medical condition adenomyosis. It happens when the endometrial tissue that normally lines the uterus invades the myometrium, the uterine muscle wall. Although this illness is benign, some people may experience substantial pain and discomfort as a result of it. It is more typically detected in those who have had children and is most frequently diagnosed in people between the ages of 30 and 50. Treatment options depend on the severity of symptoms and the individual's specific situation. Treatment approaches may include Pain Management, Hormonal Therapy, Surgical Interventions, Surgical Interventions and Lifestyle Changes. Several uterine-sparing therapeutic alternatives are currently available, each with unique risks and benefits, such as medication, hysteroscopic resection or ablation, conservative surgical methods, and high-intensity focused ultrasound. Uterine artery embolization, a practical, secure, and cost-effective method for treating uterine fibroids, has recently grown in popularity as a treatment for uterine adenomyosis.
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Abstract

This aim of the study was to gather information for use in the present and future management of the adenomyosis condition. Adenomyosis is a benign gynecological condition that needs to be managed for the rest of one's life with either medication or surgical treatment. It is also associated with abnormal uterine bleeding, dysmenorrhea, dyspareunia, and infertility. The choice a woman makes will be influenced by her age, reproductive status, and clinical indicators. The primary goals of this study were to gain knowledge on adenomyosis and to review potential treatment possibilities. According to this review, adenomyosis can be treated in a number of ways, including through medical attention utilizing least-invasive techniques a surgical operation that is performed with minimally invasive techniques. Focused ultrasound with high intensity (HIFU) for hysteroscopic ablation and resection Embolishing the uterine artery (UAE). Adenomyosis is a benign gynecological illness that necessitates a lifelong care strategy by medication or surgical therapy and is accompanied by abnormal uterine hemorrhage, dysmenorrhea, dyspareunia, and infertility. The option a woman chooses will depend on her age, reproductive status, and clinical signs. Since there is currently no medication approved for the treatment of adenomyosis, the present review will focus on existing and future medical procedures for the condition. The uterus is impacted by the medical condition adenomyosis. It happens when the endometrial tissue that normally lines the uterus invades the myometrium, the uterine muscle wall. Although this illness is benign, some people may experience substantial pain and discomfort as a result of it. It is more typically detected in those who have had children and is most frequently diagnosed in people between the ages of 30 and 50. Treatment options depend on the severity of symptoms and the individual's specific situation. Treatment approaches may include Pain Management, Hormonal Therapy, Surgical Interventions, Surgical Interventions and Lifestyle Changes. Several uterine-sparing therapeutic alternatives are currently available, each with unique risks and benefits, such as medication, hysteroscopic resection or ablation, conservative surgical methods, and high-intensity focused ultrasound. Uterine artery embolization, a practical, secure, and cost-effective method for treating uterine fibroids, has recently grown in popularity as a treatment for uterine adenomyosis.

Keywords

Adenomyosis, medical treatment, conservative surgical treatment, high-intensity focused ultrasound (HIFU), uterine artery embolization (UAE), reproductive status. [1] Bird, C.C.; McElin, T.W.; Manalo-Estrella, P. The elusive adenomyosis of the uterus-revisited. Am. J. Obstet. Gynecol., 1972, 112(5), 583-593. [http://dx.doi.org/10.1016/0002-9378(72)90781-8] [PMID: 5059589] [http://dx.doi.org/10.1016/0002-9378(72)90781-8] [PMID: 5059589] [2] Benagiano, G; Brosens, I. History of adenomyosis. Best Pract. Res. Clin. Obstet. Gynaecol., 2006, 20(1), 449-463. [http://dx.doi.org/10.1016/j.bpobgyn.2006.01.007] [http://dx.doi.org/10.1016/j.bpobgyn.2006.01.007] [3] García-Solares, J.; Donnez, J.; Donnez, O.; Dolmans, M.M. Pathogenesis of uterine adenomyosis: Invagination or metaplasia? Fertil. Steril., 2018, 109(3), 371-379. [http://dx.doi.org/10.1016/j.fertnstert.2017.12.030] [PMID: 29566849] [http://dx.doi.org/10.1016/j.fertnstert.2017.12.030] [PMID: 29566849] [5] Vercellini, P.; Parazzini, F.; Oldani, S.; Panazza, S.; Bramante, T.; Crosignani, P.G. Surgery: Adenomyosis at hysterectomy: A study on frequency distribution and patient characteristics. Hum. Reprod., 1995, 10(5), 1160-1162. [http://dx.doi.org/10.1093/oxfordjournals.humrep.a136111] [PMID: 7657758] [http://dx.doi.org/10.1093/oxfordjournals.humrep.a136111] [PMID: 7657758] [6] Bergholt, T.; Eriksen, L.; Berendt, N.; Jacobsen, M.; Hertz, J.B. Prevalence and risk factors of adenomyosis at hysterectomy. Hum. Reprod., 2001, 16(11), 2418-2421. [http://dx.doi.org/10.1093/humrep/16.11.2418] [PMID: 11679531] [http://dx.doi.org/10.1093/humrep/16.11.2418] [PMID: 11679531] [7] Parazzini, F.; Mais, V.; Cipriani, S.; Busacca, M.; Venturini, P. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Results from a prospective multicentric study in Italy. Eur. J. Obstet. Gynecol. Reprod. Biol., 2009, 143(2), 103-106. [http://dx.doi.org/10.1016/j.ejogrb.2008.12.010] [PMID: 19232812] [http://dx.doi.org/10.1016/j.ejogrb.2008.12.010] [PMID: 19232812] [8] Wallwiener, M.; Taran, F.A.; Rothmund, R.; Kasperkowiak, A.; Auwärter, G.; Ganz, A.; Kraemer, B.; Abele, H.; Schönfisch, B.; Isaacson, K.B.; Brucker, S.Y. Laparoscopic supracervical hysterectomy (LSH) versus total laparoscopic hysterectomy (TLH): An implementation study in 1,952 patients with an analysis of risk factors for conversion to laparotomy and complications, and of procedure-specific re-operations. Arch. Gynecol. Obstet., 2013, 288(6), 1329-1339. [http://dx.doi.org/10.1007/s00404-013-2921-x] [PMID: 23775263] [http://dx.doi.org/10.1007/s00404-013-2921-x] [PMID: 23775263] [9] Naftalin, J.; Hoo, W.; Pateman, K.; Mavrelos, D.; Holland, T.; Jurkovic, D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum. Reprod., 2012, 27(12), 3432-3439. [http://dx.doi.org/10.1093/humrep/des332] [PMID: 23001775] [http://dx.doi.org/10.1093/humrep/des332] [PMID: 23001775] [10] Di Donato, N; Montanari, G; Benfenati, A Prevalence of adenomyosis in women undergoing surgery for endometriosis. Eur. J. Obstet. Gynecol. Reprod Biol., 2014, 181, 289-293. [http://dx.doi.org/10.1016/j.ejogrb.2014.08.016] [http://dx.doi.org/10.1016/j.ejogrb.2014.08.016] [11] Tamai, K; Togashi, K; Ito, T; Morisawa, N; Fujiwara, T; Koyama, T. MR imaging findings of adenomyosis: Correlation with histopathologic features and diagnostic pitfalls. Radiographics, 2005, 25, 21-40. [http://dx.doi.org/10.1148/rg.251045060] [http://dx.doi.org/10.1148/rg.251045060] [12] Ascher, S.M.; Jha, R.C.; Reinhold, C. Benign myometrial conditions: Leiomyomas and adenomyosis. Top. Magn. Reson. Imaging, 2003, 14(4), 281-304. [http://dx.doi.org/10.1097/00002142-200308000-00003] [PMID: 14578775] [http://dx.doi.org/10.1097/00002142-200308000-00003] [PMID: 14578775] [14] Reinhold, C; Tafazoli, F; Mehio, A. Uterine adenomyosis: Endovaginal US and MR imaging features with histopathologic correlation. Radiographics, 1999, 19, S147-S160. [http://dx.doi.org/10.1148/radiographics.19.suppl_1.g99oc13s147] [http://dx.doi.org/10.1148/radiographics.19.suppl_1.g99oc13s147] [15] Dueholm, M.; Lundorf, E.; Hansen, E.S.; Sørensen, J.S.; Ledertoug, S.; Olesen, F. Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis. Fertil. Steril., 2001, 76(3), 588-594. [http://dx.doi.org/10.1016/S0015-0282(01)01962-8] [PMID: 11532486] [http://dx.doi.org/10.1016/S0015-0282(01)01962-8] [PMID: 11532486] [16] Bazot, M.; Cortez, A.; Darai, E.; Rouger, J.; Chopier, J.; Antoine, J.M.; Uzan, S. Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: Correlation with histopathology. Hum. Reprod., 2001, 16(11), 2427-2433. [http://dx.doi.org/10.1093/humrep/16.11.2427] [PMID: 11679533] [http://dx.doi.org/10.1093/humrep/16.11.2427] [PMID: 11679533] [17] Champaneria, R.; Abedin, P.; Daniels, J.; Balogun, M.; Khan, K.S. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: Systematic review comparing test accuracy. Acta Obstet. Gynecol. Scand., 2010, 89(11), 1374-1384. [http://dx.doi.org/10.3109/00016349.2010.512061] [PMID: 20932128] [http://dx.doi.org/10.3109/00016349.2010.512061] [PMID: 20932128] [18] Radzinsky, V.E.; Khamoshina, M.B.; Nosenko, E.N.; Dukhin, A.O.; Sojunov, M.A.; Orazmuradov, A.A.; Lebedeva, M.G.; Orazov, M.R. Treatment strategies for pelvic pain associated with adenomyosis. Gynecol. Endocrinol., 2016, 32(sup2), 19-22. [http://dx.doi.org/10.1080/09513590.2016.1232673] [PMID: 27759444] [http://dx.doi.org/10.1080/09513590.2016.1232673] [PMID: 27759444] [19] Taran, F.; Stewart, E.; Brucker, S. Adenomyosis: Epidemiology, risk factors, clinical phenotype and surgical and interventional alternatives to hysterectomy. Geburtshilfe Frauenheilkd., 2013, 73(9), 924-931. [http://dx.doi.org/10.1055/s-0033-1350840] [PMID: 24771944] [http://dx.doi.org/10.1055/s-0033-1350840] [PMID: 24771944] [20] Ravina, J.H.; Ciraru-Vigneron, N.; Bouret, J.M.; Herbreteau, D.; Houdart, E.; Aymard, A.; Merland, J.J. Arterial embolisation to treat uterine myomata. Lancet, 1995, 346(8976), 671-672. [http://dx.doi.org/10.1016/S0140-6736(95)92282-2] [PMID: 7544859] [http://dx.doi.org/10.1016/S0140-6736(95)92282-2] [PMID: 7544859] [21] de Bruijn, AM; Ankum, WM; Reekers, JA Uterine artery embolization vs. hysterectomy in the treatment of symptomatic uterine fibroids: 10-year outcomes from the randomized EMMY trial. Am. J. Obstet. Gyneco., 2016, 1215, e741-e745. [22] Edwards, R.D.; Moss, J.G.; Lumsden, M.A.; Wu, O.; Murray, L.S.; Twaddle, S.; Murray, G.D. Uterine-artery embolization versus surgery for symptomatic uterine fibroids. N. Engl. J. Med., 2007, 356(4), 360-370. [http://dx.doi.org/10.1056/NEJMoa062003] [PMID: 17251532] [http://dx.doi.org/10.1056/NEJMoa062003] [PMID: 17251532] [23] Popovic, M; Puchner, S; Berzaczy, D; Lammer, J; Bucek, RA Uterine artery embolization for the treatment of adenomyosis: A review. J. Vasc. Interv. Radiol., 2011, 22, 901-909. [http://dx.doi.org/10.1016/j.jvir.2011.03.013] [http://dx.doi.org/10.1016/j.jvir.2011.03.013] [24] de Bruijn, A.M.; Smink, M.; Hehenkamp, W.J.K.; Nijenhuis, R.J.; Smeets, A.J.; Boekkooi, F.; Reuwer, P.J.H.M.; Van Rooij, W.J.; Lohle, P.N.M. Uterine artery embolization for symptomatic adenomyosis: 7-year clinical follow-up using UFS-Qol questionnaire. Cardiovasc. Intervent. Radiol., 2017, 40(9), 1344-1350. [http://dx.doi.org/10.1007/s00270-017-1686-1] [PMID: 28516272] [http://dx.doi.org/10.1007/s00270-017-1686-1] [PMID: 28516272] [25] Alabiso, G.; Alio, L.; Arena, S.; Barbasetti di Prun, A.; Bergamini, V.; Berlanda, N.; Busacca, M.; Candiani, M.; Centini, G.; Di Cello, A.; Exacoustos, C.; Fedele, L.; Fuggetta, E.; Gabbi, L.; Geraci, E.; Imperiale, L.; Lavarini, E.; Incandela, D.; Lazzeri, L.; Luisi, S.; Maiorana, A.; Maneschi, F.; Mannini, L.; Mattei, A.; Muzii, L.; Pagliardini, L.; Perandini, A.; Perelli, F.; Pinzauti, S.; Porpora, M.G.; Remorgida, V.; Leone Roberti Maggiore, U.; Seracchioli, R.; Solima, E.; Somigliana, E.; Tosti, C.; Venturella, R.; Vercellini, P.; Viganò, P.; Vignali, M.; Zannoni, L.; Zullo, F.; Zupi, E. Adenomyosis: What the patient needs. J. Minim. Invasive Gynecol., 2016, 23(4), 476-488. [http://dx.doi.org/10.1016/j.jmig.2015.12.017] [PMID: 26772777] [http://dx.doi.org/10.1016/j.jmig.2015.12.017] [PMID: 26772777] [26] Leyendecker, G.; Bilgicyildirim, A.; Inacker, M.; Stalf, T.; Huppert, P.; Mall, G.; Böttcher, B.; Wildt, L. Adenomyosis and endometriosis. Re-visiting their association and further insights into the mechanisms of auto-traumatisation. An MRI study. Arch. Gynecol. Obstet., 2015, 291(4), 917-932. [http://dx.doi.org/10.1007/s00404-014-3437-8] [PMID: 25241270] [http://dx.doi.org/10.1007/s00404-014-3437-8] [PMID: 25241270] [27] Struble, J.; Reid, S.; Bedaiwy, M.A. Adenomyosis: A clinical review of a challenging gynecologic condition. J. Minim. Invasive Gynecol., 2016, 23(2), 164-185. [http://dx.doi.org/10.1016/j.jmig.2015.09.018] [PMID: 26427702] [http://dx.doi.org/10.1016/j.jmig.2015.09.018] [PMID: 26427702] [28] Vavilis, D.; Agorastos, T.; Tzafetas, J.; Loufopoulos, A.; Vakiani, M.; Constantinidis, T.; Patsiaoura, K.; Bontis, J. Adenomyosis at hysterectomy: Prevalence and relationship to operative findings and reproductive and menstrual factors. Clin. Exp. Obstet. Gynecol., 1997, 24(1), 36-38. [PMID: 9107456] [PMID: 9107456] [29] Seidman, J.D.; Kjerulff, K.H. Pathologic findings from the Maryland Women’s Health Study: Practice patterns in the diagnosis of adenomyosis. Int. J. Gynecol. Pathol., 1996, 15(3), 217-221. [http://dx.doi.org/10.1097/00004347-199607000-00005] [PMID: 8811382] [http://dx.doi.org/10.1097/00004347-199607000-00005] [PMID: 8811382] [30] Parazzini, F.; Vercellini, P.; Panazza, S.; Chatenoud, L.; Oldani, S.; Crosignani, P.G. Risk factors for adenomyosis. Hum. Reprod., 1997, 12(6), 1275-1279. [http://dx.doi.org/10.1093/humrep/12.6.1275] [PMID: 9222017] [http://dx.doi.org/10.1093/humrep/12.6.1275] [PMID: 9222017] [31] Togashi, K.; Nishimura, K.; Itoh, K.; Fujisawa, I.; Noma, S.; Kanaoka, M.; Nakano, Y.; Itoh, H.; Ozasa, H.; Fujii, S. Adenomyosis: Diagnosis with MR imaging. Radiology, 1988, 166(1), 111-114. [http://dx.doi.org/10.1148/radiology.166.1.3336669] [PMID: 3336669] [http://dx.doi.org/10.1148/radiology.166.1.3336669] [PMID: 3336669] [32] Bazot, M.; Daraï, E. Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis. Fertil. Steril., 2018, 109(3), 389-397. [http://dx.doi.org/10.1016/j.fertnstert.2018.01.024] [PMID: 29566851] [http://dx.doi.org/10.1016/j.fertnstert.2018.01.024] [PMID: 29566851] [33] Sugino, N. Uterine fibroids and adenomyosis; Springer: Singapore, 2018. [http://dx.doi.org/10.1007/978-981-10-7167-6] [http://dx.doi.org/10.1007/978-981-10-7167-6] [34] Atri, M.; Reinhold, C.; Mehio, A.R.; Chapman, W.B.; Bret, P.M. Adenomyosis: US features with histologic correlation in an in-vitro study. Radiology, 2000, 215(3), 783-790. [http://dx.doi.org/10.1148/radiology.215.3.r00jn06783] [PMID: 10831700] [http://dx.doi.org/10.1148/radiology.215.3.r00jn06783] [PMID: 10831700] [35] Bazot, M.; Daraï, E.; Rouger, J.; Detchev, R.; Cortez, A.; Uzan, S. Limitations of transvaginal sonography for the diagnosis of adenomyosis, with histopathological correlation. Ultrasound Obstet. Gynecol., 2002, 20(6), 605-611. [http://dx.doi.org/10.1046/j.1469-0705.2002.00852.x] [PMID: 12493051] [http://dx.doi.org/10.1046/j.1469-0705.2002.00852.x] [PMID: 12493051] [36] Fedele, L.; Bianchi, S.; Dorta, M.; Arcaini, L.; Zanotti, F.; Cannelli, S. Transvaginal ultrasonography in the diagnosis of diffuse adenomyosis. Fertil. Steril., 1992, 58(1), 94-97. [http://dx.doi.org/10.1016/S0015-0282(16)55142-5] [PMID: 1624029] [http://dx.doi.org/10.1016/S0015-0282(16)55142-5] [PMID: 1624029] [37] Kepkep, K.; Tuncay, Y.A.; Göynümer, G.; Tutal, E. Transvaginal sonography in the diagnosis of adenomyosis: Which findings are most accurate? Ultrasound Obstet. Gynecol., 2007, 30(3), 341-345. [http://dx.doi.org/10.1002/uog.3985] [PMID: 17659649] [http://dx.doi.org/10.1002/uog.3985] [PMID: 17659649] [38] Lin, P.; Sun, Y-L.; Wang, C-B.; Lee, C-Y.; Wun, T-H.; Lin, Y.H.; Tseng, C.C.; Chen, C.H.; Tseng, C.J. Transvaginal sonographic criteria for the diagnosis of adenomyosis based on histopathologic correlation. Taiwan. J. Obstet. Gynecol., 2010, 49(1), 40-44. [http://dx.doi.org/10.1016/S1028-4559(10)60007-1] [PMID: 20466291] [http://dx.doi.org/10.1016/S1028-4559(10)60007-1] [PMID: 20466291] [39] Exacoustos, C; Brienza, L; Di Giovanni, A. Adenomyosis: Three dimensional sonographic findings of the junctional zone and correlation with histology. Ultrasound. Obstet. Gyneco., 2011, 37(1), 471-479. [http://dx.doi.org/10.1002/uog.8900] [http://dx.doi.org/10.1002/uog.8900] [40] Meredith, SM; Sanchez-Ramos, L; Kaunitz, AM Diagnostic accuracy of transvaginal sonography for the diagnosis of adenomyosis: Systematic review and metaanalysis. Am. J. Obstet. Gynecol., 2009, 201, 107e1-107e6. [http://dx.doi.org/10.1016/j.ajog.2009.03.021] [http://dx.doi.org/10.1016/j.ajog.2009.03.021] [41] Dartmouth, K. A systematic review with meta-analysis: The common sonographic characteristics of adenomyosis. Ultrasound, 2014, 22(3), 148-157. [http://dx.doi.org/10.1177/1742271X14528837] [PMID: 27433212] [http://dx.doi.org/10.1177/1742271X14528837] [PMID: 27433212] [42] Andres, M.P.; Borrelli, G.M.; Ribeiro, J.; Baracat, E.C.; Abrão, M.S.; Kho, R.M. Transvaginal ultrasound for the diagnosis of adenomyosis: Systematic review and meta-analysis. J. Minim. Invasive Gynecol., 2018, 25(2), 257-264. [http://dx.doi.org/10.1016/j.jmig.2017.08.653] [PMID: 28864044] [http://dx.doi.org/10.1016/j.jmig.2017.08.653] [PMID: 28864044] [43] Togashi, K.; Ozasa, H.; Konishi, I.; Itoh, H.; Nishimura, K.; Fujisawa, I.; Noma, S.; Sagoh, T.; Minami, S.; Yamashita, K. Enlarged uterus: Differentiation between adenomyosis and leiomyoma with MR imaging. Radiology, 1989, 171(2), 531-534. [http://dx.doi.org/10.1148/radiology.171.2.2704819] [PMID: 2704819] [http://dx.doi.org/10.1148/radiology.171.2.2704819] [PMID: 2704819] [44] Reinhold, C; McCarthy, S; Bret, PM Diffuse adenomyosis: Comparison of endovaginal US and MR imaging with histopathologic correlation. Radiology, 1996, 199151 [http://dx.doi.org/10.1148/radiology.199.1.8633139] [http://dx.doi.org/10.1148/radiology.199.1.8633139] [45] Oliveira, M.A.P.; Crispi, C.P., Jr; Brollo, L.C.; Crispi, C.P.; De Wilde, R.L. Surgery in adenomyosis. Arch. Gynecol. Obstet., 2018, 297(3), 581-589. [http://dx.doi.org/10.1007/s00404-017-4603-6] [PMID: 29197987] [http://dx.doi.org/10.1007/s00404-017-4603-6] [PMID: 29197987] [46] Vannuccini, S.; Luisi, S.; Tosti, C.; Sorbi, F.; Petraglia, F. Role of medical therapy in the management of uterine adenomyosis. Fertil. Steril., 2018, 109(3), 398-405. [http://dx.doi.org/10.1016/j.fertnstert.2018.01.013] [PMID: 29566852] [http://dx.doi.org/10.1016/j.fertnstert.2018.01.013] [PMID: 29566852] [47] Tan, J.; Moriarty, S.; Taskin, O.; Allaire, C.; Williams, C.; Yong, P.; Bedaiwy, M.A. Reproductive outcomes after fertility-sparing surgery for focal and diffuse adenomyosis: A systematic review. J. Minim. Invasive Gynecol., 2018, 25(4), 608-621. [http://dx.doi.org/10.1016/j.jmig.2017.12.020] [PMID: 29305234] [http://dx.doi.org/10.1016/j.jmig.2017.12.020] [PMID: 29305234] [48] Pontis, A.; D’Alterio, M.N.; Pirarba, S.; de Angelis, C.; Tinelli, R.; Angioni, S. Adenomyosis: A systematic review of medical treatment. Gynecol. Endocrinol., 2016, 32(9), 696-700. [http://dx.doi.org/10.1080/09513590.2016.1197200] [PMID: 27379972] [http://dx.doi.org/10.1080/09513590.2016.1197200] [PMID: 27379972] [49] Pinzauti, S.; Lazzeri, L.; Tosti, C.; Centini, G.; Orlandini, C.; Luisi, S.; Zupi, E.; Exacoustos, C.; Petraglia, F. Transvaginal sonographic features of diffuse adenomyosis in 18-30-year-old nulligravid women without endometriosis: Association with symptoms. Ultrasound Obstet. Gynecol., 2015, 46(6), 730-736. [http://dx.doi.org/10.1002/uog.14834] [PMID: 25728241] [http://dx.doi.org/10.1002/uog.14834] [PMID: 25728241] [50] Mochimaru, A.; Aoki, S.; Oba, M.S.; Kurasawa, K.; Takahashi, T.; Hirahara, F. Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement. J. Obstet. Gynaecol. Res., 2015, 41(4), 529-533. [http://dx.doi.org/10.1111/jog.12604] [PMID: 25363157] [http://dx.doi.org/10.1111/jog.12604] [PMID: 25363157] [51] Taran, F.A.; Weaver, A.L.; Coddington, C.C.; Stewart, E.A. Understanding adenomyosis: A case control study. Fertil. Steril., 2010, 94(4), 1223-1228. [http://dx.doi.org/10.1016/j.fertnstert.2009.06.049] [PMID: 19643403] [http://dx.doi.org/10.1016/j.fertnstert.2009.06.049] [PMID: 19643403] [52] Vannuccini, S.; Tosti, C.; Carmona, F.; Huang, S.J.; Chapron, C.; Guo, S.W.; Petraglia, F. Pathogenesis of adenomyosis: An update on molecular mechanisms. Reprod. Biomed. Online, 2017, 35(5), 592-601. [http://dx.doi.org/10.1016/j.rbmo.2017.06.016] [PMID: 28693952] [http://dx.doi.org/10.1016/j.rbmo.2017.06.016] [PMID: 28693952] [53] Fedele, L.; Bianchi, S.; Frontino, G. Hormonal treatments for adenomyosis. Best Pract. Res. Clin. Obstet. Gynaecol., 2008, 22(2), 333-339. [http://dx.doi.org/10.1016/j.bpobgyn.2007.07.006] [PMID: 17765017] [http://dx.doi.org/10.1016/j.bpobgyn.2007.07.006] [PMID: 17765017] [54] Badawy, A.M.; Elnashar, A.M.; Mosbah, A.A. Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: A randomized controlled trial. Acta Obstet. Gynecol. Scand., 2012, 91(4), 489-495. [http://dx.doi.org/10.1111/j.1600-0412.2012.01350.x] [PMID: 22229256] [http://dx.doi.org/10.1111/j.1600-0412.2012.01350.x] [PMID: 22229256] [55] Tosti, C.; Vannuccini, S.; Lazzeri, L.; Luisi, S.; Petraglia, F.; Troìa, L. Current and future medical treatment of adenomyosis. J. Endometr., 2016, 8, 127-135. [56] Osada, H. Uterine adenomyosis and adenomyoma: The surgical approach. Fertil. Steril., 2018, 109(3), 406-417. [http://dx.doi.org/10.1016/j.fertnstert.2018.01.032] [PMID: 29566853] [http://dx.doi.org/10.1016/j.fertnstert.2018.01.032] [PMID: 29566853] [57] Fujishita, A.; Masuzaki, H.; Khan, K.N.; Kitajima, M.; Ishimaru, T. Modified reduction surgery for adenomyosis. A preliminary report of the transverse H incision technique. Gynecol. Obstet. Invest., 2004, 57(3), 132-138. [http://dx.doi.org/10.1159/000075830] [PMID: 14707472] [http://dx.doi.org/10.1159/000075830] [PMID: 14707472] [58] Saremi, A; Bahrami, H; Salehian, P; Hakak, N; Pooladi, A; Bahrami, H Treatment of adenomyomectomy in women with severe uterine adenomyosis using a novel technique. Reprod BioMed., 2014, 28, 753-760. [http://dx.doi.org/10.1016/j.rbmo.2014.02.008] [http://dx.doi.org/10.1016/j.rbmo.2014.02.008] [59] Huang, X.; Huang, Q.; Chen, S.; Zhang, J.; Lin, K.; Zhang, X. Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis. BMC Womens Health, 2015, 15(1), 24. [http://dx.doi.org/10.1186/s12905-015-0182-5] [PMID: 25783654] [http://dx.doi.org/10.1186/s12905-015-0182-5] [PMID: 25783654] [60] Kim, TH; Lee, HH; Chung, SH; Lee, W The triple-flap method for huge uterine adenomyosis with pelvic adhesions. Reprod BioMed., 2012, 25, 649-650. [http://dx.doi.org/10.1016/j.rbmo.2012.09.011] [http://dx.doi.org/10.1016/j.rbmo.2012.09.011] [61] Nishida, M.; Takano, K.; Arai, Y.; Ozone, H.; Ichikawa, R. Conservative surgical management for diffuse uterine adenomyosis. Fertil. Steril., 2010, 94(2), 715-719. [http://dx.doi.org/10.1016/j.fertnstert.2009.03.046] [PMID: 19406396] [http://dx.doi.org/10.1016/j.fertnstert.2009.03.046] [PMID: 19406396] [62] Takeuchi, H.; Kitade, M.; Kikuchi, I.; Shimanuki, H.; Kumakiri, J.; Kitano, T.; Kinoshita, K. Laparoscopic adenomyomectomy and hysteroplasty: A novel method. J. Minim. Invasive Gynecol., 2006, 13(2), 150-154. [http://dx.doi.org/10.1016/j.jmig.2005.12.004] [PMID: 16527719] [http://dx.doi.org/10.1016/j.jmig.2005.12.004] [PMID: 16527719] [63] Suginami, H.; Tokushige, M.; Taniguchi, F. Surgical treatment of adenomyosis. Obstet Gynecol, 2008, 75, 72-78. [64] Kishi, Y.; Yabuta, M.; Taniguchi, F. Who will benefit from uterus-sparing surgery in adenomyosis-associated subfertility? Fertil. Steril., 2014, 102(3), 802-807.e1. [http://dx.doi.org/10.1016/j.fertnstert.2014.05.028] [PMID: 24954774] [http://dx.doi.org/10.1016/j.fertnstert.2014.05.028] [PMID: 24954774] [65] Wang, P.H.; Fuh, J.L.; Chao, H.T.; Liu, W.M.; Cheng, M.H.; Chao, K.C. Is the surgical approach beneficial to subfertile women with symptomatic extensive adenomyosis? J. Obstet. Gynaecol. Res., 2009, 35(3), 495-502. [http://dx.doi.org/10.1111/j.1447-0756.2008.00951.x] [PMID: 19527389] [http://dx.doi.org/10.1111/j.1447-0756.2008.00951.x] [PMID: 19527389] [66] Grimbizis, GF; Mikos, T; Tarlatzis, B Uterus-sparing operative treatment for adenomyosis. Fertil. Steril., 2014, 101, 472-487. [http://dx.doi.org/10.1016/j.fertnstert.2013.10.025] [http://dx.doi.org/10.1016/j.fertnstert.2013.10.025] [67] Younes, G.; Tulandi, T. Conservative surgery for adenomyosis and results: A systematic review. J. Minim. Invasive Gynecol., 2018, 25(2), 265-276. [http://dx.doi.org/10.1016/j.jmig.2017.07.014] [PMID: 28739414] [http://dx.doi.org/10.1016/j.jmig.2017.07.014] [PMID: 28739414] [68] Cheung, V.Y.T. Current status of high-intensity focused ultrasound for the management of uterine adenomyosis. Ultrasonography, 2017, 36(2), 95-102. [http://dx.doi.org/10.14366/usg.16040] [PMID: 28145109] [http://dx.doi.org/10.14366/usg.16040] [PMID: 28145109] [69] Fukunishi, H.; Funaki, K.; Sawada, K.; Yamaguchi, K.; Maeda, T.; Kaji, Y. Early results of magnetic resonance-guided focused ultrasound surgery of adenomyosis: Analysis of 20 cases. J. Minim. Invasive Gynecol., 2008, 15(5), 571-579. [http://dx.doi.org/10.1016/j.jmig.2008.06.010] [PMID: 18657480] [http://dx.doi.org/10.1016/j.jmig.2008.06.010] [PMID: 18657480] [70] Jingqi, W.; Lu, Z.; Jun, Z.; Yuhong, M.; Wei, Y.; Lifeng, R.; Chengbing, J.; Dobromir, D.D.; Hui, Z.; Kun, Z. Clinical usefulness of the microbubble contrast agent SonoVue in enhancing the effects of high-intensity focused ultrasound for the treatment of adenomyosis. J. Ultrasound Med., 2018, 37(12), 2811-2819. [http://dx.doi.org/10.1002/jum.14638] [PMID: 29689636] [http://dx.doi.org/10.1002/jum.14638] [PMID: 29689636] [71] Xiao-Ying, Z.; Ying-Shu, G.; Jiu-Mei, C. Effect of pre-treatment with gonadotropin-releasing hormone analogue GnRH-α on high-intensity focussed ultrasound ablation for diffuse adenomyosis: A preliminary study. Int. J. Hyperthermia., 2018, 34(8), 1-9. [http://dx.doi.org/10.1080/02656736.2018.1440014] [http://dx.doi.org/10.1080/02656736.2018.1440014] [72] Hou, Y.; Qin, Z.; Fan, K.; Xu, Y.; Huang, X. Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis. Exp. Ther. Med., 2017, 15(2), 2104-2108. [http://dx.doi.org/10.3892/etm.2017.5601] [PMID: 29434812] [http://dx.doi.org/10.3892/etm.2017.5601] [PMID: 29434812] [73] Kim, MD; Kim, YM; Kim, HC Uterine artery embolization for symptomatic adenomyosis: A new technical development of the 1-2-3 protocol and predictive factors of MR imaging affecting outcomes. J. Vasc. Interv. Radiol., 2011, 22, 497-502. [http://dx.doi.org/10.1016/j.jvir.2011.01.426] [http://dx.doi.org/10.1016/j.jvir.2011.01.426] [74] Dueholm, M. Minimally invasive treatment of adenomyosis. Best Pract. Res. Clin. Obstet. Gynaecol., 2018, 51, 119-137. [http://dx.doi.org/10.1016/j.bpobgyn.2018.01.016] [PMID: 29555380] [http://dx.doi.org/10.1016/j.bpobgyn.2018.01.016] [PMID: 29555380] [75] de Bruijn, A.M.; Lohle, P.N.M.; Huirne, J.A.F.; de Vries, J.; Twisk, M.; Hehenkamp, W.J.K. Uterine artery embolization versus hysterectomy in the treatment of symptomatic adenomyosis: Protocol for the randomized questa trial. JMIR Res. Protoc., 2018, 7(3), e47. [http://dx.doi.org/10.2196/resprot.8512] [PMID: 29496654] [http://dx.doi.org/10.2196/resprot.8512] [PMID: 29496654] [76] Resnick, N.J.; Kim, E.; Patel, R.S.; Lookstein, R.A.; Nowakowski, F.S.; Fischman, A.M. Uterine artery embolization using a transradial approach: Initial experience and technique. J. Vasc. Interv. Radiol., 2014, 25(3), 443-447. [http://dx.doi.org/10.1016/j.jvir.2013.11.010] [PMID: 24581468] [http://dx.doi.org/10.1016/j.jvir.2013.11.010] [PMID: 24581468] [77] Bilhim, T.; Pisco, J.M.; Duarte, M.; Oliveira, A.G. Polyvinyl alcohol particle size for uterine artery embolization: A prospective randomized study of initial use of 350-500 μm particles versus initial use of 500-700 μm particles. J. Vasc. Interv. Radiol., 2011, 22(1), 21-27. [http://dx.doi.org/10.1016/j.jvir.2010.09.018] [PMID: 21106390] [http://dx.doi.org/10.1016/j.jvir.2010.09.018] [PMID: 21106390] [78] Firouznia, K.; Ghanaati, H.; Sanaati, M.; Jalali, A.H.; Shakiba, M. Pregnancy after uterine artery embolization for symptomatic fibroids: A series of 15 pregnancies. AJR Am. J. Roentgenol., 2009, 192(6), 1588-1592. [http://dx.doi.org/10.2214/AJR.07.3904] [PMID: 19457822] [http://dx.doi.org/10.2214/AJR.07.3904] [PMID: 19457822] [79] Das, C.J.; Rathinam, D.; Manchanda, S.; Srivastava, D.N. Endovascular uterine artery interventions. Indian J. Radiol. Imaging, 2017, 27(4), 488-495. [http://dx.doi.org/10.4103/ijri.IJRI_204_16] [PMID: 29379246] [http://dx.doi.org/10.4103/ijri.IJRI_204_16] [PMID: 29379246] 24 2

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