Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis

Yanmei Hou, Hou Y, Qin Z, Zhenli Qin, Fan K, Kefeng Fan, Xu Y, Yanhua Xu, Xiaoge Huang, X Huang, Huang X
Experimental and therapeutic medicine · 2017 · vol. 15(2) , pp. 2104–2108 · doi:10.3892/etm.2017.5601 · PMID:29434812 · PMC5776654 · W2773305494
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⚙ AI-generated summary by claude@2026-06, 2026-06-22 ⓘ

Combined high intensity focused ultrasound (HIFU) and metformin treatment significantly reduced menstrual flow and pain with lower inflammatory cytokine levels compared to single HIFU treatment in adenomyosis patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-22 · read from full text ⓘ

This study evaluated combined therapy with high intensity focused ultrasound (HIFU) plus metformin versus single HIFU in 274 patients with adenomyosis admitted to Jinan Maternity and Child Care Hospital. The authors report that both menstrual flow and pain were significantly reduced in the combined-treatment group compared with single HIFU (P<0.01), and that inflammatory cytokine levels decreased relative to baseline (P<0.01). The main limitation explicitly implied by the presentation is the lack of detailed methods or controls in the provided text, including how cytokines were measured and the extent of baseline comparability. This paper is centrally about endometriosis and/or adenomyosis — specifically adenomyosis — assessing whether adding metformin to HIFU improves symptom and inflammatory cytokine outcomes.

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Abstract

Adenomyosis is a pathological gynaecological condition characterized by benign invasion of the endometrium into the myometrium. High intensity focused ultrasound (HIFU) is one of the most common therapeutic strategies for the treatment of adenomyosis. However, the efficacy of single HIFU therapy is insufficient for the treatment of patients with adenomyosis. In the present study, the efficacy of HIFU and metformin for the treatment of adenomyosis was analyzed in 274 patients with adenomyosis who were admitted to Jinan Maternity and Child Care Hospital. The results demonstrated that there was a significant reduction in menstrual flow and pain between patients who received HIFU and metformin, and those who received single HIFU treatment (P<0.01). Furthermore, the outcomes demonstrated that inflammatory cytokines levels were significantly lower compared with the baseline values (P<0.01). In conclusion, the outcomes of the current study indicate that combined HIFU and metformin treatment is more efficacious in patients with enlarged adenomyosis compared with single HIFU treatment.
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Print ISSN: 1792-0981 Online ISSN: 1792-1015 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 2104-2108|Published online on: December 6, 2017https://doi.org/10.3892/etm.2017.5601 - Expand metrics + Adenomyosis is a pathological gynaecological condition characterized by benign invasion of the endometrium into the myometrium. High intensity focused ultrasound (HIFU) is one of the most common therapeutic strategies for the treatment of adenomyosis. However, the efficacy of single HIFU therapy is insufficient for the treatment of patients with adenomyosis. In the present study, the efficacy of HIFU and metformin for the treatment of adenomyosis was analyzed in 274 patients with adenomyosis who were admitted to Jinan Maternity and Child Care Hospital. The results demonstrated that there was a significant reduction in menstrual flow and pain between patients who received HIFU and metformin, and those who received single HIFU treatment (P<0.01). Furthermore, the outcomes demonstrated that inflammatory cytokines levels were significantly lower compared with the baseline values (P<0.01). In conclusion, the outcomes of the current study indicate that combined HIFU and metformin treatment is more efficacious in patients with enlarged adenomyosis compared with single HIFU treatment. Copy and paste a formatted citation Spandidos Publications style Hou Y, Qin Z, Fan K, Xu Y and Huang X: Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis. Exp Ther Med 15: 2104-2108, 2018. APA Hou, Y., Qin, Z., Fan, K., Xu, Y., & Huang, X. (2018). Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis. Experimental and Therapeutic Medicine, 15, 2104-2108. https://doi.org/10.3892/etm.2017.5601 MLA Hou, Y., Qin, Z., Fan, K., Xu, Y., Huang, X."Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis". Experimental and Therapeutic Medicine 15.2 (2018): 2104-2108. Chicago Hou, Y., Qin, Z., Fan, K., Xu, Y., Huang, X."Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis". Experimental and Therapeutic Medicine 15, no. 2 (2018): 2104-2108. https://doi.org/10.3892/etm.2017.5601

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