Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis
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⤵ 13 in-corpus citations
Abstract
Adenomyosis is a pathological gynaecological condition characterized by benign invasion of the endometrium into the myometrium. High intensity focused ultrasound (HIFU) is one of the most common therapeutic strategies for the treatment of adenomyosis. However, the efficacy of single HIFU therapy is insufficient for the treatment of patients with adenomyosis. In the present study, the efficacy of HIFU and metformin for the treatment of adenomyosis was analyzed in 274 patients with adenomyosis who were admitted to Jinan Maternity and Child Care Hospital. The results demonstrated that there was a significant reduction in menstrual flow and pain between patients who received HIFU and metformin, and those who received single HIFU treatment (P<0.01). Furthermore, the outcomes demonstrated that inflammatory cytokines levels were significantly lower compared with the baseline values (P<0.01). In conclusion, the outcomes of the current study indicate that combined HIFU and metformin treatment is more efficacious in patients with enlarged adenomyosis compared with single HIFU treatment.
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Cited by (13)
- Female Sexual Dysfunction After High-Intensity Focused Ultrasound versus Laparoscopic Total Hysterectomy for Adenomyosis: Associations with Anxiety and Depression 2026
- Analysis of HIFU Therapy for Adenomyosis: A Systematic Review 2025
- Experimental Models of Adenomyosis as the Basis for Developing New Methods in the Treatment of the Disease. Part II. Evaluation of the Effectiveness of Adenomyosis Treatment in Female Wistar Rats 2025
- Current Trends and Future Strategies on Diagnosis and Management of Adenomyosis: An Updated Review 2024
- Adenomyosis: Current knowledge, Recent Advances and Future Perspective 2023
- Hemoperitoneum caused by bleeding of adenomyosis: a case report 2021
- Surgical strategies in uterine adenomyosis 2021
- Adjuvant Therapy of HIFU Ablation for Adenomyosis 2021
- Management of uterine adenomyosis: current trends and uterine artery embolization as a potential alternative to hysterectomy 2019
- High-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone analogs (GnRHa) and levonorgestrel-releasing intrauterine system (LNG-IUS) for adenomyosis: a case series with long-term follow up 2019
- Endometriosis treatment with shock waves: A novel approach 2019
- Influences of screening magnetic resonance imaging parameters on high-intensity focused ultrasound outcome for adenomyosis 2018
- Current status of high-intensity focused ultrasound for the management of uterine adenomyosis 2016
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- europepmc
- last seen: 2026-06-14T06:08:20.186862+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:20:01.354358+00:00
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