Feasibility of MRI-guided high intensity focused ultrasound treatment for adenomyosis

Tien-Ying Fan, Fan TY, Zhang L, Lian Zhang, Chen W, Wenzhi Chen, Liu Y, Yinjiang Liu, Min He, He M, Xiu Huang, Huang X, Orsi F, Franco Orsi, Wang Z, Zhibiao Wang
European journal of radiology · 2011 · vol. 81(11) , pp. 3624–3630 · doi:10.1016/j.ejrad.2011.05.036 · PMID:21719223 · W2132017576
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This study investigates the feasibility of using MRI-guided high-intensity focused ultrasound as a treatment for adenomyosis.

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Abstract

PurposeTo test the feasibility of MRI-guided high intensity focused ultrasound ablation for adenomyosis.Materials and methodsPatients with symptomatic adenomyosis were treated with MRI-guided high intensity focused ultrasound (MRIgHIFU). Under conscious sedation, MRIgHIFU was performed by a clinical MRI-compatible focused ultrasound tumour therapeutic system (JM15100, Haifu® Technology Co. Ltd., Chongqing, China) which is combined with a 1.5 T MRI system (Magnetom Symphony, Siemens Healthcare, Erlangen, Germany). MRI was used to calculate the volume of the uterus and lesion. Non-perfused volume of the targeted lesions was evaluated immediately after MRIgHIFU. Patient symptoms were assessed using symptom severity score (SSS) and uterine fibroids symptoms and quality of life questionnaire (UFS-QOL).ResultsTen patients with mean age of 40.3±4 years with an average lesion size of 56.9±12.7 mm in diameter were treated. Non-perfused volume and the percentage of non-perfused volume obtained from contrast-enhanced T1 Magnetic resonance images immediately post-treatment were 66.6±49.4 cm3 and 62.5±21.6%, respectively. The mean SSS and UFS-QOL showed significant improvements of 25%, 16% and 25% at 3, 6 and 12 months follow up, respectively, to pre-treatment scores. No serious complications were observed.ConclusionBased on the results from this study, MRIgHIFU treatment appears to be a safe and feasible modality to ablate adenomyosis lesion and alleviate its symptoms.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis High-Intensity Focused Ultrasound Ablation Magnetic Resonance Imaging Surgery, Computer-Assisted Adenomyosis Adult Feasibility Studies Female High-Intensity Focused Ultrasound Ablation Humans Magnetic Resonance Imaging Reproducibility of Results Sensitivity and Specificity Surgery, Computer-Assisted Treatment Outcome

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