Clinical Usefulness of the Microbubble Contrast Agent SonoVue in Enhancing the Effects of High‐Intensity Focused Ultrasound for the Treatment of Adenomyosis

Wang Jingqi, Jingqi Wang, Lu Zhang, Zhang Lu, Lu Z, Jun Zhang, Jun Z, Zhang Jun, Yuhong M, Ma Yuhong, Yuhong Ma, Wei Yang, Wei Y, Yang Wei, Lifeng R, Lifeng Ran, Ran Lifeng, Chengbing J, Chengbing Jin, Jin Chengbing, Dimitrov Dimitrov Dobromir, Dobromir Dimitrov, Dobromir DD, Zhu Hui, Hui Zhu, Hui Z, Kun Z, Zhou Kun, Kun Zhou
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2018 · vol. 37(12) , pp. 2811–2819 · doi:10.1002/jum.14638 · PMID:29689636 · W2801158476
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⚙ AI-generated summary by claude@2026-06, 2026-06-27 ⓘ

Starting high-intensity focused ultrasound 1 minute after SonoVue injection enhanced ablation in adenomyosis patients by reducing sonication time, total energy, and mean power while remaining safe.

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Abstract

OBJECTIVE: To evaluate the clinical usefulness of the microbubble contrast agent SonoVue in enhancing high-intensity focused ultrasound (HIFU) for the treatment of adenomyosis. METHODS: A total of 102 patients with adenomyosis, assessed from August 2015 to April 2017, were randomly divided into 1-minute (A) and 10-minute (B) groups, respectively. In groups A and B, HIFU started 1 minute and 10 minutes, respectively, after SonoVue injection. All patients underwent a magnetic resonance imaging scan before and after HIFU treatment. RESULTS: The occurrence rates of massive gray scale change, nonperfused volume, and fractional ablation were similar in both groups (P > .05). Meanwhile, sonication time to massive gray scale change was reduced in group A compared with group B (P < .05). In addition, mean power, total energy, and energy efficiency factor were lower in group A than group B (all P .05). The incidence rates of pain in the treated region, leg pain, and sciatic or buttock pain during HIFU were substantially lower in group A than group B (P < .05). CONCLUSIONS: Overall, starting HIFU sonication at 1 minute after SonoVue injection enhances HIFU ablation by cavitation and heating and is safe. Early massive gray scale change, lower total energy, and reduced mean power are potential safety factors.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Contrast Media Extracorporeal Shockwave Therapy Image Enhancement Phospholipids Sulfur Hexafluoride Adenomyosis Adult Extracorporeal Shockwave Therapy Female Humans Image Enhancement Microbubbles Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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