Clinical Usefulness of the Microbubble Contrast Agent SonoVue in Enhancing the Effects of High‐Intensity Focused Ultrasound for the Treatment of Adenomyosis

Jingqi Wang, Wang Jingqi, Zhang Lu, Lu Zhang, Jun Zhang, Zhang Jun, Yuhong Ma, Ma Yuhong, Yang Wei, Wei Yang, Lifeng Ran, Ran Lifeng, Chengbing Jin, Jin Chengbing, Dobromir Dimitrov, Dimitrov Dimitrov Dobromir, Hui Zhu, Zhu Hui, Kun Zhou, Zhou Kun
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2018 · vol. 37(12) , pp. 2811–2819 · doi:10.1002/jum.14638 · PMID:29689636 · W2801158476
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Abstract

OBJECTIVE: To evaluate the clinical usefulness of the microbubble contrast agent SonoVue in enhancing high-intensity focused ultrasound (HIFU) for the treatment of adenomyosis. METHODS: A total of 102 patients with adenomyosis, assessed from August 2015 to April 2017, were randomly divided into 1-minute (A) and 10-minute (B) groups, respectively. In groups A and B, HIFU started 1 minute and 10 minutes, respectively, after SonoVue injection. All patients underwent a magnetic resonance imaging scan before and after HIFU treatment. RESULTS: The occurrence rates of massive gray scale change, nonperfused volume, and fractional ablation were similar in both groups (P > .05). Meanwhile, sonication time to massive gray scale change was reduced in group A compared with group B (P < .05). In addition, mean power, total energy, and energy efficiency factor were lower in group A than group B (all P .05). The incidence rates of pain in the treated region, leg pain, and sciatic or buttock pain during HIFU were substantially lower in group A than group B (P < .05). CONCLUSIONS: Overall, starting HIFU sonication at 1 minute after SonoVue injection enhances HIFU ablation by cavitation and heating and is safe. Early massive gray scale change, lower total energy, and reduced mean power are potential safety factors.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Contrast Media Extracorporeal Shockwave Therapy Image Enhancement Phospholipids Sulfur Hexafluoride Adenomyosis Adult Extracorporeal Shockwave Therapy Female Humans Image Enhancement Microbubbles Treatment Outcome

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