RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis

Caixia Jiang, Wei Gong, Rong Chen, Huihui Ke, Xiaoyan Qu, Weihong Yang, Zhongping Cheng
The Journal of international medical research · 2018 · vol. 46(12) , pp. 5019–5029 · doi:10.1177/0300060518789038 · PMID:30387365 · W2899395241
article OA: gold CC0 ⤵ 7 in-corpus citations
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RhoA/ROCK pathway proteins were upregulated and ARHGAP26 was downregulated in adenomyosis endometrium, correlating with clinical characteristics like menorrhagia.

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Abstract

OBJECTIVE: This study aimed to investigate RhoA, RhoA-associated coiled-coil containing protein kinase (ROCK) 1, ROCK2, and Rho GTPase-activating protein 26 (ARHGAP26) expression in the eutopic endometrium (EU) and ectopic endometrium (EC), and examine their relationships with the clinical characteristics of adenomyosis. METHODS: Twenty patients with adenomyosis who underwent laparoscopy were recruited. Protein and mRNA expression of RhoA, ROCK1, ROCK2, and ARHGAP26 in EU and EC of patients with adenomyosis and in control endometrium without adenomyosis (CE) was detected. RESULTS: ROCK1, ROCK2, and RhoA mRNA expression in EU was significantly higher than that in CE, and was highest in EC. ARHGAP26 mRNA expression in EC and EU was significantly lower than that in CE. ROCK1, ROCK2, and RhoA protein expression in EC and EU was significantly higher than that in CE. ARHGAP26 protein expression in EC and EU was significantly lower than that in CE. ROCK1, ROCK2, and RhoA gene and protein expression was positively associated and ARHGAP26 was negatively associated with the severity of menorrhagia and menstrual capacity in adenomyosis. CONCLUSIONS: RhoA, ROCK1, and ROCK2 expression is upregulated, and ARHGAP26 expression is downregulated in adenomyosis. The RhoA/ROCK-mediated signaling pathway is associated with dysmenorrhea and menstrual capacity in adenomyosis.

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Condition tags

adenomyosisdysmenorrhea

MeSH descriptors

Adenomyosis Biomarkers Endometrium GTPase-Activating Proteins rhoA GTP-Binding Protein rho-Associated Kinases Adenomyosis Adenomyosis Adenomyosis Adult Biomarkers Case-Control Studies Endometrium Endometrium Female Follow-Up Studies GTPase-Activating Proteins GTPase-Activating Proteins Humans Middle Aged

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Cited by (7)

SciLite annotations

chemicals 12
estrogen guanosine 5'-monophosphate guanosine 5'-monophosphate guanosine 5'-monophosphate progestin levonorgestrel nitrogen sodium sulfate polyacrylamide macromolecule nitrocellulose estrogen
organisms 8
human naine d'afrique de l'ouest rabbits somali wild ass naine d'afrique de l'ouest transgenic mice noordeloos 2009062 rodents

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