Modern possibilities for the diagnosis of adenomyosis

Maria A. Shalina, Maria I. Yarmolinskaya, Elena I. Abashova
In: Journal of obstetrics and women's diseases · 2020 · vol. 69(1) , pp. 73–80 · doi:10.17816/jowd69173-80 · W3017385029
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses the pathogenesis, classifications, and genetic/immunological factors of adenomyosis, highlighting the most informative non-invasive diagnostic markers from current research.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This review synthesizes modern evidence on the diagnosis and pathogenesis of adenomyosis, emphasizing proposed classifications and the role of genetic and immunological factors in internal endometriosis, alongside comparisons of non-invasive diagnostic markers. It highlights that clinical presentation varies and that diagnosis is complicated by overlap with conditions like uterine myoma and endometrial hyperplasia, while ultrasound accuracy for adenomyosis is reported to range widely (20–86%) and MRI is described as highly informative (up to 95% sensitivity/specificity) but limited by cost and availability; the paper also notes the absence of a single specific clinical picture as a caveat. Key imaging discussion centers on the MRI “transition zone” (junctional zone), with proposed thickness criteria (e.g., ≥12 mm) and grade-based MRI findings, while immunologic findings in peripheral blood are summarized as showing altered B-, T-, and natural killer cell activity. Relevance to endometriosis: the paper discusses adenomyosis in the context of internal endometriosis and explicitly addresses shared pathological mechanisms with external genital endometriosis, though its main focus is a diagnostic overview for adenomyosis.

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Abstract

This review article presents modern data on the diagnosis and pathogenesis of adenomyosis, various classifications of the disease being highlighted. The role of genetic and immunological factors in the development of internal endometriosis is discussed. The results of domestic and foreign studies are presented, with the most informative non-invasive markers for the diagnosis of adenomyosis described.

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endometriosisadenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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