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Abstract
Like endometriosis, uterine adenomyosis is another enigmatic disease and remains a source of controversy. Uterine adenomyosis is characterized by the presence of endometrial glands in the myometrium. Two main theories may explain its pathogenesis: adenomyosis may arise from invagination of the myometrial basalis into the myometrium; or an alternative theory maintains that it may result from metaplasia of displaced embryonic pluripotent müllerian remants or differentiation of adult stem cells. Uterine adenomyosis is responsible for pelvic pain, abnormal bleeding, and infertility. Its diagnosis may be improved by high quality imaging. This issue's Views and Reviews, authors stress the urgent need to establish some systematic classification. Medical and surgical strategies are discussed. It should be emphasized that treatment should be designed according to a patient's symptoms and an individual's needs. Surgical treatment remains a matter of debate. Indeed, the risk of uterine rupture during pregnancy after adenomyomectomy is a reality. Therefore, continued research into new molecules based on the pathogenic mechanisms is vital.
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References (5)
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Cited by (50)
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- Identification of Misplaced Endometrial Glands and Stroma in the Myometrium of Foetal Uteri Evocative of Developmental Adenomyosis 2026
- Impact of adenomyosis on fertility and obstetric outcomes among women in tertiary care center 2025
- Effect of Elagolix in comparison to Dienogest in the treatment of symptomatic adenomyosis 2025
- The present adenomyosis treatment status in Luzhou, China: a small scope observational cross-sectional survey 2025
- Risk factors for uterine adenomyosis diagnosed by MRI in women of reproductive age 2025
- Treatment-related changes in adenomyosis: a primer for radiologists 2025
- Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies 2024
- Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies 2024
- Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition 2024
- Knowledge, attitudes, and practices among Chinese reproductive-age women toward uterine adenomyosis 2024
- Pulmonary embolism after diagnostic curettage in patient with adenomyosis and hysteromyoma: A case report and brief review of literature 2023
- Modern approaches to classification of adenomyosis 2023
- Endometriosis and adenomyosis: Similarities and differences 2023
- M2 macrophages enhance endometrial cell invasiveness by promoting collective cell migration in uterine adenomyosis 2023
- Effect of Mifepristone vs Placebo for Treatment of Adenomyosis With Pain Symptoms: A Randomized Clinical Trial 2023
- Are lower levels of apoptosis and autophagy behind adenomyotic lesion survival? 2023
- ІНСТРУМЕНТИ ОЦІНКИ ХРОНІЧНОГО ТАЗОВОГО БОЛЮ У ЖІНОК 2023
- Study on differentially expressed genes and participating pathways of ectopic endometrium in adenomyosis patients with different data sets 2023
- Fertility and Obstetric Outcomes of Assisted Reproductive Technology (ART) in Women With Adenomyosis Following Gonadotropin-Releasing Hormone Agonist Therapy: A Single-Center Experience 2023
- Robot-assisted Laparoscopic Adenomyomectomy 2022
- Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies 2022
- Medical Treatment of Adenomyosis 2022
- Factors influencing treatment decisions in HIFU treatment of adenomyosis: A retrospective study 2022
- Adenomyosis and fertility: a modern view of the problem. A literature review 2022
- Secondary cystic adenomyosis in a young woman: a case report 2022
- The Advantages and Disadvantages of Uterine Artery Embolization in Women with Adenomyosis: What’s New? 2021
- Adenomyosis and Pain 2021
- Mifepristone Treats Symptomatic Adenomyosis: A Multicentre, Randomized, Double-Blind and Placebo-Controlled Trial 2021
- Modern possibilities for the diagnosis of adenomyosis 2021
- Efficient myometrial defect closure in a layer by layer fashion after robot-assisted laparoscopic adenomyomectomy: a novel technique 2021
- An integrated approach to the treatment of pelvic pain associated with adenomyosis 2021
- Minimally Invasive Surgical Treatment of Pelvic Pain in Teenagers and Young Women 2021
- Talin1 Induces Epithelial-Mesenchymal Transition to Facilitate Endometrial Cell Migration and Invasion in Adenomyosis Under the Regulation of microRNA-145-5p 2021
- Uterine Adenomyosis Treated by Linzagolix, an Oral Gonadotropin-Releasing Hormone Receptor Antagonist: A Pilot Study with a New ’Hit Hard First and then Maintain’ Regimen of Administration 2021
- Investigation of the role of platelets in the aetiopathogenesis of adenomyosis 2021
- Minimally invasive adenomyomectomy via a laparoscopic-assisted approach compared to a laparoscopic or laparotomic approach 2021
- GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions 2021
- Androgens, oestrogens and endometrium: a fine balance between perfection and pathology 2020
- Modern possibilities for the diagnosis of adenomyosis 2020
- Adenomyosis incidence, prevalence and treatment: United States population-based study 2006–2015 2020
- Adenomyosis: clinical aspects, impact on fertility and pregnancy outcome 2020
- Diagnosis of uterine adenomyosis in patients of reproductive age 2020
- Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis 2020
- A comparison of surgical outcomes between robot and laparoscopy-assisted adenomyomectomy 2019
- Adenomyosis and pregnant uterus: An alliance doomed to rupture? 2019
- Mechanisms Underlying Adenomyosis-Related Fibrogenesis 2019
- A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis 2019
- Expression of Cannabinoid Receptors in Myometrium and its Correlation With Dysmenorrhea in Adenomyosis 2019
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- last seen: 2026-07-25T06:15:30.875455+00:00
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- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
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