Adenomyosis and fertility: a modern view of the problem. A literature review

This literature review is based on resources from the following databases: CyberLeninka, PubMed, MedArt, and the Central Scientific Medical Library (I.M. Sechenov First Moscow State Medical University, Moscow, Russia). Adenomyosis is a common non-infectious uterine pathology associated with the risk of infertility and obstetric problems. The local inflammation that develops in adenomyosis reduces the probability of blastocyst implantation and creates an unfavorable environment for the development of the embryo. Adenomyosis reduces the effectiveness of assisted reproductive technology. During the pregnancy in adenomyosis, the risk of incomplete and prolonged pregnancy increases at almost all stages. Besides, the risk of massive hemorrhage increases during pregnancy, childbirth and the early postpartum period. The presented review helps to assess the pathogenetic mechanisms underlying the negative effect of adenomyosis on women’s fertility based on data obtained over the past ten years.

Full Text About the authors Vitaly F. Bezhenar Academician I.P. Pavlov First Saint Petersburg State Medical University Author for correspondence. Email: [email protected] ORCID iD: 0000-0002-7807-4929 SPIN-code: 8626-7555 ResearcherId: R-7055-2017 MD, Dr. Sci. (Med.), Professor Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022Viktor A. Linde Academician I.P. Pavlov First Saint Petersburg State Medical University Email: [email protected] ORCID iD: 0000-0002-6032-1936 Scopus Author ID: 56825712100 MD, Dr. Sci. (Med.), Professor Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022Byuzand V. Arakelyan Academician I.P. Pavlov First Saint Petersburg State Medical University Email: [email protected] ORCID iD: 0000-0002-2868-7997 MD, Dr. Sci. (Med.), Assistant Professor Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022Alla S. Kalugina Academician I.P. Pavlov First Saint Petersburg State Medical University Email: [email protected] ORCID iD: 0000-0002-4796-7812 ResearcherId: B-6355-2016 MD, Dr. Sci. (Med.), Professor Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022Yuri V. Vasilyev Saint Petersburg State Pediatric Medical University Email: [email protected] ORCID iD: 0000-0001-5102-1774 MD, Cand. Sci. (Med.), Assistant Professor Russian Federation, Saint PetersburgDarya A. Sobakina City Alexandrovskaya Hospital Email: [email protected] ORCID iD: 0000-0002-4610-4126 MD Russian Federation, Saint PetersburgElmina E. Sadykhova Academician I.P. Pavlov First Saint Petersburg State Medical University Email: [email protected] ORCID iD: 0000-0003-1157-7801 MD Russian Federation, 6-8, L’va Tolstogo St., Saint Petersburg, 197022Viktoria A. 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