Activation of the MAPK/ERK Cell-Signaling Pathway in Uterine Smooth Muscle Cells of Women With Adenomyosis

Isabelle Streuli, Pietro Santulli, Piétro Santulli, Sandrine Chouzenoux, Charles Chapron, Frédéric Batteux
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 22(12) , pp. 1549–1560 · doi:10.1177/1933719115589410 · PMID:26071388 · W1153782677
article OA: closed CC0 ⤵ 21 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Uterine smooth muscle cells from women with adenomyosis show increased proliferation and MAPK/ERK pathway activation, independent of ROS, suggesting these pathways' implication in proliferation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper investigated whether uterine smooth muscle cells (uSMCs) from women with adenomyosis show intrinsic differences in activation of MAPK/ERK and PI3K/mTOR/AKT signaling pathways, and whether reactive oxygen species (ROS) production is involved. uSMCs were cultured from myometrium biopsies collected during hysterectomy or myomectomy from women with adenomyosis and controls with leiomyoma, and the authors assessed pathway activation, uSMC proliferation, and ROS production/detoxification. They found increased uSMC proliferation and increased in vitro MAPK/ERK activation in adenomyosis versus controls, while PI3K/mTOR/AKT activation was not significantly different and ROS-related pathways were similar between groups, supporting ROS-independent MAPK/ERK activation. A caveat is that signaling and proliferation were measured in vitro in uSMC cultures derived from limited clinical samples. This paper is centrally about endometriosis and/or adenomyosis — it specifically demonstrates MAPK/ERK pathway activation in uterine smooth muscle cells of women with adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Cell Proliferation Cell Proliferation Extracellular Signal-Regulated MAP Kinases Myocytes, Smooth Muscle Myometrium Signal Transduction Signal Transduction Adenomyosis Adenomyosis Adult Antioxidants Antioxidants Case-Control Studies Cells, Cultured Enzyme Activation Extracellular Signal-Regulated MAP Kinases Extracellular Signal-Regulated MAP Kinases Female Humans

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