What the Endometrium Says About Adenomyosis

Maria Rosa Maduro
In: Reproductive Sciences · 2016 · vol. 23(10) , pp. 1281 · doi:10.1177/1933719116658402 · W3048947358
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-10 ⓘ

This review discusses the association between adenomyosis and subfertility, citing evidence for both correlation and causation between these conditions.

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This paper is a short narrative piece describing and synthesizing what transcriptomic and immunologic changes in the eutopic endometrium have revealed about adenomyosis. It highlights reported “global transcriptome abnormalities” and cytokine profiling findings during implantation-relevant time windows, alongside mechanistic observations from studies in induced-adenomyosis mouse models and uterine smooth muscle cell signaling. A key limitation is that it is not a new primary experiment, and its conclusions depend on the breadth and interpretability of prior heterogeneous studies. This paper is centrally about adenomyosis — it focuses on interpreting how findings from the endometrium (particularly eutopic endometrial changes) relate to adenomyosis pathophysiology.

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Article PDF References Tomassetti, C, Meuleman, C, Timmerman, D, D’Hooghe, T Adeno-myosis and subfertility: evidence of association and causation. Semin Reprod Med. 2013;31(02):101–108. Mao, X, Wang, Y, Carter, AV, Zhen, X, Guo, SW The retardation of myometrial infiltration, reduction of uterine contractility, and alle-viation of generalized hyperalgesia in mice with induced adeno-myosis by levo-tetrahydropalmatine (l-THP) and andrographolide. Reprod Sci. 2011;18(10):1025–1037. Zhihong, N, Yun, F, Pinggui, Z, Sulian, Z, Zhang, A Cytokine profil-ing in the eutopic endometrium of adenomyosis during the implan-tation window after ovarian stimulation. Reprod Sci. 2016;23(1): 124–133. Chen, Y, Zhu, B, Zhang, H, Ding, D, Liu, X, Guo, SW Possible loss of GABAergic inhibition in mice with induced adenomyosis and treatment with epigallocatechin-3-gallate attenuates the loss with improved hyperalgesia. Reprod Sci. 2014;21(7):869–882. Zhu, B, Chen, Y, Zhang, H, Liu, X, Guo, SW Resveratrol reduces myometrial infiltration, uterine hyperactivity, and stress levels and alleviates generalized hyperalgesia in mice with induced adeno-myosis. Reprod Sci. 2015;22(11):1336–1349. Lazzeri, L, Di Giovanni, A, Exacoustos, C, et al. Preoperative and postoperative clinical and transvaginal ultrasound findings of ade-nomyosis in patients with deep infiltrating endometriosis. Reprod Sci. 2014;21(8):1027–1033. Streuli, I, Santulli, P, Chouzenoux, S, Chapron, C, Batteux, F Activation of the MAPK/ERK cell-signaling pathway in uterine smooth muscle cells of women with adenomyosis. Reprod Sci. 2015; 22(12):1549–1560. Herndon, CN, Aghajanova, L, Bayalan, S, et al. Global transcriptome abnormalities of the eutopic endometrium from women with ade-nomyosis. Reprod Sci. 2016;23(10):1289–1303. Rights and permissions About this article Cite this article Maduro, M.R. What the Endometrium Says About Adenomyosis. Reprod. Sci. 23, 1281 (2016). https://doi.org/10.1177/1933719116658402 Published: Issue date: DOI: https://doi.org/10.1177/1933719116658402

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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