Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window
Observational
OA: closed
CC0
⤵ 26 in-corpus citations
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This study investigated the expression of integrin β3 and osteopontin in the eutopic endometrium of women with adenomyosis during the implantation window.
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Abstract
OBJECTIVE: To investigate the expression of integrin β3 and osteopontin (OPN) in the eutopic endometrium of adenomyosis and to characterize possible endometrial defects in adenomyosis.
STUDY DESIGN: Twenty-eight adenomyosis patients and 27 control fertile women were involved in this study. Endometrial samples were collected during the implantation window. Integrin β3 subunits and OPN in the adenomyosis and control endometria were assessed by immunohistochemical staining and quantitative real-time polymerase chain reaction. A one-tailed t-test and a non-parametric Mann-Whitney U-test were used to test significance.
RESULTS: The mRNA and immunostaining intensity of integrin β3 and OPN were significantly lower in the adenomyosis patients than in the controls.
CONCLUSIONS: Abnormal expression of integrin β3 and OPN in the endometrium of adenomyosis may contribute to infertility in some patients.
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Cited by (26)
- Fertility outcome following ovarian stimulation in infertile women having pretreatment with levonorgestrel releasing intrauterine system versus dienogest for symptomatic adenomyosis 2025
- The administration of long in-vitro fertilization protocol in adenomyosis: case series 2024
- Receptivity of the endometrium in infertility associated with adenomyosis 2023
- Adenomyosis: In-Vitro Fertilization Does Not Improve Pregnancy Outcome as Compared to Conventional Infertility Treatment 2023
- Pregnancy outcomes in women with adenomyosis, undergoing artificial endometrial preparation with and without gonadotropin-releasing hormone agonist pretreatment in frozen embryo transfer cycles: An RCT 2023
- Biomechanical Forces Determine Fibroid Stem Cell Transformation and the Receptivity Status of the Endometrium: A Critical Appraisal 2022
- How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights 2022
- Endometrial receptivity in adenomyosis and the role of signaling pathways in the pathogenesis of the disease (literature review) 2022
- Osteopontin Splicing Isoforms Contribute to Endometriotic Proliferation, Migration, and Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells 2022
- Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis 2022
- Comparison of oocyte count, fertilization, and pregnancy rates in adenomyosis patients undergoing In Vitro Fertilization with short and long protocol controlled ovarian stimulation - Restospective study 2022
- The Pathogenesis of Adenomyosis 2021
- Adenomyosis and Infertility-Review of Medical and Surgical Approaches 2021
- Menstrual fluid endometrial stem/progenitor cell and supernatant protein content: cyclical variation and indicative range 2021
- Endometriosis and Infertility: Surgery and IVF: When, Why, and Outcomes 2020
- Adenomyosis: Mechanisms and Pathogenesis 2020
- Determining the Molecular Background of Endometrial Receptivity in Adenomyosis 2020
- Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity 2019
- Bioinformatics strategy for the screening of key genes to differentiate adenomyosis from endometriosis (Review) 2019
- Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis 2018
- Pathogenesis of adenomyosis: an update on molecular mechanisms 2017
- Serum Osteopontin Levels Are Decreased in Focal Adenomyosis 2016
- Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment 2016
- Pathogenetic aspects of endometriosis-associated infertility 2015
- Activation of the MAPK/ERK Cell-Signaling Pathway in Uterine Smooth Muscle Cells of Women With Adenomyosis 2015
- Adenomyosis 2014
Source provenance
- europepmc
- last seen: 2026-10-11T09:27:45.537177+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:12:29.265612+00:00
- unpaywall
- last seen: 2026-10-11T06:28:45.473802+00:00
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