Tenascin is differentially expressed in endometrium and endometriosis

Deborah J. Harrington, D J Harrington, Harrington DJ, B A Lessey, Lessey BA, Bruce A. Lessey, Vikram Rai, V Rai, Rai V, A Bergqvist, Agneta Bergqvist, Bergqvist A, S Kennedy, Stephen Kennedy, Kennedy S, Sanjiv Manek, Manek S, S Manek, Barlow DH, D H Barlow, David H. Barlow, Helen J. Mardon, H J Mardon, Mardon HJ
The Journal of Pathology · 1999 · vol. 187(2) , pp. 242–248 · doi:10.1002/(sici)1096-9896(199901)187:2<242::aid-path221>3.0.co;2-t · PMID:10365101 · W2053353431
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Tenascin expression is elevated in both proliferative endometrium and endometriosis, while collagen IV, laminin, vitronectin, and fibronectin show similar patterns in both tissues.

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Abstract

Endometriosis is characterized by the presence of functional endometrial tissue outside the uterine cavity, most commonly on the ovary and peritoneum. The aetiology of endometriosis is not understood, although the adhesion of endometrial cells to the extracellular matrix (ECM) would be expected to play a central role in its pathogenesis. The expression of ECM molecules in endometrium and in endometriosis has been investigated using immunohistochemistry and western blotting techniques. The ECM components collagen IV, laminin, vitronectin, and fibronectin had a similar pattern of expression throughout the menstrual cycle in endometrium and endometriosis. Expression of tenascin was elevated in the stroma of the functionalis region of the endometrium during the proliferative stage of the menstrual cycle and in endometriosis. Tenascin expression in endometriosis was not modulated according to the stage of the menstrual cycle. It is concluded that expression of tenascin is strictly regulated in endometrium and may be important in endometrial regeneration and in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Tenascin Adult Blotting, Western Cell Division Cell Division Collagen Collagen Endometriosis Endometriosis Endometrium Female Fibronectins Fibronectins Humans Immunoenzyme Techniques Laminin Laminin Menstrual Cycle

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