Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis

Petra Klemmt, Anna Starzinski‐Powitz
In: Endometriosis · 2011 · pp. 115–129 · doi:10.1002/9781444398519.ch11 · W1580098801
other OA: closed CC0 ⤵ 4 in-corpus citations
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This review examines the cell biology of eutopic and ectopic endometrium in endometriosis, focusing on differentiation, escape mechanisms, and microenvironment influences, particularly cell adhesion molecules and their modulation by pelvic fluid factors.

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Abstract

The pathogenesis and etiology of endometriosis are difficult to dissect experimentally and remain a challenging problem both clinically and scientifically. The basis of improved understanding is better knowledge of its cell biology. Therefore, we address in this review the cell biology of eutopic and ectopic endometrium in the context of cell differentiation, escape mechanisms and the influence of the pelvic microenvironment on the development of endometriotic lesions. We revisit experimental and descriptive observations regarding the presumed changes in eutopic endometrial phenotype in affected women and the emergence and differential expression of molecules in endometriotic foci. Here we focus on the molecular mechanisms of cell–cell adhesion, particularly the role of cadherin expression and the integrin/extracellular matrix expression profile and their putative modulation by growth factors, prostaglandins and interleukins increased in the pelvic fluid of affected women.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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