Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells

Banu SK, Sakhila K Banu, JeHoon Lee, Starzinski-Powitz A, Anna Starzinski‐Powitz, Anna Starzinski-Powitz, Arosh JA, Joe A Arosh
Fertility and sterility · 2007 · vol. 90(4) , pp. 972–987 · doi:10.1016/j.fertnstert.2007.07.1358 · PMID:18001719 · W2094997595
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This study characterized the gene expression profiles and functional properties of human immortalized endometriotic epithelial and stromal cells.

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Abstract

ObjectiveTo determine whether immortalized endometriotic cells can be used as potential models to unravel pathophysiology/pathogenesis of endometriosis in humans.DesignIn vitro study. Human immortalized endometriotic epithelial and stromal cells.SettingCollege of Veterinary Medicine and Biomedical Sciences, Texas A&M University.Patient(s)Not applicable.Intervention(s)None.Main outcome measure(s)Gene expression pattern and prostaglandin E(2) production and activity of matrix metalloproteinase 2 and matrix metalloproteinase 9.Result(s)Several genes associated with estrogen and progesterone biosynthesis and signaling, cell cycle regulation, extracellular matrix degradation, angiogenesis, cell growth and survival, cytokine production, and prostaglandin E(2) biosynthesis, transport, and signaling were expressed in human immortalized endometriotic cells. These endometriotic epithelial and stromal cells exhibited migrating and invading potential, produced a high quantity of prostaglandin E(2), and showed higher matrix metalloproteinase 2 and matrix metalloproteinase 9 activity compared to normal endometrial, epithelial, and stromal cells.Conclusion(s)Human immortalized endometriotic epithelial and stromal cells could be used as ideal models to study the molecular and cellular aspects of endometriosis in humans.

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MeSH descriptors

Cytokines Endometrium Epithelial Cells Estrogens Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Progesterone Cell Cycle Proteins Cell Cycle Proteins Cell Line Cytokines Endometrium Endometrium Epithelial Cells Epithelial Cells Estrogens Female Gene Expression Profiling Humans Matrix Metalloproteinase 2

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