Pyrvinium pamoate inhibits proliferation and invasion of human endometriotic stromal cells

Amin Karamian, Hamid Nazarian, H Nazarian, Seyed Ali Ziai, S A Ziai, Ziai SA, A.H. Zarnani, A-H Zarnani, Zarnani AH, Shadab Salehpour, Salehpour S, S Salehpour, Paktinat S, Shahrokh Paktinat, S Paktinat, MG Novin, M G Novin, Novin MG
Human & experimental toxicology · 2019 · vol. 39(5) , pp. 662–672 · doi:10.1177/0960327119896612 · PMID:31880170 · W2997142898
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Pyrvinium pamoate treatment in vitro significantly reduced the proliferation and invasiveness of human endometriotic and control endometrial stromal cells.

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Abstract

Endometriosis is characterized by the presence of functional endometrial tissue in other pelvic organs. This gynecologic problem occurs in 35-50% of women with pain and infertility. Endometriotic cells share some characteristics such as proliferation, migration, and invasion with tumor cells. Pyrvinium pamoate, an anthelmintic drug approved by the Food and Drug Administration, could inhibit the Wnt/β-catenin signaling pathway and its anticancer effects were examined by several researchers. In this study, 12 ectopic and eutopic endometrial biopsies from females with ovarian endometrioma and 12 endometrial biopsies from nonendometriotic females were obtained. Ectopic (EESCs), eutopic (EuESCs), and control (CESCs) endometrial stromal cells were isolated. Then, the effect of pyrvinium pamoate on the proliferation and invasiveness of in vitro cultured cells was evaluated. The proliferation of CESCs, EuESCs, and EESCs was significantly decreased after treatment with pyrvinium pamoate. In addition, treatment with pyrvinium pamoate significantly inhibited the invasiveness of CESCs, EuESCs, and EESCs compared to nontreated groups. The results of the present research showed that pyrvinium pamoate inhibits the proliferation and invasion of human endometriotic stromal cells in vitro, further investigations on the therapeutic potential of this compound in endometriosis are required.

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Cell Proliferation Endometrium Pyrvinium Compounds Stromal Cells Adult Cell Movement Cell Movement Cell Proliferation Cells, Cultured Cyclin D1 Cyclin D1 Endometriosis Endometrium Female Humans Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Pyrvinium Compounds Stromal Cells

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