Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells

Amin Karamian, Shahrokh Paktinat, Sahar Esfandyari, Hamid Nazarian, Seyed Ali Ziai, Amir‐Hassan Zarnani, Amir-Hassan Zarnani, Saghar Salehpour, Shadab Salehpour, Hossein Hosseinirad, Armin Karamian, Marefat Ghaffari Novin
Human & experimental toxicology · 2020 · vol. 40(4) , pp. 649–660 · doi:10.1177/0960327120964543 · PMID:33021119 · W3090829756
article OA: closed CC0 ⤵ 15 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

Endometriosis, a chronic inflammatory disease, is identified by the presence of endometrial tissue outside the uterus. The prevalence of this disease among reproductive-age women is almost 10-15%. High levels of IL-6 and IL-8 have been found in the peritoneal fluid (PF) of women with endometriosis and are involved in its pathogenesis. Isolated stromal cells from 12 ectopic and eutopic endometrial biopsies of women with ovarian endometrioma and also 12 endometrial biopsies of nonendometriotic controls were treated with 1.1 µM pyrvinium pamoate, a Wnt/β-catenin signaling pathway inhibitor, for 72 hrs. Before treatment, mRNA gene expression and secretion of IL-6 and IL-8 were significantly higher in ectopic (EESCs) than eutopic (EuESCs) and control (CESCs) endometrial stromal cells. After treatment, mRNA gene expression and also secretion of IL-6 and IL-8 were significantly reduced. Our Findings showed that pyrvinium pamoate suppresses the mRNA gene expression and secretion of IL-6 and IL-8 in human endometriotic stromal cells. Additional investigations on this compound are required before clinical application.

My notes (saved in your browser only)

Condition tags

endometriosisendometrioma

MeSH descriptors

Anthelmintics Interleukin-6 Interleukin-8 Pyrvinium Compounds Stromal Cells Adult Anthelmintics Cells, Cultured Cell Survival Cell Survival Endometrium Endometrium Female Humans Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 Pyrvinium Compounds RNA, Messenger

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (64)

Cited by (15)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:21:42.008780+00:00
License: CC0 · commercial use OK