The Search for Biomarkers in Endometriosis: a Long and Windy Road

Milena Králíčková, Václav Větvička, Luděk Fiala, Antonio Simone Laganà, Simone Garzon
Reproductive sciences (Thousand Oaks, Calif.) · 2021 · vol. 29(6) , pp. 1667–1673 · doi:10.1007/s43032-021-00668-2 · PMID:34159571 · W3173713711
review OA: closed CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This review summarizes significant and novel biomarker results for the diagnosis and follow-up of women with endometriosis, aiming to aid early diagnosis and management.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This review describes research on biomarkers for non-invasive diagnosis and follow-up of women with endometriosis, emphasizing the need for reliable, cost-effective markers that could reduce reliance on laparoscopy and histological confirmation. It discusses the debated pathogenesis of this estrogen-dependent disease and surveys “most significant and novel results” across candidate biomarker classes, including molecular and serologic approaches. A major limitation explicitly acknowledged is that, despite adequate accuracy of some non-invasive methods, laparoscopy is still often required for definitive diagnosis, and the underlying disease mechanisms remain unclear. This paper is centrally about endometriosis — it reviews biomarkers aimed at non-invasive diagnosis and follow-up in endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Biomarkers Female Humans

Citation neighborhood

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References (76)

Cited by (14)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:31.988741+00:00
License: CC0 · commercial use OK