Increased expression of stemness genes Rex-1, Oct-4, Nanog, and Sox-2 in women with ovarian endometriosis versus normal endometrium: A case-control study

Fatameh Shariati, Raha Favaedi, Fariba Ramazanali, Pegah Ghoraeian, Parvaneh Afsharian, Behrouz Aflatoonian, Reza Aflatoonian, Maryam Shahhoseini
International journal of reproductive biomedicine · 2019 · vol. 16(12) , pp. 783–790 · doi:10.18502/ijrm.v16i12.3684 · PMID:31417979 · W2920678153
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found significantly increased OCT-4, NANOG, and SOX-2 mRNA expression in ectopic endometriosis lesions compared to eutopic and normal endometrium.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This case-control study compared gene expression in women with ovarian endometriosis versus normal endometrium, focusing on the stemness-associated genes Rex-1, Oct-4, Nanog, and Sox-2. The authors reported increased expression of these stemness genes in ovarian endometriosis samples relative to normal endometrium. A key limitation is that the summary provided here does not specify sample size, tissue source/collection details, or statistical methods, which constrains evaluation of effect magnitude and potential confounding. This paper is centrally about endometriosis—specifically, stemness gene overexpression in ovarian endometriosis compared with normal endometrium.

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Abstract

Background: Endometriosis is a common, chronic inflammatory disease which is defined as an overgrowth of endometrial tissue outside the uterine cavity. The etiology of this disease is complex and multifactorial but there is a strong evidence that supports the presence of endometrial stem cells and their possible involvement in endometriosis. Objective: In this study, we analyzed the mRNA expression of REX-1 stemness gene and reconsidered three other stemness genes SOX-2, NANOG, OCT-4 in women with endometriosis compared to normal endometrium. Materials and Methods: Ten ectopic and ten eutopic tissue samples along with 23 normal endometrium specimens were recruited in this study. The expression levels of OCT-4, NANOG, SOX-2, and REX-1 genes were evaluated by the quantitative real-time polymerase chain reaction. Results: The transcription levels of OCT-4, NANOG, and SOX-2 mRNA were significantly increased in ectopic lesions compared with eutopic and control group (p = 0.041, p = 0.035, p = 0.048), although the REX-1 mRNA increase was not significant between endometriosis and control groups. Also, there were differences in the expression level of these genes in normal endometrium during the menstrual cycles (p = 0.031, p = 0.047, p = 0.031). Conclusion: Based on our data, we confirm the dynamic role of stemness genes in proliferation and growth of normal endometrium during the menstrual cycle and conclude that differential expression n levels of these genes may contribute to the pathophysiology of endometriosis. Key words: Endometriosis, Stemness genes.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 27 January 2019 Authors Fatameh Shariati | Raha Favaedi | Fariba Ramazanali | Pegah Ghoraeian | Parvaneh Afsharian | Behrouz Aflatoonian | Reza Aflatoonian | Maryam Shahhoseini The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v16i12.3684', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/3684', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://journals.ssu.ac.ir/ijrmnew/article-1-1334-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/3684/7660', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '27 January 2019', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Increased expression of stemness genes Rex-1, Oct-4, Nanog, and Sox-2 in women with ovarian endometriosis versus normal endometrium: A case-control study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v16i12.3684', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Fatameh Shariati | Raha Favaedi | Fariba Ramazanali | Pegah Ghoraeian | Parvaneh Afsharian | Behrouz Aflatoonian | Reza Aflatoonian | Maryam Shahhoseini', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v16i12.3684 JSON XML

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