International journal of reproductive biomedicine

The DNA damage response (DDR) is a fundamental cellular network that preserves genomic integrity, and its dysregulation drives initiation, progression, and therapeutic response in female reproductive system and breast cancers. This narrativ…

The application of artificial intelligence (AI) is expanding in all fields of medicine, including infertility treatment. This article examines the different uses of AI in reproductive healthcare. This article focuses on predictive models, i…

BACKGROUND: Epigenetic mechanisms, particularly the roles of DNA methylation and microRNAs, are increasingly recognized in the pathogenesis of endometriosis. DNA methyltransferase 3 (DNMT3) alpha, an important DNA methyltransferase, and miR…

BackgroundIndividuals with spinal cord injury (SCI) face fertility concerns due to various causes, such as low sperm quality and ejaculatory dysfunction. Consequently, different sperm retrieval techniques are used for these cases, including…

BACKGROUND: Endometriosis has potential negative effects on the fertility, mental, and sexual health of women. Since the conducted studies have not comprehensively addressed the needs and strategies to improve sexual health, and to design t…

BACKGROUND: Endometriosis is a chronic inflammatory disorder affecting about 10% of females in their reproductive years, characterized by endometrial tissue growing outside the uterus. Immune checkpoints play a crucial role in regulating th…

BackgroundAssessing depression, anxiety, and stress levels in women with infertility, along with their coping strategies, can significantly improve their mental health.ObjectiveThis study examined the relationship between coping mechanisms …

BackgroundRecurrent implantation failure remains a challenge in assisted reproduction. Intralipid has been proposed as an immunomodulatory intervention to improve outcomes, although evidence remains inconsistent.ObjectiveThis study aimed to…

BackgroundEndometrial-derived hydrogels are rich in extracellular matrix proteins as well as bioactive molecules that promote cell adhesion, proliferation, and angiogenesis.ObjectiveThis study investigates the potential of recellularized hu…

BackgroundThis case report presents the treatment of a gestational trophoblastic neoplasia pregnancy after in vitro fertilization (IVF). The incidence of moles in pregnancies resulting from IVF is rare, although studies show that the risk o…

BACKGROUND: Endometriosis, a common gynecological disorder involving ectopic endometrial tissue, leads to infertility and chronic pain. Dysregulated apoptosis and abnormal cell migration are key pathological features. Given current treatmen…

BACKGROUND: Endometriosis affects about 10% of reproductive-age women, causing pelvic pain and infertility. Its progression involves angiogenesis and neurovascular innervation, mediated by vascular endothelial growth factor (VEGF) and brain…

BackgroundDiminished ovarian reserve (DOR) is a major cause of female infertility, marked by reduced oocyte quantity and quality. STAG3 and DMC1 are meiosis-specific genes essential for chromosomal integrity and homologous recombination. Wh…

BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder and a major cause of anovulatory infertility. Serum anti-Müllerian hormone (AMH), a marker of ovarian reserve, is often elevated in PCOS. However, its predictive valu…

BackgroundPoor ovarian response remains one of the most challenging problems in assisted reproductive technology. Various stimulation protocols have been proposed to improve outcomes, including combined gonadotropin-releasing hormone (GnRH)…

Endometriosis is a complex chronic condition, driven by estrogen, characterized by the growth of endometrial-like tissue outside the uterus. This often-debilitating disease affects millions of women globally, manifesting as severe pelvic pa…

More than 40% of infertility causes are attributed to women. Polyendocrine metabolic ovarian syndrome (PMOS) is one of the important and common causes of infertility in women. Recurrent miscarriage is defined as the occurrence of 2 or 3 con…

Background: Endometriosis is one of the most common gynecological conditions, and the gold standard for its diagnosis is laparoscopy. Cytokeratin fragment 21-1 (CYFRA 21-1) has emerged as a potential biomarker candidate due to its strong as…

BackgroundThe number of follicles aspirated during intracytoplasmic sperm injection (ICSI)/in vitro fertilization (IVF) treatment does not always match the number of oocytes recovered.ObjectiveThis study aimed to assess the oocyte retrieval…

BackgroundFrozen-thawed embryo transfer (FET) during the endometrial receptivity window is important for implantation.ObjectiveThis study aims to compare the clinical pregnancy rate in 2 methods of endometrial preparation in FET using the h…

BackgroundRecurrent implantation failure poses a significant challenge in assisted reproductive technology despite the transfer of high-quality embryos over multiple cycles.ObjectiveThis study aimed to compare the clinical outcomes between …

BackgroundPolycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility. In women undergoing frozen embryo transfer, the method of endometrial preparation (hormone replacement therapy [HRT] or mild ovarian stimulation [MOS]…

BackgroundIn women with poor ovarian response (POR), the quantity and quality of oocytes produced by the ovaries decrease, resulting in poor-quality embryos. Ovarian stimulation, by increasing the number of oocytes and embryos, improves in …