Artificial intelligence in infertility treatment: Applications, challenges, and future directions: A narrative review.

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This narrative review examines artificial intelligence applications in infertility treatment, highlighting improvements in embryo selection and personalized therapeutic strategies while addressing ethical challenges and data limitations.

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This narrative review synthesizes 126 studies to evaluate the applications, challenges, and future directions of artificial intelligence in infertility treatment. The authors highlight how machine learning enhances diagnostic precision in male semen analysis and improves embryo selection accuracy during IVF cycles by reducing subjective human error. A significant caveat noted is that many AI models suffer from limited generalizability due to reliance on single-center datasets and a lack of independent external validation for live birth outcomes. Relevance to endometriosis: listed as one indication for female infertility components, with the paper noting that deep learning models can detect deep infiltrating endometriosis via MRI with higher sensitivity than radiologists.

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Abstract

The application of artificial intelligence (AI) is expanding in all fields of medicine, including infertility treatment. This article examines the different uses of AI in reproductive healthcare. This article focuses on predictive models, imaging processing, and personalized therapeutic strategies. AI-based software is increasingly being deployed for diagnosis and patient prognosis, utilizing big data derived from patient information and clinical outcomes. Thus, the prediction reliability of embryo implantation in in-vitro fertilization procedures notably increases. Furthermore, AI is revolutionizing embryo selection and sperm quality assessment through computer-based image processing systems and intracytoplasmic morphologically selected sperm injection techniques, thereby improving accuracy and consistency compared to traditional embryologist-dependent methods that heavily rely on the embryologists' skills. The paper reflects AI as the main factor in the formation of patient-specific treatment plans, risk reduction, and increased clinical success rates. Notwithstanding the immense potential, the implementation of AI in infertility treatment faces tangible issues, among which issues around ethics, privacy, quality, and diversity of data are prominent. This paper reviews current studies on the state-of-the-art possible and real failures of AI-focused strategies, as well as future research directions in the treatment of infertility.
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Section

AI is increasingly embedded across the infertility care pathway from semen analysis and female factor diagnostics to embryo selection and individualized treatment planning. Evidence suggests that, when supported by diverse multimodal data and rigorous validation, AI can improve discrimination and consistency over conventional methods. However, durable gains in patient-centered outcomes (live birth, time-to-pregnancy, ovarian hyperstimulation syndrome reduction, and cost-effectiveness) require multi-center prospective trials, transparent reporting, fairness audits, and robust clinical integration. In the near term, AI should be positioned as clinician-supervised decision support rather than a standalone selector or prescriber.

Coi Statement

The author declares that there is no conflict of interest.

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License: CC-BY-NC-4.0