The role of gene polymorphisms in infertility, polyendocrine metabolic ovarian syndrome and recurrent miscarriage in the Iranian women population: A review study

More than 40% of infertility causes are attributed to women. Polyendocrine metabolic ovarian syndrome (PMOS) is one of the important and common causes of infertility in women. Recurrent miscarriage is defined as the occurrence of 2 or 3 consecutive spontaneous miscarriages before the 20 th wk of pregnancy. The origin of recurrent miscarriage is unknown in 50% of cases, which are called idiopathic recurrent miscarriage. The present study aims to investigate the relationship between gene polymorphisms and infertility, PMOS, and recurrent miscarriage in Iranian women. This review study was conducted by examining reliable domestic and foreign sources between 2000 and 2026. For this purpose, 80 articles were selected and reviewed using the Scientific Information Database, Scopus, ScienceDirect, and PubMed databases, with an emphasis on the most relevant and newest sources. The results of the studies indicate the effective association of some of these gene polymorphisms with infertility, PMOS, and recurrent miscarriage in Iranian women. Some gene polymorphisms also showed no association with the aforementioned diseases. To better understand the association of these polymorphisms with infertility and recurrent miscarriage in women, there is a need for larger populations with more numbers and to study all environmental and climatic aspects of the populations. Investigating the role of different genes in the body's response to various drugs is of great importance in determining appropriate treatment methods and can also be important in population screening.