Adding fuel to the fire? Platelet-rich plasma-induced estrogen rise in endometriosis patients

Hossein Torkashvand, Shamim Pilehvari
In: International Journal of Reproductive BioMedicine (IJRM) · 2026 · vol. 24(9) · doi:10.18502/ijrm.v24i9.21871 · W7225106561
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⚙ AI-generated summary by qwen3.7-flash, 2026-11-05 ⓘ

This letter to the editor questions whether platelet-rich plasma treatment causes an estrogen rise that could exacerbate endometriosis.

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This letter to the editor raises concerns regarding the safety of platelet-rich plasma administration in patients with endometriosis. The authors highlight that platelet-rich plasma can induce a rise in estrogen levels, which may exacerbate the condition given its estrogen-dependent nature. They question whether this hormonal stimulation adds fuel to the inflammatory process associated with endometriosis lesions. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

This is a Letter to the Editor and does not have an abstract. Please download the PDF or view the article in HTML.
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Abstract

This is a Letter to the Editor and does not have an abstract. Please download the PDF or view the article in HTML.

References

[1] Vaidakis D, Papapanou M, Siristatidis CS. Autologous platelet-rich plasma for assisted reproduction. Cochrane Database Syst Rev 2024; 4: CD013875. [2] Serdarogullari M, Raad G, Makieva S, Liperis G, Fraire-Zamora JJ, Celik-Ozenci C. Revitalizing female fertility: Platelet-rich plasma-hype or hope? Reprod Biomed Online 2024; 49: 103813. [3] Li W, Xu J, Deng D. The effect of ovarian response parameters and the synergistic effect of assisted reproduction of poor ovarian response treated with platelet rich plasma: Systematic review and meta-analysis. BMC Womens Health 2024; 24: 263. [4] Safarova S, Cevher Akdulum MF, Guler I, Bozkurt N, Erdem A, Karabacak RO. Does platelet-rich plasma treatment increase in vitro fertilization (IVF) success in the infertile population? Cureus 2023; 15: e47239. [5] Navali N, Sadeghi L, Farzadi L, Ghasemzadeh A, Hamdi K, Hakimi P, et al. Intraovarian injection of autologous platelet-rich plasma improves therapeutic approaches in the patients with poor ovarian response: A before-after study. Int J Fertil Steril 2022; 16: 90–94. [6] Chantalat E, Valera M-C, Vaysse C, Noirrit E, Rusidze M, Weyl A, et al. Estrogen receptors and endometriosis. Int J Mol Sci 2020; 21: 2815. [7] Vannuccini S, Clemenza S, Rossi M, Petraglia F. Hormonal treatments for endometriosis: The endocrine background. Rev Endocr Metab Disord 2022; 23: 333–355. [8] Mariadas H, Jie-Hong Chen J-H, Chen K-H. The molecular and cellular mechanisms of endometriosis: From basic pathophysiology to clinical implications. Int J Mol Sci 2025; 26: 2458.

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last seen: 2026-11-07T06:05:52.158007+00:00
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