Expression and significance of CD133 and ABCG2 in endometriosis

S Liu, Liu S, J Zhou, Zhou J, Jian Zhou, J Wen, Wen J, Jianyan Wen
Clinical and experimental obstetrics & gynecology · 2015 · vol. 42(6) , pp. 771–775 · doi:10.12891/ceog1978.2015 · PMID:26753483 · W2280420859
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This study found that CD133 and ABCG2 protein expression were higher in eutopic and ectopic endometrial tissues of endometriosis patients compared to controls, with CD133 correlating with disease severity.

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The study examined stemness-related markers CD133 and ABCG2 in eutopic and ectopic endometrial tissues from patients with endometriosis, compared with endometrium from controls, using Western blot analysis. It found that eutopic endometrium had higher CD133 and ABCG2 protein levels than both ectopic endometrium and control endometrium, with statistically significant differences. CD133 expression in ectopic tissue was positively correlated with the R-AFS endometriosis score, while ABCG2 showed no significant association with R-AFS; among three patients with recurrence, two had higher ABCG2 expression than non-recurrence patients. This paper is centrally about endometriosis—specifically measuring CD133 and ABCG2 protein expression in eutopic and ectopic endometrial tissues to assess their relevance to endometriosis stem-cell–associated mechanisms.

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Abstract

BACKGROUND: Endometriosis is a common gynecological disease and exact pathogenesis is still unclear. Recently, an increasing interest has been given to the potential role of stem cells in the development of endometriosis. The aim of this study was to test the expression of sterness-related markers CD133 and ABCG2 in endometriosis. MATERIALS AND METHODS: CD133 and ABCG2 protein expression in eutopic and ectopic endometrial tissue with endometriosis and endometrium tissue without endometriosis were examined by Western blot. RESULTS: Eutopic endometrium showed high level of CD133 and ABCG2 protein when compared with ectopic endometrium (p = 0.042, p = 0.038) and control endometrium (p = 0.000, p = 0.000). The expression of CD133 protein in ectopic endometrium was positively correlated with R-AFS score of endometriosis (p = 0.000, r = 0.793) and no significant relation was noted between ABCG2 and R-AFS score (p = 0.563). Two of three patients with recurrence had much higher expression of ABCG2 protein than the patients without recurrence. CONCLUSION: Aberrant expression of CD133 and ABCG2 in eutopic and ectopic endometrial tissue with endometriosis suggests that they are probably associated with the pathogenesis of endometriosis and stem cells play a possible role in its development.
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Abstract

Background: Endometriosis is a common gynecological disease and exact pathogenesis is still unclear. Recently, an increasing interest has been given to the potential role of stem cells in the development of endometriosis. The aim of this study was to test the expression of stemness-related markers CD133 and ABCG2 in endometriosis. Materials and Methods: CD133 and ABCG2 protein expression in eutopic and ectopic endometrial tissue with endometriosis and endometrium tissue without endometriosis were examined by Western blot. Results: Eutopic endometrium showed high level of CD133 and ABCG2 protein when compared with ectopic endometrium (p = 0.042, p = 0.038) and control endometrium (p = 0.000, p = 0.000). The expression of CD133 protein in ectopic endometrium was positively correlated with R-AFS score of endometriosis (p = 0.000, r = 0.793) and no significant relation was noted between ABCG2 and R-AFS score (p = 0.563). Two of three patients with recurrence had much higher expression of ABCG2 protein than the patients without recurrence. Conclusion: Aberrant expression of CD133 and ABCG2 in eutopic and ectopic endometrial tissue with endometriosis suggests that they are probably associated with the pathogenesis of endometriosis and stem cells play a possible role in its development.

Keywords

- Endometriosis - Stem cells - CD133 - ABCG2

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Condition tags

endometriosis

MeSH descriptors

Antigens, CD ATP-Binding Cassette Transporters Endometriosis Endometrium Glycoproteins Neoplasm Proteins Peptides AC133 Antigen Adult Antigens, CD ATP-Binding Cassette Transporters ATP Binding Cassette Transporter, Subfamily G, Member 2 Case-Control Studies Endometriosis Endometriosis Endometrium Female Glycoproteins Humans Neoplasm Proteins

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