Expression and significance of CD133 and ABCG2 in endometriosis

S Liu, Jian Zhou, J Zhou, Jianyan Wen, J Wen
Clinical and experimental obstetrics & gynecology · 2015 · vol. 42(6) , pp. 771–775 · doi:10.12891/ceog1978.2015 · PMID:26753483 · W2280420859
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This study found that CD133 and ABCG2 protein expression were higher in eutopic and ectopic endometrial tissues of endometriosis patients compared to controls, with CD133 correlating with disease severity.

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Abstract

BACKGROUND: Endometriosis is a common gynecological disease and exact pathogenesis is still unclear. Recently, an increasing interest has been given to the potential role of stem cells in the development of endometriosis. The aim of this study was to test the expression of sterness-related markers CD133 and ABCG2 in endometriosis. MATERIALS AND METHODS: CD133 and ABCG2 protein expression in eutopic and ectopic endometrial tissue with endometriosis and endometrium tissue without endometriosis were examined by Western blot. RESULTS: Eutopic endometrium showed high level of CD133 and ABCG2 protein when compared with ectopic endometrium (p = 0.042, p = 0.038) and control endometrium (p = 0.000, p = 0.000). The expression of CD133 protein in ectopic endometrium was positively correlated with R-AFS score of endometriosis (p = 0.000, r = 0.793) and no significant relation was noted between ABCG2 and R-AFS score (p = 0.563). Two of three patients with recurrence had much higher expression of ABCG2 protein than the patients without recurrence. CONCLUSION: Aberrant expression of CD133 and ABCG2 in eutopic and ectopic endometrial tissue with endometriosis suggests that they are probably associated with the pathogenesis of endometriosis and stem cells play a possible role in its development.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Antigens, CD ATP-Binding Cassette Transporters Endometriosis Endometrium Glycoproteins Neoplasm Proteins Peptides AC133 Antigen Adult Antigens, CD ATP-Binding Cassette Transporters ATP Binding Cassette Transporter, Subfamily G, Member 2 Case-Control Studies Endometriosis Endometriosis Endometrium Female Glycoproteins Humans Neoplasm Proteins

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

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